Fibrosis endomiocárdica

Villamil-Munévar, Alejandro; Barbosa, Christian; Ternera-Barrios, Alfonso; Pinedo, Jorge Luis; Olaya, Alejandro

doi:10.1016/j.rccar.2016.09.006

Cited by 4 publications

(3 citation statements)

References 12 publications

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“…Reports are scarce in Latin America 2 , and existing evidence comes from Brazil and Colombia; in the latter country there are three case reports [4][5][6] with similar characteristics to those described in patients from the African continent.…”

Section: Introductionmentioning

confidence: 90%

Endomyocardial fibrosis: A restrictive cardiomyopathy in developing countries

Vasquez-Rodriguez¹,

Medina-Mur²,

Giraldo³

et al. 2021

ACME

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Objective: Endomyocardial fibrosis (EF) is an unusual restrictive cardiomyopathy. In Latin America there are few reports.Here, we made a description of patients diagnosed with EF in Colombia. Method: We conducted a search in the records of cardiac magnetic resonance imaging (MRI) performed in our institution between 2016-2019 looking for patients with a diagnosis of EF; sociodemographic, clinical and imaging characteristics were described. Results: Nine patients were diagnosed with EF (66.7% female), with an average age of 69 years. Patients presented an average evolution of 2.6 years. The main reported symptom was dyspnea, followed by syncope, chest pain, and palpitations. None of them was initially suspected for EF. Regarding echocardiographic findings, predominant left ventricular involvement was identified, followed by bi-ventricular involvement. All the patients presented a restrictive filling pattern with severe left atrial dilation. In a retrospective analysis, Mocumbi criteria for diagnosis of EF were met in 100% of the patients, majority with moderate severity (77.8%). Cardiac MRI showed biventricular systolic function and volumes preserved. Focal subendocardial late gadolinium enhancement was observed on the apex and apical thrombus was confirmed in 66% of the patients. Conclusion: FE is an uncommon restrictive cardiomyopathy limited to tropical countries. Most of patients in our series presented isolated involvement of left ventricle, followed by bi-ventricular involvement, with ventricular function usually preserved.

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Section: Introductionmentioning

confidence: 90%

Endomyocardial fibrosis: A restrictive cardiomyopathy in developing countries

Vasquez-Rodriguez¹,

Medina-Mur²,

Giraldo³

et al. 2021

ACME

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“…En América Latina son escasos los reportes 2 y la evidencia existente proviene de Brasil y Colombia; en este último país hay tres reportes de caso [4][5][6] con características similares a las descritas en pacientes del continente africano.…”

Section: Introducciónunclassified

Fibrosis endomiocárdica: una cardiomiopatía restrictiva en países en vía de desarrollo

Vasquez-Rodriguez¹,

Medina-Mur²,

Giraldo³

et al. 2021

ACM

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La fibrosis endomiocárdica (FE) es una cardiomiopatía restrictiva infrecuente. En América Latina son escasos los reportes. En el presente trabajo se realiza una descripción de una serie de pacientes diagnosticados de FE en Colombia. Método: Realizamos una búsqueda en los registros de imágenes de resonancia magnética (RM) cardiaca realizadas en nuestra institución entre 2016 y 2019 en busca de pacientes con diagnóstico de FE. Se describieron sus características sociodemográficas, clínicas y de imagen. Resultados: Nueve pacientes fueron diagnosticados de FE (el 66.7% mujeres), con una edad promedio de 69 años. Los pacientes presentaron un promedio de 2.6 años de evolución. El principal síntoma referido fue disnea, seguido de síncope, dolor torácico y palpitaciones. En ninguno de ellos se sospechó FE como diagnóstico inicial. En cuanto a los hallazgos ecocardiográficos, se identificó compromiso predominante del ventrículo izquierdo, seguido de compromiso biventricular. Todos los pacientes presentaron patrón de llenado restrictivo con dilatación auricular izquierda severa. En el análisis retrospectivo se cumplieron los criterios de Mocumbi para el diagnóstico de FE en el 100% de los pacientes con gravedad moderada (77.8%). Las imágenes de RM mostraron función sistólica biventricular y volúmenes preservados. Se observó depósito focal de gadolinio subendocárdico a nivel apical y se confirmó la presencia de trombo en el 66% de los casos. Conclusión: La FE es una cardiomiopatía restrictiva infrecuente circunscrita a países tropicales. La mayoría de los pacientes en nuestra serie presentaron compromiso aislado del ventrículo izquierdo, seguido de compromiso biventricular, con función ventricular usualmente preservada.

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“…EMF arises as a result of the accumulation of collagen deposits in the ECM, as a consequence of the evolution of various pathologies such as coronary failure, infectious, and autoimmune diseases, among others [12,13]. Fibrillar collagen is the main component accumulated during the cardiac fibrosis process.…”

Section: Introductionmentioning

confidence: 99%

Development of endomyocardial fibrosis model using a cell patterning technique: In vitro interaction of cell coculture of 3T3 fibroblasts and RL-14 cardiomyocytes

2020

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Cardiac functions can be altered by changes in the microstructure of the heart, i.e., remodeling of the cardiac tissue, which may activate pathologies such as hypertrophy, dilation, or cardiac fibrosis. Cardiac fibrosis can develop due to an excessive deposition of extracellular matrix proteins, which are products of the activation of fibroblasts. In this context, the anatomical-histological change may interfere with the functioning of the cardiac tissue, which requires specialized cells for its operation. The purpose of the present study was to determine the cellular interactions and morphological changes in cocultures of 3T3 fibroblasts and RL-14 cardiomyocytes via the generation of a platform an in vitro model. For this purpose, a platform emulating the biological characteristics of endomyocardial fibrosis was generated using a cell patterning technique to study morphological cellular changes in compact and irregular patterns of fibrosis. It was found that cellular patterns emulating the geometrical distributions of endomyocardial fibrosis generated morphological changes after interaction of the RL-14 cardiomyocytes with the 3T3 fibroblasts. Through this study, it was possible to evaluate biological characteristics such as cell proliferation, adhesion, and spatial distribution, which are directly related to the type of emulated endomyocardial fibrosis. This research concluded that fibroblasts inhibited the proliferation of cardiomyocytes via their interaction with specific microarchitectures. This behavior is consistent with the histopathological distribution of cardiac fibrosis; therefore, the platform developed in this research could be useful for the in vitro assessment of cellular microdomains. This would allow for the experimental determination of interactions with drugs, substrates, or biomaterials within the engineering of cardiac tissues.

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Fibrosis endomiocárdica

Cited by 4 publications

References 12 publications

Endomyocardial fibrosis: A restrictive cardiomyopathy in developing countries

Endomyocardial fibrosis: A restrictive cardiomyopathy in developing countries

Fibrosis endomiocárdica: una cardiomiopatía restrictiva en países en vía de desarrollo

Development of endomyocardial fibrosis model using a cell patterning technique: In vitro interaction of cell coculture of 3T3 fibroblasts and RL-14 cardiomyocytes

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