Fibrinogen-to-Albumin Ratio in Familial Mediterranean Fever:
                    Association with Subclinical Inflammation

Önder, Esra Nagehan Akyol; Ertan, Pelin

doi:10.1055/a-1610-9745

Cited by 6 publications

(2 citation statements)

References 33 publications

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“…Its frequency in the general population in our country has been shown to be approximately 0.1%. [24] Cardiology clinics are one of the clinics where they are first diagnosed because of their frequent recurrent episodes of chest pain. The most important finding in diagnosis is usually recurrent attacks.…”

Section: Discussionmentioning

confidence: 99%

Etiological Evaluation in Children Referred to the Pediatric Cardiology Outpatient Clinic with Chest Pain

Karabulut

2023

Sisli Etfal

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Objectives One of the most common reasons for pediatric cardiology referrals is chest pain in childhood. Although it is mostly innocent in character, it is rarely associated with life-threatening pathologies. In this study, it was aimed to evaluate the etiological causes in children with chest pain. Methods Our study included 1000 children who were referred to the pediatric cardiology clinic with the complaint of chest pain between January 2019 and June 2022. Demographic characteristics, accompanying complaints, echocardiographies, electrocardiographies, 24-h rhythm holters, treadmill exercise test, computed tomography angiography, and non-cardiac findings related to etiology were analyzed retrospectively from the file archives of the patients. Results Five hundred and nine (50.9%) of the patients were female and 491 (49.1%) were male. The mean age of the patients was 11.3 y (range: 3–18 years). Cardiological pathology associated with chest pain was detected in only 6.8% of the patients. Among the etiologies of chest pain, mitral valve prolapse (MVP) was the most common cardiological pathology with a rate of 2.1%. In the non-cardiac etiological evaluation of chest pain, idiopathic causes with a frequency of 48%, musculoskeletal pathologies with a frequency of 22.6%, respiratory pathologies with a frequency of 7.9%, psychiatric pathologies with a frequency of 7.3%, gastrointestinal pathologies with a frequency of 4.1%, and familial Mediterranean fever with a frequency of 2.4%, miscellaneous with a frequency of 1.1% were found, respectively. Conclusion In the study, it was determined that non-cardiac causes were more common among the etiological causes of chest pain in the pediatric age group. In addition, MVP was the most common cause of cardiac chest pain.

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Section: Discussionmentioning

confidence: 99%

Etiological Evaluation in Children Referred to the Pediatric Cardiology Outpatient Clinic with Chest Pain

Karabulut

2023

Sisli Etfal

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“…We also note that albumin-formulated parameters such as albumin-to-fibrinogen ratio and C-reactive protein-to-albumin ratio have emerged as novel biomarkers to predict inflammation. 13–15 Concerning that the total bilirubin/albumin ratio has never been mentioned in other literature related to the inflammation of rheumatoid arthritis, the variable was taken into our study.…”

Section: Introductionmentioning

confidence: 99%

Correlation Between Total Bilirubin, Total Bilirubin/Albumin Ratio with Disease Activity in Patients with Rheumatoid Arthritis

Zhang¹,

Yang²,

Jiang³

et al. 2023

IJGM

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Purpose Rheumatoid arthritis (RA) is a systemic inflammatory disorder with unknown etiology. Oxidative stress and immune imbalance play a critical role in the pathogenesis of rheumatoid arthritis. Bilirubin has recently been recognized as a potent antioxidant as well as an immunomodulatory agent of physiological importance. The aim of this study was to explore whether increased bilirubin concentrations are correlated with good clinical prognosis of rheumatoid arthritis. Patients and Methods In this cross-sectional study, we included 197 healthy individuals and 197 RA patients in the Affiliated Hospital of North Sichuan Medical College from October 2020 to February 2022. The latter were classified into three classes of disease activity according to DAS28-ESR: remission and low (DAS28-ESR<3.2), moderate (3.2≤DAS28-ESR≤5.1), and high (DAS28ESR>5.1). Based on the clinical and laboratory data, we evaluated the association of bilirubin levels with disease activity in RA using multivariable ordered logistic regression. Results The levels of total bilirubin and total bilirubin/albumin ratio were significantly lower (P < 0.001; P < 0.001) in RA patients compared with healthy controls. In RA patients, Spearman’s rank correlation analysis revealed that bilirubin and total bilirubin/albumin ratio were negatively correlated with disease activity and inflammatory marker (C-reactive protein, erythrocyte sedimentation rate, Interleukin-6). In multivariable ordered logistic regression, higher total bilirubin (OR=0.77, 95% CI: 0.67–0.89, p <0.001) independently predicted lower disease activity. Conclusion Bilirubin levels remain associated with a reduction of disease activity, suggesting that bilirubin may be a protective factor for RA aggravation.

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Fibrinogen-to-albumin ratios are related to mortality in patients with secondary malignant neoplasm of bone and bone marrow

Zhong

2023

Heliyon

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Fibrinogen-to-Albumin Ratio in Familial Mediterranean Fever: Association with Subclinical Inflammation

Cited by 6 publications

References 33 publications

Etiological Evaluation in Children Referred to the Pediatric Cardiology Outpatient Clinic with Chest Pain

Etiological Evaluation in Children Referred to the Pediatric Cardiology Outpatient Clinic with Chest Pain

Correlation Between Total Bilirubin, Total Bilirubin/Albumin Ratio with Disease Activity in Patients with Rheumatoid Arthritis

Fibrinogen-to-albumin ratios are related to mortality in patients with secondary malignant neoplasm of bone and bone marrow

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