Fibrinogen/Albumin Ratio as a Promising Marker for Predicting Survival in Pancreatic Neuroendocrine Neoplasms

Deng, Shengming; Fan, Zhichao; Xia, Huanyu; Gong, Yitao; Qian, Yunzhen; Huang, Qiuyi; He, Cheng; Jin, Kaizhou; Xiao, Zhiwen; Luo, Guopei; Lei, Yu; Liu, Chen

doi:10.2147/cmar.s275173

Cited by 10 publications

(10 citation statements)

References 37 publications

(39 reference statements)

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“…In our study, low AFR was significantly associated with old age, high level of Glb, low level of CHOL, LDL and Hb, suggesting low AFR was accompanied by complicated malnutrition and metabolic dysfunction, which could further contribute to poor prognosis 27 . Moreover, our results suggested that the lower the AFR level, the more malignant of pathology and worse clinical outcomes, which are supported by previous studies in pancreatic cancer, ovarian cancer and gastrointestinal cancer 13 , 28 , 29 .…”

Section: Discussionsupporting

confidence: 89%

Prognostic Value of Preoperative Albumin-to-Fibrinogen Ratio in Patients with Bladder Cancer

Zhang

Zeng

et al. 2021

J. Cancer

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Background: Both nutritional status and coagulation function are closely associated with prognosis in patients with bladder cancer (BC). This study aimed to investigate the prognostic value of albumin-to-fibrinogen ratio (AFR) for BC patients underwent radical cystectomy (RC) or transurethral resection of bladder tumor (TURBT), and develop predictive nomograms based on AFR. Methods: We retrospectively collected medical records of 358 BC patients who underwent RC or TURBT between January 2012 and December 2018. The whole cohort was divided into the training (215 patients, 60.06%) and validation cohorts (143 patients, 39.94%) based on surgery dates. The training cohort was applied to select characteristics and construct nomograms, while the validation cohort was used to verify the nomograms independently. Endpoints of the current study included overall survival (OS), disease-specific survival (DSS) and disease-free survival (DFS). Prognostic values of AFR and other characteristics were evaluated using univariate and multivariate Cox regression analyses and compared using the concordance-index (C-index). Nomograms for OS, DSS and DFS were constructed based on both-directional stepwise Cox proportional hazards regression analysis and evaluated by the receiver operating characteristic (ROC) curve, the C-index and calibration plot. Results: In whole cohort, 86 patients (24.02%) were classified into low AFR group and had worse OS (hazard ratio [HR]: 4.079, 95% confidence interval [CI]: 2.085-7.982, P < 0.001), DSS (HR: 3.012, 95% CI: 1.302-6.966, P = 0.010) and DFS (HR: 1.863, 95% CI: 1.204-2.883, P = 0.005) compared to BC patients in high AFR group. Meanwhile, the AFR processed better prognostic power than albumin and fibrinogen, individually. Multivariate Cox analysis indicated that AFR was an independent prognostic factor for OS (HR: 2.601, 95% CI: 1.057-6.395, P = 0.037) and DFS (HR: 1.971, 95% CI: 1.049-3.703, P = 0.035). Novel nomograms, incorporating AFR, tumor grade and tumor multifocality, were constructed and successfully validated for predictions of OS, DSS and DFS in BC. Conclusions: Preoperative AFR was identified as an independent prognostic predictor for OS and DFS of BC patients underwent surgery. The nomograms incorporating AFR provided accurate predictions for OS, DSS and DFS, which could help urologists in better clinical decision-making.

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Section: Discussionsupporting

confidence: 89%

Prognostic Value of Preoperative Albumin-to-Fibrinogen Ratio in Patients with Bladder Cancer

Zhang

Zeng

et al. 2021

J. Cancer

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“…In recent years, there have been continuous studies to explore the relationship between FAR and the clinical outcome of human solid tumors ( 29 , 35 , 36 , 39 ). FAR is expected to be a simple, inexpensive, and readily available biomarker for predicting clinical prognosis in patients with solid tumors.…”

Section: Discussionmentioning

confidence: 99%

The prognostic value of fibrinogen to albumin ratio in malignant tumor patients: A meta-analysis

Deng

Lei

et al. 2022

Front. Oncol.

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BackgroundRecent studies have shown that the fibrinogen to albumin ratio (FAR) is closely related to the prognosis of various cancers. The aim of this systematic review and meta-analysis was to investigate the prognostic value of FAR in malignancies based on the available evidence.MethodTo systematically search the Cochrane Library, Embase, PubMed, Google Scholar, Baidu scholars, CNKI and VIP databases for relevant studies published before April 1, 2022, and to evaluate the fibrinogen-to-albumin ratio (FAR) and survival of patients with malignant tumors through a meta-analysis relationship between the results. Results. This meta-analysis included 19 eligible studies involving 5926 cancer patients. We found that high FAR was associated with poor overall survival (HR=2.25, 95%CI 1.86-2.74, p<0.001), recurrence-free survival (HR=2.29, 95%CI 1.91-2.76, P<0.001), progression-free survival (HR: 2.10, 95%CI 1.58-2.79, p<0.001), disease-free survival (HR=1.52, 95%CI 1.17-1.96, p=0.001), and time to recurrence (HR: 1.555, 95%CI 1.031-2.346, P=0.035) was significantly correlated.ConclusionsHigh FAR is significantly associated with poor clinical outcomes in cancer, suggesting that it may be an important predictor of prognosis in patients with malignancies.

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“…Based on the receiver operating characteristic (ROC) curve, the maximum value of the Youden index (sensitivity + specificity −1) was performed to obtain the optimal cut-off values of FAR, PLR, and NLR. 24 And the cut-off values of AFP and CA19-9 were referred to the previous literature. 23 All categorical variables were expressed by numbers and percentages.…”

Section: Methodsmentioning

confidence: 99%

The Fibrinogen/Albumin Ratio Index as an Independent Prognostic Biomarker for Patients with Combined Hepatocellular Cholangiocarcinoma After Surgery

Xu¹,

Li²,

Ye³

et al. 2022

CMAR

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Purpose The fibrinogen/albumin ratio (FAR) is increasingly considered as a potential biomarker for predicting prognosis in various malignant tumors, whereas the value of the FAR in predicting the recurrence-free survival (RFS) in patients with combined hepatocellular cholangiocarcinoma (cHCC-CCA) after surgery has not been studied. Patients and Methods A total of 104 patients with surgical-pathologically proved cHCC-CCA were retrospectively analyzed. The best cut-off value of the FAR was calculated via receiver operating characteristic (ROC) curve analysis, and the cohort was then divided into two groups as high-FAR (H-FAR) group and low-FAR (L-FAR) group. The correlation between the preoperative FAR and clinicopathological characteristics was analyzed. Uni- and multi-variable analyses for RFS were evaluated using a Cox proportional hazards model to verify the predictive value of FAR on the RFS of cHCC-CCA. Additionally, a novel clinical nomogram based on FAR was developed to preoperatively predict the RFS of HCC-CCA. The C-index and calibration were conducted to evaluate the performance of the developed nomogram. Results According to the cut-off value of the FAR, the patients were grouped into the H-FARI (>0.075) and L-FARI (≤0.075) groups. FAR was significantly correlated with several clinical-pathological features, including age, cirrhosis, AFP, CA19-9, BCLC staging, NLR, and PLR. In the multi-variate analysis, FAR, cirrhosis and tumor size were independent prognostic predictors for poor RFS in cHCC-CCA patients after surgery. Moreover, the clinical nomogram based on FAR was constructed, showing well-predictive accuracy. Conclusion The preoperative FAR is a convenient and feasible serum biomarker for predicting the RFS of cHCC-CCA after surgery. Such developed FAR-based nomogram integrating tumor size and cirrhosis could be served as a feasible and convenient tool to assist the decision-making of clinical strategy.

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Fibrinogen/Albumin Ratio as a Promising Marker for Predicting Survival in Pancreatic Neuroendocrine Neoplasms

Cited by 10 publications

References 37 publications

Prognostic Value of Preoperative Albumin-to-Fibrinogen Ratio in Patients with Bladder Cancer

Prognostic Value of Preoperative Albumin-to-Fibrinogen Ratio in Patients with Bladder Cancer

The prognostic value of fibrinogen to albumin ratio in malignant tumor patients: A meta-analysis

The Fibrinogen/Albumin Ratio Index as an Independent Prognostic Biomarker for Patients with Combined Hepatocellular Cholangiocarcinoma After Surgery

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