The Fibrinogen/Albumin Ratio Index as an Independent Prognostic Biomarker for Patients with Combined Hepatocellular Cholangiocarcinoma After Surgery

Xu, Jiake; Li, Shaochun; Ye, Feng; Zhang, Jie; Peng, Youduo; Wang, Xiaohong; Wang, Hongwei

doi:10.2147/cmar.s361462

Cited by 6 publications

(6 citation statements)

References 33 publications

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“…The fibrinogen-to-albumin ratio (FAR) is increasingly considered a potential biomarker for predicting prognosis in various diseases [ 43 ]. In a study by Cicekli et al, it was reported that FAR levels might be useful in predicting mortality risk in COVID-19 patients [ 44 ].…”

Section: Discussionmentioning

confidence: 99%

FAR Ratio as Prognostic Biomarker in AMI

Muhtaroğlu

Çapoğlu

Uygur

et al. 2023

SN Compr. Clin. Med.

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Acute mesenteric ischemia (AMI) is a vascular emergency resulting from decreased blood flow caused by the occlusion of the mesenteric vessels, hypoperfusion, or vasospasm. This study aimed to investigate the prognostic value of the fibrinogen-to-albumin (FAR) ratio in patients with acute mesenteric ischemia. A total of 91 patients were enrolled in the study. Patients’ demographics such as age and gender, pre- and postoperative hemoglobin, CRP, white blood cell (WBC), neutrophils, preoperative lymphocyte, alanine transaminase (ALT), aspartate transaminase (AST), thrombocytes, and postoperative D-dimer values were recorded. In addition, pre- and postoperative fibrinogen and albumin levels were recorded, and FAR was calculated. Patients were divided into two groups, survivors and non-survivors. The mean pre- and postoperative fibrinogen levels were statistically significantly higher in the non-survivor group than in the survivor group ( p < 0.001). The mean pre- and postoperative albumin levels were significantly lower in the non-survivors than in the survivors ( p = 0.059, p < 0.001; respectively). The mean pre- and postoperative FAR ratios were considerably higher in the non-survivor than in the survivor groups ( p < 0.001). The change between pre- and postoperative fibrinogen, albumin, and FAR values was statistically significant between the non-survivors and the survivors (for all, p < 0.05). The preoperative and postoperative fibrinogen levels were significantly lower, and albumin levels were significantly higher in the survivor compared to the non-survivor patients with AMI. Furthermore, the preoperative and postoperative FAR ratio was significantly higher in the non-survivors. The FAR ratio may be a valuable prognostic biomarker for patients with AMI.

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Section: Discussionmentioning

confidence: 99%

FAR Ratio as Prognostic Biomarker in AMI

Muhtaroğlu

Çapoğlu

Uygur

et al. 2023

SN Compr. Clin. Med.

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“…T2a and T2b were merged into T2, which represented the equivalent effect of tumor multifocality and vascular invasion ( 8 ). A growing number of studies have identified tumor size as an independent prognostic predictor for poor survival outcomes in patients with cHCC-CCA ( 22 , 23 ). Our results in this study reflected the previous findings that patients with tumor size > 5 cm were associated with faster tumor relapse.…”

Section: Discussionmentioning

confidence: 99%

Tumor burden score dictates prognosis of patients with combined hepatocellular cholangiocarcinoma undergoing hepatectomy

et al. 2023

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BackgroundThe prognostic value of the tumor burden score (TBS) in patients with combined hepatocellular-cholangiocarcinoma (cHCC-CCA) remains unknown. This study aimed to investigate the impact of TBS on long-term outcomes after surgery.MethodsPatients who underwent radical-intent resection between June 2013 and December 2019 were retrospectively reviewed. Kaplan–Meier curves were used to analyze patient survival, and disease-free survival (DFS) and overall survival (OS) were examined in relation to TBS.ResultsA total of 178 patients were included in this study, with 119 in the training cohort and 59 in the validation cohort. Kaplan–Meier curves showed that TBS was a strong prognostic indicator in patients with cHCC-CCA. Elevated TBS was associated with poorer DFS and OS (both P-value < 0.001) and was identified as an independent prognostic indicator. In addition, the prognostic value of TBS outperformed tumor size and number alone, microvascular invasion, and lymph node invasion. The prognostic significance of TBS was confirmed by the internal validation cohort.ConclusionsThe present study suggested the significance of tumor morphology in assessing the prognosis of patients with cHCC-CCA who undergoing curative resection. The TBS is a promising prognostic index in patients with cHCC-CCA. Elevated TBS was related to a lower long-term survival rate and was identified as an independent risk factor for poor DFS and OS. Further research is needed to verify our results.

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“…The Fibrinogen/Albumin Ratio (FAR) is increasingly considered a potential biomarker for predicting prognosis in various diseases (43). In a study by Cicekli et al, it was reported that FAR levels might be useful in predicting mortality risk in COVID-19 patients (44).…”

Section: Discussionmentioning

confidence: 99%

May the fibrinogen to albumin ratio be a prognostic factor in acute mesenteric ischemia? Is it worth mentioning?

Muhtaroğlu

Çapoğlu

Uygur

et al. 2023

Preprint

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Objective: Acute mesenteric ischemia (AMI) is a vascular emergency resulting from decreased blood flow caused by the occlusion of the mesenteric vessels, hypoperfusion or vasospasm. This study aimed to investigate the prognostic value of the fibrinogen-to-albumin (FAR) ratio in patients with acute mesenteric ischemia. Methods: A total of 91 patients were enrolled in the study. Patients' demographics such as age and gender, pre- and postoperative hemoglobin, CRP, white blood cell (WBC), neutrophils, preoperative lymphocyte, alanine transaminase (ALT), aspartate transaminase (AST), thrombocytes and postoperative D-dimer values were recorded. In addition, pre- and postoperative fibrinogen and albumin levels were recorded and FAR was calculated. Patients were divided into two groups survivors and non-survivors. Results: The mean pre- and postoperative fibrinogen levels were statistically significantly higher in the non-survivor group than in the survivor group (p<0.001). The mean pre- and postoperative albumin levels were significantly lower in the non-survivors than in the survivors (p=0.059, p<0.001; respectively). The mean pre- and postoperative FAR ratios were considerably higher in the non-survivor than in the survivor groups (p<0.001). The change between pre- and postoperative fibrinogen, albumin and FAR values were statistically significant between the non-survivors and the survivors (for all, p<0.05). Conclusion: The preoperative and postoperative fibrinogen levels were significantly higher, and albumin levels were significantly lower in the survivor compared to the non-survivor patients with AMI. Furthermore, the preoperative and postoperative FAR ratio was significantly higher in the non-survivors. The FAR ratio may be a valuable prognostic biomarker for patients with AMI.

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The Fibrinogen/Albumin Ratio Index as an Independent Prognostic Biomarker for Patients with Combined Hepatocellular Cholangiocarcinoma After Surgery

Cited by 6 publications

References 33 publications

FAR Ratio as Prognostic Biomarker in AMI

FAR Ratio as Prognostic Biomarker in AMI

Tumor burden score dictates prognosis of patients with combined hepatocellular cholangiocarcinoma undergoing hepatectomy

May the fibrinogen to albumin ratio be a prognostic factor in acute mesenteric ischemia? Is it worth mentioning?

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