Fibrohistiocitoma maligno "inflamatorio" de cordón espermático con infiltración sobre un leiomioma inguinal: Presentación de 1 caso con revisión conceptual y de la literatura

Liso, Juan Manuel Ruiz; García, Juan Ruiz; López, M.L.; Vinagre, A. Vaillo; Martín, Antonia Gutiérrez; Martínez, María Cruz Marrón; Pérez, María Ascensión García

doi:10.4321/s0004-06142008000400004

Cited by 2 publications

(3 citation statements)

References 52 publications

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“…However, due to its mesenchymal origin, it is known that this neoplasm can virtually affect any organ [20, 21]. The previous statement correlates with some of the cases described in which IMFH with/without LR has been detected in solid organs, intestinal tract, musculoskeletal tissue, and the integument [12, 14, 17, 19, 22, 23]. …”

Section: Discussionmentioning

confidence: 57%

“…A few reports have documented a normalization of the WBC count after removal of the primary neoplasm, and an increase to previous values or higher once the tumor relapses [12–17]. This finding suggests that IMFH is capable of releasing a variety of cytokines and growth factors which could contribute to the development of the LR/leukocytosis associated with it [9, 10, 12, 15, 16, 18, 19]. …”

Section: Introductionmentioning

confidence: 93%

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Inflammatory Malignant Fibrous Histiocytoma Associated with Leukemoid Reaction or Leukocytosis: A Comprehensive Review

et al. 2012

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Inflammatory malignant fibrous histiocytoma (IMFH) associated with leukemoid reaction (LR)/leukocytosis is a rare entity. In this paper, we search PubMed for all known cases of IMFH associated with LR/leukocytosis in an attempt to draw conclusions about this variant's response to treatments and its pathophysiology. Medline electronic database was searched using key words such as malignant fibrous histiocytoma, leukemoid reaction, and leukocytosis. A total of 16 patients were found, twelve males (75%) and 4 female (25%), with a mean age of 62.6 years, ranging from 47 to 77. The mean survival was 770 days, ranging from 14 to 6570 days. Four patients were alive at last follow-up: 6570 days, 1095 days, 335 days, and 180 days, respectively. Of the 12 patients that expired, death occurred approximately 92 days after the onset of LR or leukocytosis, ranging from 3 to 334 days. We conclude that IMFH associated with LR/leukocytosis does not completely respond to chemoradiation. Overproduction of growth factors and cytokines by IMFH cells and their interactions with the inflammatory infiltrate seem to promote immunological effector cell's dysfunction and substantiate the development and growth of this neoplasm. A clear understanding of these molecular pathways is crucial in order to identify targets for potential therapy.

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Section: Discussionmentioning

confidence: 57%

Section: Introductionmentioning

confidence: 93%

Inflammatory Malignant Fibrous Histiocytoma Associated with Leukemoid Reaction or Leukocytosis: A Comprehensive Review

et al. 2012

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“…The inflammatory type shows tumor cells with neutrophils permeating the tissue ( 43 ). Immunohistochemistry for MFH is positive for CD68 and vimentin and negative for cytokeratin and desmin with certain variations between cases ( 40 - 42 , 44 , 45 ). These tumors have a high chance of reoccurrence in the same area and/or metastasis ( 41 , 42 , 46 ).…”

Section: Malignant Neoplasmsmentioning

confidence: 99%

Neoplastic diseases of the spermatic cord: an overview of pathological features, evaluation, and management

Dagur¹,

Gandhi²,

Kapadia³

et al. 2017

Transl. Androl. Urol.

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Extracellular tumors found with the spermatic cord, known as neoplasms, are usually identified to be benign. However, the accurate and timely diagnosis of spermatic cord masses is highly crucial, especially when most results are often overlooked or unclear. In this review, we discuss the anatomy and embryology of the spermatic cord. Upon rooting these fundamental concepts, we discuss an array of benign and malignant neoplastic tumors, including their origin, pathological features, clinical evaluation and management, as well as other case-specific characteristics of unique presentation. Many of these neoplasms are based on local neurological, vascular, muscular, bone, soft tissue, or lymphatic origin, while others have metastasized from particular areas of the body.

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Fibrohistiocitoma maligno "inflamatorio" de cordón espermático con infiltración sobre un leiomioma inguinal: Presentación de 1 caso con revisión conceptual y de la literatura

Abstract: Resumen.-OBJETIVO: Estudiar los fibrohistiocitomas malignos (FHM) paratesticulares desde el punto de vista clínico-histológico, inmunohistoquímico y su histogéne-sis. MÉTODOS: A través de Medline y búsqueda no in

Cited by 2 publications

References 52 publications

Inflammatory Malignant Fibrous Histiocytoma Associated with Leukemoid Reaction or Leukocytosis: A Comprehensive Review

Inflammatory Malignant Fibrous Histiocytoma Associated with Leukemoid Reaction or Leukocytosis: A Comprehensive Review

Neoplastic diseases of the spermatic cord: an overview of pathological features, evaluation, and management

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