Fibroblastic Overgrowth of Persistent Tunica Vasculosa Lentis in Infants Born Prematurely*

Terry, T. L.

doi:10.1016/s0002-9394(42)91858-0

Cited by 120 publications

(66 citation statements)

References 5 publications

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“…Thus, the extent of the immaturity of the retina depends mainly on the degree of the prematurity at birth. ROP was first noted in the late 1940s in preterm infants and described as retrolental fibroplasia (Terry 1942). At the present time, we now think this initial description may have represented stage 5 ROP, which is the most advanced stage of ROP and characterized by total retinal detachment.…”

Section: Introductionmentioning

confidence: 65%

Low Incidence of Sight-Threatening Retinopathy of Prematurity in Infants Born Before 28 Weeks Gestation at a Neonatal Intensive Care Unit in Japan

Aikawa

Noro

2013

Tohoku J. Exp. Med.

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Improvement in neonatal care has led to increased survival rates of very premature infants. Accordingly, there are now more extremely preterm infants who are at risk of developing retinopathy of prematurity (ROP). ROP is a disorder of low birth-weight preterm infants and may lead to blindness. However, the prevalence of ROP varies globally, depending on different neonatal and ophthalmic care. Therefore, we studied the incidence and progression of ROP in extremely preterm infants in Japan. In addition, we investigated the characteristics and the clinical courses of the infants who progressed to sight-threatening ROP. A total of 3,154 infants were born at the Japanese Red Cross Sendai Hospital between 2009 and 2011, including 53 live-born infants born before 28 weeks' gestation. Two extremely preterm infants died before the first ROP examination. Among the survived 51 infants (the birth-weight ranged from 309 to 1,354 g, mean 779 g), 36 infants (70.6%) developed ROP: 18 infants with mild ROP and 18 infants with severe ROP. Eight out of the 51 infants (15.7%) underwent laser treatment. None of the infants born at older than 27 weeks 0 day of gestation required any treatment for ROP. In conclusion, most of extremely preterm infants develop some degree of ROP. However, in the majority of these infants the ROP never progressed beyond mild disease and resolved spontaneously without treatment. Sight-threatening ROP was rare. The present study clarifies the natural history of ROP in extremely preterm infants with active perinatal care.

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Section: Introductionmentioning

confidence: 65%

Low Incidence of Sight-Threatening Retinopathy of Prematurity in Infants Born Before 28 Weeks Gestation at a Neonatal Intensive Care Unit in Japan

Aikawa

Noro

2013

Tohoku J. Exp. Med.

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“…1 Another example is necrotizing enterocolitis, related to intestinal immaturity. 2,3 Other entities of a more chronic character, such as bronchopulmonary dysplasia 4 and retinopathy of prematurity, 5 emerged as a result of the development of aggressive therapies for this special population.…”

Section: Historical Contextmentioning

confidence: 99%

Origens desenvolvimentistas da saúde e da doença (DOHaD)

Silveira¹,

Portella²,

Goldani³

et al. 2007

J. Pediatr. (Rio J.)

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Objective: To present a new branch of scientific knowledge, known as the developmental origins of health and disease (DOHaD), covering its concepts, study methods and ethical considerations in addition to the prospects for this area of knowledge. Sources:A non-systematic review of the biomedical literature intended to identify historical and current references related to the subject under discussion.

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“…Outro exemplo é a enterocolite necrosante, relacionada à imaturidade intestinal 2,3 . Ainda outras entidades de caráter mais crônico, como a displasia broncopulmonar 4 e a retinopatia da prematuridade 5 Nos anos 1960, Neel lançou a "hipótese do genótipo poupador" 8 , propondo que determinadas populações apresentavam maior propensão à resistência insulínica, tanto por seleção quanto por aspectos genéticos. Segundo esse autor, uma mutação aleatória levando à resistência à insulina poderia ser adaptativa e benéfica para indivíduos expostos a ambientes com escassez alimentar, originando seleção natural desses indivíduos, com a conseqüente transmissão do caráter para as gerações seguintes.…”

Section: Contexto Históricounclassified

Developmental Origins of Health and Disease (DOHaD)

2006

Early Human Development

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ResumoObjetivo: Apresentar um novo ramo da ciência, denominado origens desenvolvimentistas da saúde e doença (DOHaD), abordando conceitos, métodos de estudo, aspectos éticos e perspectivas para essa área do conhecimento. Fontes dos dados:Revisão não sistemática da literatura biomédica, com o intuito de obter referências históricas e atualizadas relacionadas com o tema em discussão. Síntese dos dados:Estudos recentes demonstram associações entre agravos ocorridos em fases iniciais do desenvolvimento somático e a amplificação do risco para doenças crônicas ao longo da vida, tais como obesidade, diabetes e doenças cardiovasculares. Diferentes modelos foram propostos na tentativa de melhor explicar essas associações, como a teoria do fenótipo poupador, a programação, as respostas adaptativas preditivas e o conceito de concordância ou contraste. Alguns dos possíveis mecanismos envolvidos nesses processos são: efeitos do ambiente sobre a expressão gênica, através de mecanismos epigenéticos; efeitos de sinais hormonais transmitidos ao feto através da placenta ou ao recém-nascido através da lactação. Conclusões:O DOHaD agrega informações advindas de várias áreas do conhecimento, propondo novas metodologias de investigação no sentido de esclarecer a influência de eventos adversos ocorridos em fases precoces do desenvolvimento humano sobre o padrão de saúde e doença ao longo da vida. Esse novo campo da ciência propõe novos modelos de causalidade e mecanismos envolvidos no surgimento e desenvolvimento de doenças crônicas. Os resultados dessas investigações poderão resultar em impacto significativo na prevenção de doenças crônicas, bem como na promoção de saúde em diferentes fases da vida.J Pediatr (Rio J). 2007;83(6):494-504: DOHaD, programação, hipótese de Barker. AbstractObjective: To present a new branch of scientific knowledge, known as the developmental origins of health and disease (DOHaD), covering its concepts, study methods and ethical considerations in addition to the prospects for this area of knowledge. Sources:A non-systematic review of the biomedical literature intended to identify historical and current references related to the subject under discussion. Summary of the findings:Recent studies demonstrate associations between aggressions suffered during the initial phases of somatic development and amplified risk of chronic diseases throughout life, such as obesity, diabetes and cardiovascular diseases. A variety of models have been proposed in attempts to better explain these associations, such as the thrifty phenotype, programming and predictive adaptive response theories and the concept of match or mismatch. Some of the mechanisms possibly involved in these processes are: effects of the environment on gene expression, through epigenetic mechanisms; effects of hormonal signals transmitted to the fetus via the placenta or the newborn via lactation.Conclusions: DOHaD draws together information originating from many different areas of knowledge, proposing new investigative methodologies to elucidate the influe...

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Fibroblastic Overgrowth of Persistent Tunica Vasculosa Lentis in Infants Born Prematurely*

Cited by 120 publications

References 5 publications

Low Incidence of Sight-Threatening Retinopathy of Prematurity in Infants Born Before 28 Weeks Gestation at a Neonatal Intensive Care Unit in Japan

Low Incidence of Sight-Threatening Retinopathy of Prematurity in Infants Born Before 28 Weeks Gestation at a Neonatal Intensive Care Unit in Japan

Origens desenvolvimentistas da saúde e da doença (DOHaD)

Developmental Origins of Health and Disease (DOHaD)

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