Fibromyalgia: epidemiology and risk factors, a population-based case-control study in Lebanon

Moukaddem, Afaf; Chaaya, Monique; Jaffa, Miran A.; Sibai, Abla Mehio; Uthman, Imad

doi:10.1111/1756-185x.12701

Cited by 7 publications

(14 citation statements)

References 34 publications

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“…The characteristic features of the FM patients are in agreement with other studies that showed a positive family history and smoking. [ 22 23 ] These observations indicate that FM is a disease that related to the genetic disorder, and the smoking behavior is a reaction to stress. The values of MPV and platelet width distribution were significantly higher in FM patients than healthy individuals.…”

Section: Discussionmentioning

confidence: 99%

Serum levels of serotonin as a biomarker of newly diagnosed fibromyalgia in women: Its relation to the platelet indices

2018

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Background:This study aimed to assess the serum serotonin levels in the newly diagnosed fibromyalgia (FM) and to relate these levels to the presenting signs and symptoms.Materials and Methods:This case–control study included 35 healthy women (Group I) served as controls and 130 women with newly diagnosed FM (Group II). The diagnosis of FM was confirmed by the diagnostic criteria of the American College of Rheumatology-10. The assessment of pain using a revised fibromyalgia impact questionnaire and tender points scoring, blood platelet indices, and serum serotonin levels were determined.Results:Group II patients had significantly (P < 0.001) higher values of mean platelet volume (MPV) (10.60 ± 1.57fL) and platelet width distribution (16.25 ± 1.45%) than the corresponding values in Group I (8.73 ± 0.81fL and 15.0 ± 1.15%). Significant low-serum serotonin levels observed in Group II patients compared with Group I healthy individuals (187.3 ± 50.3 ng/ml vs. 219.5 ± 78.3 ng/ml, P = 0.026). Multiple linear regression analysis showed the nonsignificant correlations between serum serotonin levels and platelet indices in Group II patients.Conclusion:Newly diagnosed FM women have significantly low-serum serotonin levels, which does not correlate with a significant increment of the platelet activity expressed as increase MPV and platelet width distribution percentage. Therefore, this study highlighted that the correction of serum serotonin level by medicines could help the patients.

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Section: Discussionmentioning

confidence: 99%

Serum levels of serotonin as a biomarker of newly diagnosed fibromyalgia in women: Its relation to the platelet indices

2018

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“…A similar observation was made in a study conducted in Lebanon, as all FM cases were previously misdiagnosed and did not receive a diagnosis of FM. [13] The diagnosis of FM requires the efforts of patients to seek medical care and clinicians who are familiar with the disease and are willing to make the diagnosis, as FM diagnosis is confounded by drug-seeking behavior and malingering. [31] Our study shows that females have greater odds to have FM (OR=1.7), which goes in line with the literature.…”

Section: Discussionmentioning

confidence: 99%

“…[31] Our study shows that females have greater odds to have FM (OR=1.7), which goes in line with the literature. [9,[11][12][13] Having health insurance is shown to be a risk factor in our population, probably because health insurance is not common in Syria, as only 14.1% of our sample have it. In addition, this insurance is offered to the workers in the public sector that have low wages due to economical in ation.…”

Section: Discussionmentioning

confidence: 99%

“…[11] Another study in Germany estimated the prevalence at 3.8%, with similar rates in men and women, while in Lebanon, Syria's neighboring country, the prevalence of FM was found to be 7%. [12,13] These differing estimations may re ect differences in study populations, study designs, and measurements. As a result, prevalence estimations can vary, up to 4-folds, depending on the diagnostic criteria applied, which at times exceeded 15% in selected samples.…”

Section: Introductionmentioning

confidence: 99%

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Fibromyalgia: epidemiology and risk factors, a population-based case-control study in Damascus, Syria.

Alzabibi

Shibani

Alsuliman

et al. 2021

Preprint

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Background Fibromyalgia is a chronic disease with a high burden. We aim to be the first to investigate the prevalence of fibromyalgia (FM) in Syria and assess its risk factors. Methods a self-reported questionnaire was distributed to the public to identify fibromyalgia patients using the American College of Rheumatology (ACR) 2010 modified criteria. Identified cases were matched using age with controls free from rheumatic disorders that were randomly sampled from the same population. Results out of 2966 participants, 350 (11.8%) satisfied the diagnostic criteria. Of these, only 29 (8.2%) were previously diagnosed by a physician, 239 (68.3%) were females, and 69 (19.71%) were diagnosed with depression. Female sex (OR=1.7, CI: 1.3-2.1), unemployment (OR=1.4, CI:1.1 – 1.79), diagnosis of major depressive disorder (OR=3.8, CI: 2.7 – 5.35), generalized anxiety disorder (OR=2.7, CI: 1.95 – 3.72), and irritable bowel syndrome (OR=2.4, CI: 1.78 – 3.17) were significant risk factors for FM. Conclusion our study revealed one of the highest prevalence rates of fibromyalgia ever reported in the general population. Efforts must be intensified to increase the awareness about this disease in the Syrian society as well as among healthcare providers.

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“…With respect to the age of patients with FM Moukaddem et al (2017), they found that 58.8% of the sample (20 patients) were between 30 and 49 years old, while 29.4% (10 patients) were > 50 years (Moukaddem et al, 2017). The data of this study support the figures described in relation to the prevalence of FM in different age groups, the majority being between 49-58 years, followed by the group between 39-58 years (McNally, Matheson, & Bakowsky, 2006;Moukaddem et al, 2015;Queiroz, 2013).…”

Section: Discussionmentioning

confidence: 99%

Screening of Anxiety and Depression in Patients With Fibromyalgia From 18 to 65 Years Old and Its Relationship With the Severity of Fibromyalgia and Quality of Life

Gonzalez¹,

Illera²,

Cárdenas³

et al. 2018

GJHS

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OBJECTIVE: To identify the relationship between anxiety and depression with the severity of fibromyalgia and quality of life in patients aged 18 to 65 years, clinic of rheumatology of Barranquilla. METHODS: Observational, descriptive, comparative cross-sectional study. Patients with fibromyalgia who attend the external consultation of rheumatology will be surveyed. The questionnaires to be applied are the Fibromyalgia Impact Questionnaire Revised (Spanish version), Health Questionnaire SF-36, Patient Health Questionnaire and a Scale of 7 questions for generalized anxiety disorder. The data collected in this descriptive study will be analyzed by means of frequency and association measures. The analysis of association between sociodemographic factors and clinical characteristics will be carried out with bivariate analysis and the comparison of qualitative or categorical variables will be done through the analysis of variance, to compare variables of ordinal type and variables of type ratio. RESULTS: 34.2% of the patients did not present anxiety whereas 83.6% of the patients had some degree of depression. 50% of the patients had moderate, severe and extreme degrees of depression. An association was found between severity of fibromyalgia with anxiety, depression and quality of life (p <0.05). CONCLUSION: A directly proportional relationship was found between the severity of depression and anxiety and the severity of FM. An elevated score in the FIQR, lower weighted scores for quality of life in the participants, in addition to greater severity in the scales GAD - 7 and PHQ - 9, all score to lower quality of life.

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Fibromyalgia: epidemiology and risk factors, a population-based case-control study in Lebanon

Cited by 7 publications

References 34 publications

Serum levels of serotonin as a biomarker of newly diagnosed fibromyalgia in women: Its relation to the platelet indices

Serum levels of serotonin as a biomarker of newly diagnosed fibromyalgia in women: Its relation to the platelet indices

Fibromyalgia: epidemiology and risk factors, a population-based case-control study in Damascus, Syria.

Screening of Anxiety and Depression in Patients With Fibromyalgia From 18 to 65 Years Old and Its Relationship With the Severity of Fibromyalgia and Quality of Life

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