2021
DOI: 10.3390/ijms22052430
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Fibrotic Phenotype of Peritumour Mesenteric Adipose Tissue in Human Colon Cancer: A Potential Hallmark of Metastatic Properties

Abstract: The impact of tumour associated stroma on cancer metastasis is an emerging field. However, cancer associated genes in peritumoral adipose tissue (pAT) in human colon cancer have not been explored. The aim of this study was to identify differentially expressed genes (DEGs) associated with cancer pathways in mesenteric pAT compared with adjacent adipose tissue. In total, nine patients with colon cancer pathological stage T2/T4 were employed in this study. DEGs were identified in 6 patients employing Nanostring P… Show more

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Cited by 9 publications
(5 citation statements)
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“…Therefore, this may also be one of the reasons for the significant decrease in XDH in calves with DHD. In addition, alpha-fetoprotein (AFP) ( 43 ), IGK protein ( 44 ), and collagen alpha-1 (I) chain precursor (COL1A1) ( 45 ) were also used as biomarkers for some intestinal diseases.…”
Section: Discussionmentioning
confidence: 99%
“…Therefore, this may also be one of the reasons for the significant decrease in XDH in calves with DHD. In addition, alpha-fetoprotein (AFP) ( 43 ), IGK protein ( 44 ), and collagen alpha-1 (I) chain precursor (COL1A1) ( 45 ) were also used as biomarkers for some intestinal diseases.…”
Section: Discussionmentioning
confidence: 99%
“…Several advanced stages of cancer, such as pancreatic cancer ( Vennin et al, 2015 ), breast cancer ( Nolan et al, 2020 ), colon cancer ( Tabuso et al, 2021 ), are characterized by a desmoplastic reaction, which is manifested by extensive deposition of fibrillar collagens in ECM, presenting thicker, more organized and more highly packed collagen fibers. Deposition of these fibers leads to typical stiff matrix of cancer ( Stylianopoulos et al, 2018 ), especially in the tumor regions nearby the BM, where increased fiber density can enhance the invasion of cancer cell ( Jurmeister et al, 2020 ) and cause the poor prognosis of several cancers such as breast cancer ( Bredfeldt et al, 2014 ), pancreatic cancer ( Drifka et al, 2016a ), gastric cancer ( Ohno et al, 2002 ), and oral squamous cell carcinomas ( Li et al, 2013 ).…”
Section: Extracellular Matrix In Cancermentioning
confidence: 99%
“…The lipid microenvironment around cancer cells is associated with CRC tumorigenesis, progression, and metastasis ( Castellano-Castillo et al, 2019 ). Peritumoral adipose tissue affects adipocytes, as well as immune and endothelial cells ( Tabuso et al, 2021 ). Therefore, among adipose metabolism disorders, a direct and independent relationship has been ascertained for some cancers, including CRC.…”
Section: Introductionmentioning
confidence: 99%