Human Papillomavirus Infection and the Risk of Erectile Dysfunction: A Nationwide Population-Based Matched Cohort Study

Juang, Sin-Ei; Sheng‐Kai, Kevin; Kao, Pei-En; Wei, James Cheng‐Chung; Yip, Hei-Tung; Chou, Mei‐Chia; Hung, Yao-Min; Chin, Ning-Chien

doi:10.3390/jpm12050699

Cited by 14 publications

(7 citation statements)

References 80 publications

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“…The bivalent vaccine protects against HPV type 16 and 18 and young women before sexual debut are recommended to be vaccinated. The quadrivalent vaccine targets HPV type 6, 11, 16, and 18 ( 10 ), and both genders are recommended to be vaccinated ( 11 , 12 ). Taiwan government supports HPV vaccination, but less than 4% of female population has been vaccinated ( 12 ).…”

Section: Introductionmentioning

confidence: 99%

Risk of primary Sjogren’s Syndrome following human papillomavirus infections: a nationwide population-based cohort study

Chen

Dong

Chang³

et al. 2022

Front. Immunol.

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IntroductionViral infection is an exogeneous factor for primary Sjogren’s syndrome (pSS). This study investigated the association between human papillomavirus (HPV) infections and pSS through a nationwide population based cohort study.MethodsPatients with HPV infections between January, 1999 and December, 2013 were included. The incidence of new-onset pSS in patients with HPV infections and non-HPV controls were derived. The multiple Cox regression model derived the risk of pSS in patients with HPV infections. Subgroup analysis and sensitivity analysis were performed to validate the association.ResultsDuring a follow-up period of 12 years, the adjusted hazard ratio (aHR) of pSS in patients with HPV infections was significantly higher than that in non-HPV controls (aHR=1.64, 95% CI=1.47-1.83, P<0.001). The risk of pSS increased with age and the risk increased by 2.64-fold (95% CI= 2.37-2.93) for those older than 45 years. The significant association between HPV infections and the risk of pSS persisted in the sensitivity analysis restricted in HPV infections that lasted over 12 months (aHR=1.63, 95%CI=1.45-1.83, P<0.0001). Subgroup analyses revealed that both male (aHR=1.83, 95%CI=1.47-2.28, P<0.0001) and female (aHR=1.58, 95%CI=1.40-1.79, P<0.0001) patients with HPV infections and HPV-infected patients aged between 16 and 45 years (aHR=1.60, 95%CI=1.34-1.91, P<0.0001) and over 45 years (aHR=1.67, 95%CI=1.46-1.91, P<0.0001) were associated with a significantly greater risk of pSS.ConclusionPatients with HPV infections presented with a significantly higher risk of pSS, regardless of age and sex.

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Section: Introductionmentioning

confidence: 99%

Risk of primary Sjogren’s Syndrome following human papillomavirus infections: a nationwide population-based cohort study

Chen

Dong

Chang³

et al. 2022

Front. Immunol.

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“…Despite these potential limitations, in relation to the previous studies, which were mainly cross-sectional, our major strengths include a fairly large sample size in a real-world setting ( 58 , 59 ). Also, propensity score matching was adopted in this longitudinal study to minimize the effect of potential confounding factors ( 60 ) on associations.…”

Section: Discussionmentioning

confidence: 99%

Bidirectional Relationship Between Osteoarthritis and Periodontitis: A Population-Based Cohort Study Over a 15-year Follow-Up

et al. 2022

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ObjectiveTo identify the relationship between osteoarthritis and periodontitis.Methods144,788 periodontitis patients and 144,788 propensity score-matched controls without history of periodontitis were enrolled in this cohort study. A Cox proportional hazard model was used to estimate the risk of osteoarthritis. Survival analysis was utilized to assess the time-dependent effect of periodontitis on osteoarthritis. Age and gender were stratified to identify subgroups at risk. A symmetrical case-control analysis was designed to determine the relationship between present periodontitis and history of osteoarthritis.ResultsPatients with periodontitis had higher risk of osteoarthritis (hazard ratio, HR =1.15, 95% CI =1.12–1.17, p < 0.001) and severe osteoarthritis that led to total knee replacement or total hip replacement (TKR/THR) (HR =1.12, 95% CI =1.03–1.21, p < 0.01) than controls, which was time-dependent (log-rank test p < 0.01). The effect of periodontitis on osteoarthritis was significant in both genders and age subgroups over 30 years-old (all p < 0.001). Among them, females (HR=1.27, 95% CI = 1.13–1.42, p < 0.001) and patients aged over 51 (HR= 1.21, 95% CI =1.10-1.33, p < 0.001) with periodontitis were predisposed to severe osteoarthritis. In addition, periodontitis patients were more likely to have a history of osteoarthritis (odds ratio = 1.11, 95% CI = 1.06 - 1.17, p < 0.001).ConclusionsThese findings suggest an association between periodontitis and a higher risk of osteoarthritis, including severe osteoarthritis that led to TKR/THR. Likewise, periodontitis is more likely to develop following osteoarthritis. A bidirectional relationship between osteoarthritis and periodontitis was observed.

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“…We identified individuals diagnosed with HPV infection (ICD‐9 codes 079.4, 078.1, 078.10–78.12, 078.19, 795.05, 795.09, 795.15, 795.19, 796.75, and 796.79) 17‐20 between January 1, 2008 and December 31, 2015. Figure 1 displays the flowchart for newborns with and without maternal HPV infection.…”

Section: Methodsmentioning

confidence: 99%

Maternal human papillomavirus infection and the risk of congenital malformations: A nationwide population‐based cohort study

Hsieh,

Chen,

Liao

et al. 2024

Journal of Medical Virology

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Previous research has explored theories regarding the vertical transmission of human papillomavirus (HPV) infection and its association with adverse pregnancy and perinatal outcomes. However, the impact of maternal HPV infection on congenital anomalies (CAs) in offspring remains relatively understudied. We conducted a population‐based cohort study linking the Taiwan Birth Registry, Taiwan Death Registry, and National Health Insurance Research Database, in which newborns born in Taiwan between 2009 and 2015 were included. We established a maternal HPV infection cohort comprising 37 807 newborns and matched them with a comparison group of 151 228 newborns at a 1:4 ratio based on index year, age, and sex. The study examined a composite outcome and subgroups of different types of congenital malformations. Differences in cumulative incidence of CAs were assessed using Kaplan–Meier curves and log‐rank tests. Adjusted hazard ratios (aHRs) were estimated using Cox proportional hazard regressions. No significant association was found between HPV infection and the broad spectrum of CAs (aHR: 1.04, 95% confidence interval [CI]: 0.98–1.10; log‐rank test p = 0.14). However, we observed a 19% increased risk of musculoskeletal CAs in the maternal HPV infection group (aHR: 1.19; 95% CI: 1.05–1.34) compared to those without maternal HPV exposure. Other factors, including the type of HPV (aHR: 0.65; 95% CI: 0.16–2.63), the timing of exposure (during or before pregnancy), and maternal age (aHR for <30 years: 1.02, 95% CI: 0.94–1.1; aHR for 30–39 years: 1.05, 95% CI: 0.99–1.11; aHR for ≥40 years: 0.88, 95% CI: 0.67–1.17), did not significantly affect the risk for any CA. In conclusion, gestation detection of HPV infection was associated with musculoskeletal CAs but not other major CAs. Prospective studies are warranted to elucidate the necessity of prenatal screening in populations at risk.

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Human Papillomavirus Infection and the Risk of Erectile Dysfunction: A Nationwide Population-Based Matched Cohort Study

Cited by 14 publications

References 80 publications

Risk of primary Sjogren’s Syndrome following human papillomavirus infections: a nationwide population-based cohort study

Risk of primary Sjogren’s Syndrome following human papillomavirus infections: a nationwide population-based cohort study

Bidirectional Relationship Between Osteoarthritis and Periodontitis: A Population-Based Cohort Study Over a 15-year Follow-Up

Maternal human papillomavirus infection and the risk of congenital malformations: A nationwide population‐based cohort study

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