Fibrinolytic and hypoglycemic effects of the Pro-Gly-Pro-Leu peptide during development of insulin-dependent diabetes in rats

Correction of impairments in functions of anticoagulation and insular systems of an organism by the regulatory peptide Leu-Pro-Gly-Pro

“…Preservation of normal function ing of insular and anticoagulation blood systems dur ing development of alloxan diabetes in rats is provided by the regulatory glyproline peptides Pro⎯Gly⎯Pro, Pro⎯Gly, and Pro⎯Gly⎯Pro⎯Arg (Ashmarin et al, 2008;Lyapina et al, 2010), which are produced in the body by proteolysis of collagen and other proteins related to it (Molinero et al, 2008). Herewith, antico agulant and fibrinolytic activities (Ashmarin et al, 2002;Lyapina et al, 2006) and antiplatelet activity (Pastorova et al, 2003) are increasing in the blood plasma.…”

“…The amino acid, leucine, is known to play a key role in the prevention of diabetes (Balabolkin et al, 2008) by stimulating the production of insulin in the pancreas (Duttaroy et al, 2005). Glyprolines, including Pro⎯Gly⎯Pro⎯Leu, that are used under conditions of development of experimental diabetes mellitus, have shown to have both a prophylactic and a therapeutic hypoglycemic effect (Lyapina et al, 2010;Grigor'ieva et al, 2011;Myasoedov et al, 2011).…”