In view of its widespread application in aviation turbine fuel, diethyleneglycol monomethylether (DiEGME), and its interactions with water and n-heptane have been characterized using turbidity, interfacial tension, water activity and water absorption measurements. This additive has been implicated in a number of problems in recent years, which have arguably arisen from its various physico-chemical interactions with fuel and fuel system components, for which few data were hitherto available. The present study has therefore addressed the more fundamental aspects underlying such interactions using n-heptane as the hydrocarbon. Turbidity results indicate an increased level of water solubilization owing 2 to the formation of DiEGME-water clusters (~1:8 ratio) as the DiEGME concentration exceeds its specification maximum value of 0.15% (w/v) in fuel. Interestingly, this same composition is found in separated water resulting from additive partitioning from fuel leading to ~50% DiEGME/water mixtures. The combined use of interfacial tension, water activity and absorption measurements, and solubility parameters is able to explain this tendency as being due to a reduction in water activity in the presence of DiEGME, this latter property being reduced significantly above 50% DiEGME, which therefore appears to be the most thermodynamically-stable composition. Water activity considerations also provide the basis for understanding the action of DiEGME as a thermodynamic icing inhibitor, consistent with the role that hydrogen bonding plays in reducing water activity, and in line with water activity-based ice nucleation theory (Koop, T.; Luo, B.; Tsias, A.; Peter, T. Nature 2000, 406, 611-614).Correspondingly, the thermodynamic activity of DiEGME, derived herein using a Gibbs-Duhem treatment of water activity data, is shown to be reduced considerably in the presence of low levels of water (< 0.1 mole fraction), which would be sufficient to restrict the fuel solubility of this material as observed in practice.