Effect of clindamycin and lincomycin therapy on faecal flora.

Leigh, D. A.; Simmons, Kate

doi:10.1136/jcp.31.5.439

Cited by 8 publications

(2 citation statements)

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“…Clindamycin administration has previously been shown to markedly suppress the anaerobic microbial community including members of the Bacteroides group, which account for ∼ 30% of the intestinal bacterial flora [ 2 , 27 , 28 ]. The change in the intestinal flora may interfere with intestinal enzyme DPP-IV (dipeptydal peptidase), which catalyzes the breakdown of proteins into amino acids, and has been hypothesized as a contributing factor to autism [ 29 ].…”

Section: Resultsmentioning

confidence: 99%

“…Propionic acid (PA) occurs naturally in a few food products; for example PA is present in low quantities in milk and relatively higher levels in dairy products such as yogurt and cheese, obviously due to bacterial fermentation, mostly by propionibacteria [ 1 , 2 ]. The food sources however have a minor contribution in the PA levels in the body [ 3 ].…”

Section: Introductionmentioning

confidence: 99%

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Possible ameliorative effects of antioxidants on propionic acid / clindamycin - induced neurotoxicity in Syrian hamsters

et al. 2013

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BackgroundPropionic acid (PA) found in some foods and formed as a metabolic product of gut bacteria has been reported to mimic/mediate the effects of autism. The present study was undertaken to compare the effect of orally administered PA with that of clindamycin-induced PA-microbial producers in inducing persistent biochemical autistic features in hamsters. The neuroprotective potency of carnosine and carnitine supplements against PA toxicity was also investigated.MethodsThe following groups were studied. 1. Control group, which received phosphate buffered saline orally, 2. Propionic acid treated group which were given PA at a dose of 250 mg/kg body weight/day for 3 days orally, 3. Clindamycin treated group which received a single dose of the antibiotic orogastrically at a dose of 30 mg/kg on the day of the experiment, 4. Carnosine-treated group which were given carnosine at a dose of 10 mg/kg body weight/day orally for one week, 5. Carnitine treated group given 50 mg/kg body weight/day carnitine orally daily for one week. Group 6. Carnosine followed by PA, Group 7. Carnitine followed by PA. Dopamine, adrenaline and noradrenaline, serotonin and Gamma amino-butyric acid (GABA) were measured in the cortex and medulla of the nine studied groups.ResultsPA administration caused significant decrease in the neurotransmitters in the brains of treated hamsters while clindamycin caused a significant decrease only in dopamine in hamster brains (cortex and medulla) and GABA in the cerebral cortex of the treated hamsters. Administration of carnosine and carnitine which are known antioxidants caused no significant changes in the levels of neurotransmitters when administered alone to hamsters. However when administered with PA both carnosine and carnitine restored the altered neurotransmitters to near normal levels.ConclusionCarnosine and carnitine may be used as supplements to protect against PA neurotoxicity.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Possible ameliorative effects of antioxidants on propionic acid / clindamycin - induced neurotoxicity in Syrian hamsters

et al. 2013

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Disturbance of the Intestinal Ecosystem by Antimicrobial Agents

Braga

1993

Drug-Induced Injury to the Digestive System

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Effect of erythromycin and clindamycin on the indigenous human anaerobic flora and new colonization of the gastrointestinal tract

Heimdahl¹,

Nord²

1982

Eur. J, Clin. Microbiol.

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Erythromycin and clindamycin were given orally to ten subjects in recommended doses for seven days in order to study the effects of these antibiotics on human flora. Saliva and faecal specimens were collected for up to 29 days after administration of the antibiotics. Erythromycin caused only minor changes in the saliva flora while the aerobic and anaerobic colon flora were considerably disturbed. Clindamycin depressed both the anaerobic saliva and colon flora. Both erythromycin and clindamycin induced new colonization of the oral cavity and colon. The levels of free volatile fatty acids sank in saliva and faeces when erythromycin and clindamycin were given. The ecological disturbances caused by antibiotics require further investigation and should be taken into consideration in therapy.

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Effect of clindamycin and lincomycin therapy on faecal flora.

Cited by 8 publications

References 34 publications

Possible ameliorative effects of antioxidants on propionic acid / clindamycin - induced neurotoxicity in Syrian hamsters

Possible ameliorative effects of antioxidants on propionic acid / clindamycin - induced neurotoxicity in Syrian hamsters

Disturbance of the Intestinal Ecosystem by Antimicrobial Agents

Effect of erythromycin and clindamycin on the indigenous human anaerobic flora and new colonization of the gastrointestinal tract

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