Fibro-porous PLLA/gelatin composite membrane doped with cerium oxide nanoparticles as bioactive scaffolds for future angiogenesis

Abstract

Functionalized cerium oxide nanoparticles (CeNPs) loaded fibro-porous Poly-L-Lactic acid (PLLA)/Gelatin composite membranes were prepared via electrospinning technology. Considering the importance of such membrane scaffolds for promoting angiogenesis in tissue engineering...

Cerium oxide nanoparticles loaded nanofibrous membranes promote bone regeneration for periodontal tissue engineering

“…5 ), which is important for further regenerative studies. As CeO 2 NPs used in our work were small, there was no obvious morphological change of fibers loaded with NPs, while the mechanical properties had been improved in PG-CeO 2 , as well as in PLLA/gelatin composite membrane doped with CeNP [ 56 ] and MgO [ 57 ]. The anti-oxidative activities of CeO 2 are essential in its biomedical application.…”

PLLA–gelatin composite fiber membranes incorporated with functionalized CeNPs as a sustainable wound dressing substitute promoting skin regeneration and scar remodeling

“…After the reaction, they were centrifuged, dried and ground in a vacuum to obtain CeNPs. 15,[63][64][65] The silane functionalized CeNPs were characterized using transmission electron microscopy (TEM) and high-resolution TEM (HR-TEM). The TEM and HR-TEM measurements were carried out using an FEI Titan 80 at 300 kV.…”

“…67,68 Briefly, 50 mM EDC and 20 mM NHS are dissolved in 100 mL mixed solvent of ethanol and DI water (9 : 1, V/V), and then the dried fiber membranes were crosslinked for 12 h at room temperature (RT). 15,68 The details of the cross-linking process parameters are summarized in Table S2 (ESI †). The crosslinked membranes were washed with DI water to remove the excess by-products from the crosslinking reaction as well as additional unreacted cross-linking reagents.…”

“…13 Recently, PLLA in combination with other natural polymers has been used as a promising wound dressing matrix. [14][15][16][17] Water absorption and bacteriostasis of wound dressings play an important role in wound recovery and healing. 18 To improve the hydrophilicity of the PLLA micro and nanofiber membranous matrices, FDA approved natural polymers such as gelatin, collagen and chitosan have widely been used to blend for the preparation of composite matrices.…”

“…57 Electrospun fibers of micro and nanometer size fabricated from various natural, synthetic and composite polymers have been used in tissue engineering and regenerative medicine. 15,58 These micro and nanofiber matrices can be fabricated using wellestablished sustainable electrospinning technology. [59][60][61][62] The use of drugs, growth factors, and nanomedicine as bioactive additives could have a significant impact on the overall composite matrix towards better tissue regeneration and wound healing.…”