Fibrous hamartoma of the tongue: report of a case with immunohistochemical and ultrastructural studies

Yoshihara, T.; Oda, Akiko; Takahashi, Yuko; Ishii, Tetsuo; Yaku, Yuji

doi:10.1016/0165-5876(95)01206-q

Cited by 6 publications

(5 citation statements)

References 19 publications

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“…Mesenchymal hamartomas, which are much less common than epithelial hamartomas, can be subdivided into chondroid, chondromesenchymal, angiomatous, lipomatous, and leiomyomatous hamartomas, depending on the preponderant tissue [7]. Although several leiomyomatous hamartomas have been observed in the oral cavity [9,10], none to date has been reported in the nasopharynx. To our knowledge, this may be the first report of a nasopharyngeal leiomyomatous hamartoma.…”

Section: Discussionmentioning

confidence: 99%

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Nasopharyngeal leiomyomatous hamartoma: case report

Nishiyama¹,

Kato

Baba

2014

BMC Ear Nose Throat Disord

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BackgroundFibroma, neurofibroma, and papilloma are the most commonly encountered benign lesions in the nasopharynx. Hamartomas are non-neoplastic overgrowth of mature/differentiated tissue indigenous to the specific part of the body in which they develop. Most hamartomas are located in the liver, spleen, lungs, and pancreas. However, nasopharyngeal hamartoma is rare.Case presentationWe describe here a 77-year-old Japanese woman who presented with a mass arising from the left lateral wall of the nasopharynx. Computed tomography (CT) revealed a soft tissue mass without bony erosion, suggesting that the mass was a benign tumor such as a fibroma. Pathological examination showed that the mass was a leiomyomatous hamartoma.ConclusionTo our knowledge, this is the first report of a leiomyomatous hamartoma in the nasopharynx. Although leiomyomatous hamartoma in the nasopharynx is extremely rare, it should be kept in mind during differential diagnosis.

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Section: Discussionmentioning

confidence: 99%

“…Leiomyomatous hamartomas in the oral cavity tend to occur in the midline of the maxillary gingiva and tongue [9,10]. This may have been due to an embryogenic error occurring during the fusion of the primary palate with the lateral palatine processes during the formation of the palate [11].…”

Section: Discussionmentioning

confidence: 99%

Nasopharyngeal leiomyomatous hamartoma: case report

Nishiyama¹,

Kato

Baba

2014

BMC Ear Nose Throat Disord

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“…It mostly occurs in the axilla, followed by the shoulder, upper arm, abdomen, chest wall, inguinal region, while the localization in the head and neck region is unusual. 2 Lingual fibrous hamartoma, a rare, most commonly congenital entity, is typically located at the midline of the base of tongue with variable size and shape. 2 It often decreases in size with advancing age, but it can also appear as a slowly growing mass causing dysphagia.…”

Section: Introductionmentioning

confidence: 99%

“…2 Lingual fibrous hamartoma, a rare, most commonly congenital entity, is typically located at the midline of the base of tongue with variable size and shape. 2 It often decreases in size with advancing age, but it can also appear as a slowly growing mass causing dysphagia. 2 An association with clefts of the lip and/ or palate has been reported.…”

Section: Introductionmentioning

confidence: 99%

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Congenital fibrous hamartoma of the tip of the tongue: A novel peculiar entity

Altobrando

Patrizi

Misciali

et al. 2020

Pediatric Dermatology

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Congenital fibrous hamartoma of the tip of the tongue, a peculiar and novel entity, consists of one or two asymptomatic pearly or yellowish nodules, not exceeding 0.5 cm in maximum diameter, at the tip of the tongue, ventrally or dorsally. Unlike other localizations, congenital fibrous hamartoma of the tip of the tongue is not associated with cleft lip or palate, or with feeding problems. Surgical excision should be avoided, reserved only for dubious cases, since the lesions are benign and stable over time.

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Lingual Hamartomas: Clinical Characteristics, Diagnostic Evaluation, Treatment, and Outcomes

et al. 2020

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Objectives/Hypothesis: To further clinically characterize lingual hamartomas, and to consolidate literature by analyzing clinical presentation, diagnostic evaluation, treatment, and outcomes.Study Design: Retrospective chart review and literature review. Methods: Case series from 1989 to 2020 at a tertiary pediatric center; follow-up ranging from 2 months to 12 years. Patient demographics, clinical presentations, physical examination findings, surgical pathology, operative methods, preoperative imaging, and follow-up. A review of English-language literature from 1945 to 2020 was conducted.Results: Seven patients (four male, three female) with nine lingual hamartomas were identified. Average age at surgical excision was 7.9 months (SD 3.5 months, range 3 to 14 months). Follow-up ranged from 2 months to 12 years, with all patients having no recurrence. Physical examination identified five pedunculated hamartomas and two sessile hamartomas. One patient had a neck CT, one had neck ultrasound, and two had facial MRIs. CT and ultrasounds confirmed presence of cervical thyroid. MRI suggested no muscular invasion for one patient, whereas motion artifact obscured findings for the other patient. Most patients who presented with dysphagia or poor weight gain achieved post-surgical improvement. The present cases combined with the literature review identified 57 patients with 63 lingual hamartomas.Conclusions: Lingual hamartomas appear as hypovascular pedunculated masses near the foramen cecum. There is no demographic predisposition, and most are identified during infancy. Imaging is not necessary, unless there is concern for lingual thyroid, in which case thyroid ultrasound should be performed. Surgical excision is curative, with dysphagia resolution and low likelihood for recurrence.

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Fibrous hamartoma of the tongue: report of a case with immunohistochemical and ultrastructural studies

Cited by 6 publications

References 19 publications

Nasopharyngeal leiomyomatous hamartoma: case report

Nasopharyngeal leiomyomatous hamartoma: case report

Congenital fibrous hamartoma of the tip of the tongue: A novel peculiar entity

Lingual Hamartomas: Clinical Characteristics, Diagnostic Evaluation, Treatment, and Outcomes

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