Fibrinolytic Gene Polymorphism and Ischemic Stroke

Jood, Katarina; Ladenvall, Per; Tjärnlund-Wolf, Anna; Ladenvall, Claes; Andersson, Maria; Nilsson, Staffan; Blomstrand, Christian; Jern, Christina

doi:10.1161/01.str.0000183617.54752.69

Cited by 82 publications

(65 citation statements)

References 35 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Several studies have investigated the regulating role of t-PA in the degradation of the thrombus and founded that the protein appears to activate the transformation of plasminogen to plasmin, which digests the fibrin clot [14,15]. The I/D polymorphism in the gene coding for t-PA was associated with an increased or decreased levels in serum t-PA. Further, the homozygous genotype I/I of the t-PA gene was associated with a higher risk of MI [16]. In this study, we found no significant differences between the two groups in terms of allelic and genotypic frequencies.…”

Section: Discussioncontrasting

confidence: 51%

Alu-repeat Polymorphism in the Tissue Plasminogen Activator Gene and Risks of Myocardial Infarction in Tunisian Population

Bahri¹

2016

Med chem

View full text Add to dashboard Cite

This study aimed to determine whether I/D polymorphism predispose to the development of MI in Tunisia. 50 patients with coronary artery disease complicated by MI and 70 healthy controls were analyzed. Quantitative analyses lipids are founded. DNA was isolated from blood samples. Polymorphisms were assessed by polymerase chain reaction method. Statistical differences between groups were determined by Chi-square test. Compared to controls, cases have significantly higher levels of total cholesterol, triglycerides and LDL-cholesterol and lower level of HDL-cholesterol. There are no significant differences between patients and controls in terms of allelic and genotypic frequencies. However, the frequency of the "I" allele is higher in cases which have 2 MI (p=0.0354). Additionally, a statistically significant association between diabetes, arterial high blood pressure, family history and cigarette smoking with MI was founded (p<0.01). I/D polymorphism of t-PA gene is not associated with MI in this sample of Tunisian population.

show abstract

Section: Discussioncontrasting

confidence: 51%

Alu-repeat Polymorphism in the Tissue Plasminogen Activator Gene and Risks of Myocardial Infarction in Tunisian Population

Bahri¹

2016

Med chem

View full text Add to dashboard Cite

show abstract

“…The intra-and inter-assay coefficients of variation were 5.3% and 13.3%, respectively. The serum levels of high-sensitivity C-reactive protein (hsCRP) were analyzed in a solid-phase chemiluminescent immunometric assay, the plasma levels of tissue type plasminogen activator (t-PA) antigen were analyzed by ELISA and plasma fibrinogen was measured with an automated clot rate assay, as described previously [20][21][22].…”

Section: Blood Sampling and Vwf Measurementmentioning

confidence: 99%

“…The number of individuals for whom the values for risk factors and other covariates were missing, have been reported previously [19][20][21][22]. In the logistic regression, missing values were replaced by dummy variables for the covariates being categorical variables.…”

Section: Missing Datamentioning

confidence: 99%

See 1 more Smart Citation

Plasma levels of von Willebrand factor in the etiologic subtypes of ischemic stroke

Hanson

Jood

Karlsson

et al. 2011

Journal of Thrombosis and Haemostasis

View full text Add to dashboard Cite

Summary. Background: Compared with coronary artery disease, there are few studies on von Willebrand factor (VWF) in ischemic stroke (IS). Moreover, there is little information on VWF in the etiologic subtypes of IS. Objectives: The aim of the present study was to investigate VWF in IS and in the etiologic subtypes of IS. Patients/methods: The Sahlgrenska Academy Study on Ischemic Stroke (SAHLSIS) is a case-control study comprising 600 patients and 600 matched controls. Etiologic IS subtype was defined according to the TOAST criteria. Blood sampling was performed in the acute phase and after 3 months. Results: The levels of VWF were increased in overall IS, at both time-points. The 3-month VWF levels were increased in the subtypes of large-vessel disease (LVD), cardioembolic (CE) stroke and cryptogenic stroke, but not in the subtype of smallvessel disease (SVD), as compared with the controls. The acute phase VWF levels were significantly increased in all four subtypes. In the multivariate regression analysis, with vascular risk factors as covariates, the 3-month VWF levels were associated with CE stroke and cryptogenic stroke, and the acute phase VWF levels with all subtypes. There were significant subtype-specific differences in VWF, with the highest levels in LVD and CE stroke. Conclusions: The present results show that VWF levels are increased in patients with IS. Furthermore, the VWF levels differ between etiologic IS subtypes and thus, it is important to consider etiologic subtypes in future studies of VWF in patients with IS.

show abstract

“…Their results show that t-PA -7351 C>T and PAI-1 -675 4G>5G polymorphism affects transcriptional activity and that these two variants are connected to myocardial infarction with an increased risk in the case of T and 5G alleles. However, in the case of cerebral ischemia this connection does not occur, so it assumed that the role of t-PA and PAI-1 is more complex in brain than in heart (30). Contrary to these, other studies consider the plasminogen activator system to be the one which plays the key role in the pathogenesis of cerebral ischemia (31).…”

Section: Discussionmentioning

confidence: 99%

Decrease of Fibrinolytic Potential in the Occurence of Cerebral Ischemia

Vučković¹,

Đerić²,

Ilić³

et al. 2008

Journal of Medical Biochemistry

View full text Add to dashboard Cite

Summary:One of the most present clinical manifestations of long and progressive atherothrombotic occurrences is the ischemic cerebrovascular insult, one of the leading causes of death and illness in the world. Lately, a growing number of scientists believe that disorders in the fibrinolytic mechanism function are the key to the occurrence of cerebral ischemia. The goal of this study is to investigate whether the disorder of the fibrinolytic mechanism has influence on the occurrence of ischemic cerebrovascular insult. Our study includes 90 examinees, 60 of which suffer from ischemic cerebrovascular insult and 30 are clinically healthy examinees forming the control group. The results of our investigation show that statistically a significantly larger number of patients has decreased fibrinolytic potential comparing with controls (p<0.01). According to this, it has been noted that euglobulin lysis clot time in the patient group is significantly longer (p=0.005). Statistically, no significant difference has been noted related to the activity of plasminogen (p=0.085). Further on, the plasminogen activator inhibitor-1 values among the patients have been significantly higher (p=6.20×10 ). The results of this investigation impose the conclusions that the decrease in fibrinolytic potential affects the occurrence of ischemic cerebrovascular insult, that it is directly connected to the higher levels of plasminogen activator inhibitor-1 and that the growth of tissue-type plasminogen activator antigen concentration participates in the decrease of fibrinolytic potential among patients suffering from cerebral ischemia. Keywords: fibrinolytic system, plasminogen, tissue-type plasminogen activator, plasminogen activator inhibitor-1 Kratak sadr`aj: Jedna od naj~e{}ih klini~kih manifestacija dugotrajnih i progresivnih aterotrombotskih zbivanja je ishemijski cerebrovaskularni insult. To oboljenje se danas nalazi me|u vode}im uzrocima morbiditeta i mortaliteta u ve}ini zemalja. U poslednje vreme sve je ve}i broj nau~nika koji smatraju da su poreme}aji fibrinoliznog mehanizma kljuñ astanka cerebralne ishemije. Cilj na{e studije bio je upravo da ispitamo da li poreme}aj fibrinoliznog mehanizma ima uticaja na nastanak ishemijskog cerebrovaskularnog insulta. U studiju je uklju~eno 90 ispitanika, od toga 60 bolesnika koji su do`iveli cerebrovaskularni insult po tipu ishemije i 30 klini~ki zdravih osoba, koje su ~inile kontrolnu grupu. Rezultati na{eg istra`ivanja ukazuju na statisti~ki zna~ajno ve}i broj ispitanika sa suprimiranim fibrinoliznim potencijalom u grupi bolesnika u odnosu na kontrolnu grupu (p<0,01). U skladu s tim, ustanovljeno je statisti~ki zna~ajno du`e euglobulinsko vreme lize koaguluma me|u bolesnicima nego me|u kontrolama (p=0,005). Nije uo~ena statisti~ki zna~ajna razlika u aktivnosti plazminogena izme|u te dve grupe ispitanika (p=0,085), dok su vrednosti inhibitora aktivatora plazminogena-1 (p=6,20×10 -11 ) i antigena tkivnog aktivatora plazminogena (p=5,20×10 -5 ) statisti~ki zna~ajno vi{e u grupi bolesnika. Ov...

show abstract

Fibrinolytic Gene Polymorphism and Ischemic Stroke

Cited by 82 publications

References 35 publications

Alu-repeat Polymorphism in the Tissue Plasminogen Activator Gene and Risks of Myocardial Infarction in Tunisian Population

Alu-repeat Polymorphism in the Tissue Plasminogen Activator Gene and Risks of Myocardial Infarction in Tunisian Population

Plasma levels of von Willebrand factor in the etiologic subtypes of ischemic stroke

Decrease of Fibrinolytic Potential in the Occurence of Cerebral Ischemia

Contact Info

Product

Resources

About