Fibrosarcoma arising in an ovarian mucinous tumor: a case report

Rahilly, Maeve A.; Candlish, W.; Al‐Nafussi, Awatif

doi:10.1046/j.1525-1438.1994.04030211.x

Cited by 9 publications

(7 citation statements)

References 2 publications

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“…A review of the literature revealed only five mucinous ovarian tumors with sarcomas, with most of the mural nodules measured > 5 cm in the greatest dimension. In these five cases, they were fibrosarcomatous mural nodule in an ovarian mucinous cystadenoma [ 7 ], fibrosarcoma arising in a mucinous cystadenocarcinoma [ 8 ], fibrosarcoma associated with a mucinous cystadenoma [ 9 ], undifferentiated sarcoma in a mucinous cystadenocarcinoma [ 9 ], and rhabdomyosarcoma coexistent with ovarian mucinous cystadenocarcinoma [ 10 ], respectively. Ovarian mucinous borderline tumor accompanied by LGESS with myxoid change in our case was rather unique.…”

Section: Discussionmentioning

confidence: 99%

Ovarian mucinous borderline tumor accompanied by LGESS with myxoid change: a case report and literature review

et al. 2017

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ObjectivesTo report an extremely rare case of ovarian borderline mucinous cystic tumor accompanied by low-grade endometrial stromal sarcoma (LGESS) with myxoid change.Case presentationA 42-year-old woman complained of lower left abdominal fullness. Her serum carcinoembryonic antigen, cancer antigen (CA) 125, and CA19-9 levels were normal. Magnetic resonance imaging showed a 10-cm cystic mass with a 5-cm nodule in its wall, and a laparoscopy indicated a cystic mass at the left adnexa. Histology indicated a cystic lesion consisting of proliferative gastrointestinal-type epithelium; the mural nodule had a characteristic of striking myxoid change, preservation of arteriolar pattern, and a “tongue-like” infiltration.ConclusionsThe diagnosis of ovarian mucinous borderline tumor accompanied by LGESS with myxoid change was appropriate.

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Section: Discussionmentioning

confidence: 99%

Ovarian mucinous borderline tumor accompanied by LGESS with myxoid change: a case report and literature review

et al. 2017

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“…In this case, the cell line was established from a sarcomatous mural nodule of a borderline mucinous cystadenoma. In rare instances, cystic ovarian mucinous tumors contain spindle cell mural nodules (SCMN) (12–31) . These SCMN have been reported to include sarcomas (12,18–21,27) , reactive sarcoma‐like nodules (13,17,24,29) , anaplastic carcinomas (14–18,23,25,26,30,31) , combined sarcoma‐like nodules and carcinomas (17,22) , and leiomyomas (20,23,28) .…”

Section: Discussionmentioning

confidence: 99%

“…In rare instances, cystic ovarian mucinous tumors contain spindle cell mural nodules (SCMN) (12231) . These SCMN have been reported to include sarcomas (12,18221,27) , reactive sarcoma-like nodules (13,17,24,29) , anaplastic carcinomas (14218,23,25,26,30,31) , combined sarcoma-like nodules and carcinomas (17,22) , and leiomyomas (20,23,28) . Thus, the prognosis of the ovarian tumor can be dramatically modified by the presence of this nodule.…”

Section: Discussionmentioning

confidence: 99%

“…Sarcomatoid carcinoma is a rather uncommon malignant tumor of the female genital tract. Although there have been many histologic studies (12–31) , the histogenesis of sarcomatoid carcinoma is still unknown. This study describes the cell morphology, growth properties, chromosomal analysis, agglutination test, and tumorgenicity as well as antigen and marker expression of this unusual tumor cell line.…”

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confidence: 99%

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Establishment and characterization of a human ovarian sarcomatoid carcinoma cell line BUPH:OVSC

Guo¹,

Feng²,

Liu³

et al. 2005

Int J Gynecol Cancer

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We first established a human ovarian sarcomatoid carcinoma cell line designated BUPH:OVSC from primary culture. The specimen was derived from the mural nodule in an ovarian mucinous tumor and cultured in vitro. To date, the cell line has been maintained for over 100 passages. Its biologic characteristics were studied by light and electron microscopy, which revealed spindle-shaped or polygonal cells with a doubling time of 39.5 h. The agglutination test of BUPH:OVSC was positive, and cell colonies were formed in soft agar. Chromosome analysis revealed its karyotype to be a pseudodiploidy. One X chromosome deletion and chromosome 20 addition were detected, and aberrant chromosomes t (1q;12q) and 14p(+) were its chromosome markers. BUPH:OVSC was tumorigenic in nude mice. Hematoxylin and eosin staining of transplanted tumors showed that the cells were morphologically sarcomatoid. However, the transmission electron microscopic observation exposed its epithelial origin. The cell line coexpresses cytokeratin and vimentin. It dose not appear to express estrogen and progesterone receptors or the CA125 tumor marker. Alcian blue/periodic acid-Schiff staining indicates that the cells could secrete acid mucopolysaccharide. In conclusion, BUPH:OVSC displays unique cellular properties, which make it a useful model for the study of human ovarian sarcomatoid carcinomas.

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“…Rarely, fibrosarcoma is associated with Mafucci's syndrome 7 or the naevoid basal cell carcinoma syndrome 8 . Fibrosarcomas have also been described within an ovarian mucinous neoplasm 9,10 . In the present case, although there was no marked nuclear pleomorphism or evidence of tumour cell necrosis, a diagnosis of malignancy was made because of the high mitotic rate.…”

Section: Discussionmentioning

confidence: 99%

Ovarian fibrosarcoma with androgenic manifestations: a rare association

McCluggage

Kilgallen

MaWhinney

et al. 2002

BJOG

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Case reportA 21 year old obese nulliparous woman attended with irregular menstruation and recent onset of hirsutism. An ultrasound scan of her pelvis and abdomen revealed a solid mass in the right ovary measuring 6 cm in diameter. A serum androgen profile showed an increased testosterone level of 4.0 nmol/l. The serum concentrations of aFP, CA125 and hHCG were within the normal ranges. At laparotomy, an enlarged right ovary measuring 6 cm in diameter was removed. The uterus and left ovary appeared normal and were conserved. Postoperative computed tomography scan of abdomen and pelvis revealed no abnormality and a repeat serum androgen profile was normal. At laparoscopy two months after the original surgery, pelvic lymph node dissection and peritoneal washings were performed and a wedge biopsy of the left ovary was taken.The surgical specimen consisted of a right ovary weighing 83 g and measuring 6 Â 5 Â 4.5 cm. The capsular surface was largely smooth although a capsular tear 1.5 cm in length was present. Sectioning the ovary revealed a firm solid white lesion.Histology showed a cellular neoplasm composed of cells with spindle shaped nuclei and scanty cytoplasm. There was only mild nuclear pleomorphism and no necrosis was seen. Many mitotic figures were identified (Fig. 1a), a formal mitotic count revealing an average of 20 mitoses per 10 high power fields. Several collections of luteinised stromal cells with abundant eosinophilic cytoplasm (Fig. 1b) were scattered throughout the tumour. The histologic diagnosis was of a fibrosarcoma.Pathologic examination of the pelvic lymph nodes, the peritoneal washings and the wedge biopsy of the left ovary performed at the laparoscopy showed no tumour infiltration. DiscussionPrimary pure sarcomas of the ovary are rare although a sarcomatous component may occur as part of an ovarian carcinosarcoma (malignant mixed Mullerian tumour).

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Fibrosarcoma arising in an ovarian mucinous tumor: a case report

Cited by 9 publications

References 2 publications

Ovarian mucinous borderline tumor accompanied by LGESS with myxoid change: a case report and literature review

Ovarian mucinous borderline tumor accompanied by LGESS with myxoid change: a case report and literature review

Establishment and characterization of a human ovarian sarcomatoid carcinoma cell line BUPH:OVSC

Ovarian fibrosarcoma with androgenic manifestations: a rare association

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