Fibrin thrombi, a cause of clindamycin-associated colitis?

Bogomoletz, W. V.

doi:10.1136/gut.17.6.483

Cited by 18 publications

(5 citation statements)

References 15 publications

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“…In elderly Swedish patients with C. difficile colitis, pulmonary embolism was the most frequent complication [30]. Rectal biopsies of patients with clindamycin-associated colitis revealed capillary thrombosis [31]. Thrombosis in cases 1 and 2 may have been promoted by the depletion of intravascular factors inhibiting coagulation [32,33] because of enteropathy or pseudomembrane formation, and by central venous catheterization [34] for infusions that contained clotting factors.…”

Section: Discussionmentioning

confidence: 99%

Clostridium difficile Colitis Associated with Infant Botulism: Near‐Fatal Case Analogous to Hirschsprung's Enterocolitis

Schechter¹,

Peterson²,

McGee³

et al. 1999

CLIN INFECT DIS

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We present the first five reported cases of Clostridium difficile-associated diarrhea (CDAD) in children with infant botulism caused by Clostridium botulinum. We compare two fulminant cases of colitis in children with colonic stasis, the first caused by infant botulism and the second caused by Hirschsprung's disease. In both children, colitis was accompanied by hypovolemia, hypotension, profuse ascites, pulmonary effusion, restrictive pulmonary disease, and femoral-caval thrombosis. Laboratory findings included pronounced leukocytosis, hypoalbuminemia, hyponatremia, coagulopathy, and, when examined in the child with infant botulism, detection of C. difficile toxin in ascites. CDAD recurred in both children, even though difficile cytotoxin was undetectable in stool after prolonged initial therapy. Four children who had both infant botulism and milder CDAD also are described. Colonic stasis, whether acquired, as in infant botulism, or congenital, as in Hirschsprung's disease, may contribute to the susceptibility to and the severity of CDAD.

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Section: Discussionmentioning

confidence: 99%

Clostridium difficile Colitis Associated with Infant Botulism: Near‐Fatal Case Analogous to Hirschsprung's Enterocolitis

Schechter¹,

Peterson²,

McGee³

et al. 1999

CLIN INFECT DIS

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“…Their evidence appears to be based on the absence of such capillary microthrombi in the 13 cases described as 'type 1 lesion' in their material. In a recent study undertaken in our department (Bogomoletz, 1976), the presence of capillary fibrin thrombi was demonstrated in rectal biopsies from five patients with clindamycin-associated colitis, three with pseudomembranous colitis, and two with non-specific colitis (the latter form appears to be an even earlier lesion than 'type 1 lesion'). Furthermore, capillary thrombosis with vasculitis has been described in rectal biopsies of other cases of clindamycinassociated colitis (Butsch et al, 1975).…”

Section: Discussionmentioning

confidence: 91%

A rapid blood lactate assay using a centrifugal analyser and 3-acetylpyridine-adenine dinucleotide.

Ewen¹,

Henderson²

1977

J Clin Pathol

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“…The histology of tissue from patients with pseudomembranous colitis suggests various causesa local Swartzman phenomenon (Hjort and Rapaport, 1965), ischaemia (McGovern and Goulston, 1965), or capillary thrombosis (Whitehead, 1971;Bogomoletz. 1976).…”

Section: Discussionmentioning

confidence: 99%