Introduction
Different factors are critical when assessing COVID-19 mortality, and can explain why severity differs so widely among populations. However, there is little information regarding prognostic factors and mortality in COVID-19 from Latin American countries.
Objectives
To determine prognostic factors in hospitalized COVID-19 patients and to evaluate the impact of tocilizumab use in patients with hyperinflammatory syndrome and severe disease defined by the National Early Warning Score 2 (NEWS2) with a value greater than or equal to seven points.
Materials and methods
This retrospective cohort study included hospitalized COVID-19 patients from May to July 2020. A multivariate logistic regression analysis was performed to determine independent factors associated with mortality.
Results
A total of 136 patients required hospital admission. In-hospital mortality was 39.7%. Mortality was observed to be potentiated by older age, LDH serum levels and the presence of type 2 diabetes mellitus. Lymphopenia and lower PaO2/FiO2 ratio were more common in these patients. Similarly, patients who died were classified more frequently with severe disease. The independent factors associated with in-hospital mortality were age greater than 65 years, type 2 diabetes mellitus, NEWS2 greater than or equal to seven points and LDH greater than 400U/L. The use of Tocilizumab alone was not related with decreased in-hospital mortality. Subgroup analysis performed in patients with hyperinflammation and severe disease showed similar results.
Conclusions
COVID-19 mortality in hospitalized patients was high and mainly related with older age, comorbidities, LDH and the severity of disease at hospital admission.
O estado pró-inflamatório induzido por bebidas açucaradas, por exemplo, desempenha um papel fundamental na patogênese da artrite reumatoide (AR), entre outras condições que foram demonstradas ao longo dos anos por diversas pesquisas.
Desarrollar una vacuna o cualquier fármaco para el consumo humano requiere del cumplimento de un proceso con unos tiempos de ejecución establecidos. No es una tarea fácil.
Publicações recentes mostram outros vencedores inesperados nesta luta contra os vírus: são as misturas preparadas pelas avós desde tempos imemoriais à base de frutas cítricas
El estado pro inflamatorio inducido por las bebidas azucaradas, por ejemplo, juega un papel clave en la patogenia de la artritis reumatoide (AR), entre otras afectaciones que han sido demostradas a lo largo de los años por diversas investigaciones.
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