Alu-repeat Polymorphism in the Tissue Plasminogen Activator Gene and Risks of Myocardial Infarction in Tunisian Population

Abstract

This study aimed to determine whether I/D polymorphism predispose to the development of MI in Tunisia. 50 patients with coronary artery disease complicated by MI and 70 healthy controls were analyzed. Quantitative analyses lipids are founded. DNA was isolated from blood samples. Polymorphisms were assessed by polymerase chain reaction method. Statistical differences between groups were determined by Chi-square test. Compared to controls, cases have significantly higher levels of total cholesterol, triglycerides and LDL-cholesterol and lower level of HDL-cholesterol. There are no significant differences between patients and controls in terms of allelic and genotypic frequencies. However, the frequency of the "I" allele is higher in cases which have 2 MI (p=0.0354). Additionally, a statistically significant association between diabetes, arterial high blood pressure, family history and cigarette smoking with MI was founded (p<0.01). I/D polymorphism of t-PA gene is not associated with MI in this sample of Tunisian population.

Alu DNA Polymorphism of Human Tissue Plasminogen Activator (tPA) Gene in Diabetic Jordanian Patients Patients

“…On the other hand, the Alu +/+ genotype was associated with the elevated levels of plasma PAI-1 [ 12 ] . Nonetheless, others did not report such an association [ 28 , 36 , 37 ] .…”

“…Furthermore, the Alu polymorphism has not been found to be involved in tPA production but rather in its release rate [ 15 ] . Though this genotype has been implicated as a risk factor in T2DM and MetS [ 13 ] , an association between the I/D polymorphism and tPA synthesis or plasma levels has not been investigated yet [ 26 - 28 ] . In this study, we intended to address the genotypic and allelic distributions and possible association of the Alu DNA diverseness in the tPA gene within DM Jordanian patients.…”