Fibromyalgia and periodontitis: Bidirectional associations in population‐based 15‐year retrospective cohorts

Sheng-Kai, Kevin; Lai, Jung‐Nien; Veeravalli, John Jims; Chiu, Lu-Ting; Dyke, Thomas E. Van; Wei, James Cheng‐Chung

doi:10.1002/jper.21-0256

Cited by 31 publications

(31 citation statements)

References 50 publications

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“…Clinical presentation of PD involves progressive destruction of the periodontium, followed by pocket formation, gingival recession, alveolar bone loss, tooth mobility, and ultimately tooth loss (Slots 2017). The interaction between PD and inflammatory diseases has been proposed (Ma, Chiang, Chen, and Wang 2021;Ma, Chiang, Lopez, and Wang 2021;Ma, Lai, Veeravalli, Chiu, Van Dyke, and Wei 2021). Following PD, tooth loss is the second strongly associated oral condition with AD and/or dementia (Li et al 2000).…”

Section: Introductionmentioning

confidence: 99%

Dementia and the Risk of Periodontitis: A Population-Based Cohort Study

Sheng‐Kai

Hastürk²,

Carreras

et al. 2021

J Dent Res

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Dementia and Alzheimer’s disease (AD) are proposed to be comorbid with periodontitis (PD). It is unclear whether PD is associated with dementia and AD independent of confounding factors. We aimed at identifying the relationship between the longitudinal risk of developing PD in a cohort of patients with dementia and AD who did not show any signs of PD at baseline. In this retrospective cohort study, 8,640 patients with dementia without prior PD were recruited, and 8,640 individuals without dementia history were selected as propensity score–matched controls. A Cox proportional hazard model was developed to estimate the risk of developing PD over 10 y. Cumulative probability was derived to assess the time-dependent effect of dementia on PD. Of the 8,640 patients, a sensitivity test was conducted on 606 patients with AD-associated dementia and 606 non-AD propensity score–matched controls to identify the impact of AD-associated dementia on the risk for PD. Subgroup analyses on age stratification were included. Overall 2,670 patients with dementia developed PD. The relative risk of PD in these patients was significantly higher than in the nondementia group (1.825, 95% CI = 1.715 to 1.942). Cox proportional hazard models showed that patients with dementia were more likely to have PD than individuals without dementia (adjusted hazard ratio = 1.915, 95% CI = 1.766 to 2.077, P < 0.0001, log-rank test P < 0.0001). The risk of PD in patients with dementia was age dependent ( P values for all ages <0.0001); younger patients with dementia were more likely to develop PD. The findings persisted for patients with AD: the relative risk (1.531, 95% CI = 1.209 to 1.939) and adjusted hazard ratio (1.667, 95% CI = 1.244 to 2.232; log-rank test P = 0.0004) of PD in patients with AD were significantly higher than the non-AD cohort. Our findings demonstrated that dementia and AD were associated with a higher risk of PD dependent of age and independent of systemic confounding factors.

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Section: Introductionmentioning

confidence: 99%

Dementia and the Risk of Periodontitis: A Population-Based Cohort Study

Sheng‐Kai

Hastürk²,

Carreras

et al. 2021

J Dent Res

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“…To assure the validity and consistency of the diagnosis used in the cohort, both osteoarthritis and periodontitis were confirmed in at least two outpatient visits or at least one inpatient discharge note within one year; all medical records, along with the diagnoses, were peer-reviewed for quality control by rheumatologists and dentists, respectively. Moreover, the validity of diagnoses has been confirmed in previous studies (31)(32)(33).The database was de-identified, and the current study was approved by the Institutional Review Board of Chung Shan Medical University Hospital (approval number CS15134).…”

Section: Study Design and Data Sourcesmentioning

confidence: 58%

Bidirectional Relationship Between Osteoarthritis and Periodontitis: A Population-Based Cohort Study Over a 15-year Follow-Up

et al. 2022

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ObjectiveTo identify the relationship between osteoarthritis and periodontitis.Methods144,788 periodontitis patients and 144,788 propensity score-matched controls without history of periodontitis were enrolled in this cohort study. A Cox proportional hazard model was used to estimate the risk of osteoarthritis. Survival analysis was utilized to assess the time-dependent effect of periodontitis on osteoarthritis. Age and gender were stratified to identify subgroups at risk. A symmetrical case-control analysis was designed to determine the relationship between present periodontitis and history of osteoarthritis.ResultsPatients with periodontitis had higher risk of osteoarthritis (hazard ratio, HR =1.15, 95% CI =1.12–1.17, p < 0.001) and severe osteoarthritis that led to total knee replacement or total hip replacement (TKR/THR) (HR =1.12, 95% CI =1.03–1.21, p < 0.01) than controls, which was time-dependent (log-rank test p < 0.01). The effect of periodontitis on osteoarthritis was significant in both genders and age subgroups over 30 years-old (all p < 0.001). Among them, females (HR=1.27, 95% CI = 1.13–1.42, p < 0.001) and patients aged over 51 (HR= 1.21, 95% CI =1.10-1.33, p < 0.001) with periodontitis were predisposed to severe osteoarthritis. In addition, periodontitis patients were more likely to have a history of osteoarthritis (odds ratio = 1.11, 95% CI = 1.06 - 1.17, p < 0.001).ConclusionsThese findings suggest an association between periodontitis and a higher risk of osteoarthritis, including severe osteoarthritis that led to TKR/THR. Likewise, periodontitis is more likely to develop following osteoarthritis. A bidirectional relationship between osteoarthritis and periodontitis was observed.

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“…In this cohort study, we employed a nationwide population-based registry to provide epidemiological evidence on the risks of new-onset ED in patients with HPV infection. The effect of measurable confounders was minimized by PS matching [ 71 , 72 , 73 , 74 , 75 ]. Sensitivity and negative control analyses were conducted to manage residual confounding and to ascertain the impact of HPV infection on ED development.…”

Section: Discussionmentioning

confidence: 99%

Human Papillomavirus Infection and the Risk of Erectile Dysfunction: A Nationwide Population-Based Matched Cohort Study

Juang

Sheng‐Kai

Kao

et al. 2022

JPM

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Background: Male patients with genital warts are known for higher rates of sexual dysfunction. This study was conducted to investigate whether human papillomaviruses (HPV) infection is associated with an increased risk of erectile dysfunction (ED). Methods: Patients aged over 18 with HPV infection (n = 13,296) and propensity score-matched controls (n = 53,184) were recruited from the Longitudinal Health Insurance Database (LHID). The primary endpoint was the diagnosis of ED. Chi-square tests were used to analyze the distribution of demographic characteristics. The Cox proportional hazards regression was used to estimate the hazard ratios (HRs) and 95% confidence intervals (CIs) for the development of ED in both groups, after adjusting for sex, age, relevant comorbidities, co-medication, and surgery. Results: ED developed in 181 patients of the study group. The incidence density of ED was 2.53 per 1000 person-years for the HPV group and 1.51 per 1000 person-years for the non-HPV group, with an adjusted HR (95% CI) of 1.63 (1.37–1.94). In stratification analysis, adjusted HR of diabetes-, chronic obstructive pulmonary disease (COPD-), and stroke-subgroup were 2.39, 2.51, and 4.82, with significant p values for interaction, respectively. Sensitivity analysis yields consistent findings. Conclusions: The patients with HPV infection had a higher risk of subsequent ED in comparison to the non-HPV controls. The mechanism behind such association and its possible role in ED prevention deserves further study in the future.

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Fibromyalgia and periodontitis: Bidirectional associations in population‐based 15‐year retrospective cohorts

Cited by 31 publications

References 50 publications

Dementia and the Risk of Periodontitis: A Population-Based Cohort Study

Dementia and the Risk of Periodontitis: A Population-Based Cohort Study

Bidirectional Relationship Between Osteoarthritis and Periodontitis: A Population-Based Cohort Study Over a 15-year Follow-Up

Human Papillomavirus Infection and the Risk of Erectile Dysfunction: A Nationwide Population-Based Matched Cohort Study

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