Fibrosis retroperitoneal asociada a neoplasias malignas: Serie de casos clínicos

Vega, Jorge; Ceriani, Alejandro; Jensen, Daniela

doi:10.4067/s0034-98872014000600015

Cited by 3 publications

(3 citation statements)

References 34 publications

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“…Retroperitoneal fibrosis is a rare condition of diverse etiology, associated with radiotherapy, aortic aneurysms, infections, and malignancy ( 29 ). Eight percent of cases are associated with malignancies ( 30 ). Common tumors leading to retroperitoneal fibrosis include breast, lung, gastrointestinal, genitourinary, thyroid, lymphoma, sarcoma, and carcinoid ( 31 ).…”

Section: Discussionmentioning

confidence: 99%

“…The pathogenic mechanism of peritoneal fibrosis induced by tumors is unknown. It may result from a desmoplastic reaction of the retroperitoneum to malignant cells, an inflammatory reaction, or cytokines secreted by the tumor ( 30 ). We have compiled a subset of cases presenting with tumor-associated retroperitoneal fibrosis, and the basic information and clinical details are summarized in Table 1 .…”

Section: Discussionmentioning

confidence: 99%

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Untypical bilateral breast cancer with peritoneal fibrosis on 18F-FDG PET/CT: case report and literature review

Song,

Qiu,

Huang

et al. 2024

Front. Med.

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BackgroundRetroperitoneal fibrosis, a condition of uncertain origin, is rarely linked to 8% of malignant cases, including breast, lung, gastrointestinal, genitourinary, thyroid, and carcinoid. The mechanism leading to peritoneal fibrosis induced by tumors is not well understood, possibly encompassing direct infiltration of neoplastic cells or the initiation of inflammatory responses prompted by cytokines released by tumor cells. We report a case of breast cancer with renal metastasis and retroperitoneal fibrosis detected using 18F-FDG PET/CT, providing help for clinical diagnosis and treatment.Case reportA 49-year-old woman was referred to the hospital with elevated creatinine and oliguria for over a month. Abdominal computer tomography (CT) and magnetic resonance imaging (MRI) showed a retroperitoneal fibrosis-induced acute kidney injury (AKI) was suspected. However, a percutaneous biopsy of the kidney lesion confirmed metastasis from breast cancer. The physical examination revealed inverted nipples and an orange peel appearance on the skin of both breasts. Ultrasonography revealed bilateral hyperplasia (BIRADS 4a) of the mammary glands and bilateral neck and axillary lymphadenopathy. Subsequently, 18F-deoxyglucose positron emission tomography/computer tomography (18F-FDG PET/CT) detected abnormally high uptake (SUVmax) in the bilateral mammary glands and axillary lymph nodes, suggesting bilateral breast cancer. Furthermore, abnormal 18F-FDG uptake was detected in the kidney, suggesting renal metastasis. In addition, abnormal 18F-FDG uptake was observed in the vertebrae, accompanied by an elevation in inhomogeneous bone mineral density, raising suspicion of bone metastases. However, the possibility of myelodysplasia cannot be dismissed, and further investigations will be conducted during close follow-ups. There was significant 18F-FDG uptake in the retroperitoneal position indicating a potential association between retroperitoneal fibrosis and breast cancer. The final pathological diagnosis of the breast tissue confirmed bilateral invasive ductal carcinoma. The patient had been treated with 11 cycles of albumin-bound (nab)-paclitaxel (0.3 mg) and had no significant adverse reaction.ConclusionIn this case, neither the bilateral breast cancer nor the kidney metastatic lesion showed typical nodules or masses, so breast ultrasound, abdominal CT, and MRI did not suggest malignant lesions. PET/CT played an important role in detecting occult metastases and primary lesions, thereby contributing to more accurate staging, monitoring treatment responses, and prediction of prognosis in breast cancer.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Untypical bilateral breast cancer with peritoneal fibrosis on 18F-FDG PET/CT: case report and literature review

Song,

Qiu,

Huang

et al. 2024

Front. Med.

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“…The patient's laboratory values improved notably and a new MDCT of the abdomen and pelvis with intravenous contrast was performed 3 months after hospital discharge, where the retroperitoneal image described above was no longer evident (Figure 3 and 4). [1][2][3][4][5][6][7][8] Figure 3 MDCT with intravenous contrast, arterial phase, axial view. There is evidence of free retroperitoneum without formation, aorta with contrast.…”

Section: An Abdominal Ultrasound Was Requested On Admission Showing B...mentioning

confidence: 99%

Retroperitoneal fibrosis - case report

Fredes¹

2022

IJRRT

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Retroperitoneal fibrosis (RPF) is a rare entity that consists of chronic, non-specific inflammation of the retroperitoneum with proliferation of fibrotic tissue surrounding the aorta, inferior vena cava, iliac vessels, and generally encompasses and compresses the ureters. It can be primary idiopathic or secondary to drugs, neoplasms, previous radiotherapy among others. The average age of onset is between 40 and 70 years with a slight male predominance. The clinical manifestations are non-specific, so it is frequently diagnosed in advanced stages. The initial symptoms consist of low back pain, asthenia, weight loss, arterial hypertension and in advanced stages obstructive renal failure is associated. MDCT (multidetector computed tomography) is the first line diagnostic method where it is possible to evaluate the extension of the fibrous mass as well as the involvement of adjacent structures, detect hydronephrosis or secondary causes.

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Thinking Beyond Acute Kidney Injury

El-Alali

Moreno

Jaber

2022

Case Rep Nephrol Dial

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Acute kidney injury (AKI) can be a significant clue to solving a puzzling patient presentation. Postrenal AKI should be suspected if imaging shows any degree of hydronephrosis and can be caused by a variety of conditions. Diagnosis of urinary obstruction without significant dilatation of the pelvic-ureteral system requires a higher degree of suspicion, and hence, its identification can become late. In patients without prior cancer screening, the etiology of obstructive uropathy must be broadened to include primary or metastatic malignancy. Clinicians should look beyond the AKI to properly evaluate the etiology of the patient’s presentation and symptoms. In this report, we present the case of a middle-aged female with no known past medical history who presented with AKI secondary to malignant retroperitoneal fibrosis as the first manifestation of metastatic breast cancer. Her AKI was associated with acute onset anuria and was found to have nondilated postrenal AKI with no significant abnormalities on renal imaging. Early onset anuria in the setting of AKI, which persists despite fluid resuscitation, can suggest complete urinary tract obstruction even with reassuring results of initial renal images, and in the patient with no history of cancer screening, malignancy should be suspected as a primary cause of obstructive uropathy.

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Fibrosis retroperitoneal asociada a neoplasias malignas: Serie de casos clínicos

Cited by 3 publications

References 34 publications

Untypical bilateral breast cancer with peritoneal fibrosis on 18F-FDG PET/CT: case report and literature review

Untypical bilateral breast cancer with peritoneal fibrosis on 18F-FDG PET/CT: case report and literature review

Retroperitoneal fibrosis - case report

Thinking Beyond Acute Kidney Injury

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