Fibrin-Targeted Perfluorocarbon Nanoparticles for Targeted Thrombolysis

Marsh, Jon N.; Senpan, Angana; Hu, Grace; Scott, Michael J.; Gaffney, Patrick J.; Wickline, Samuel A.; Lanza, Gregory M.

doi:10.2217/17435889.2.4.533

Cited by 97 publications

(69 citation statements)

References 32 publications

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“…This is achieved by concentrating the available drug at the desired site and permitting a lower systemic dose. A fibrin-specific, liquid perfluorocarbon nanoparticle that is surface modified to deliver the plasminogen activator streptokinase has been developed, which shows such characteristics [57]. Effective concentrations of targeted streptokinase were orders of magnitude lower than equivalently efficacious levels of free drug.…”

Section: Novel Ultrasound-mediated Drug Delivery Systems For Thrombolmentioning

confidence: 99%

Microbubbles for Thrombolysis of Acute Ischemic Stroke

Meairs

Culp

2009

Cerebrovasc Dis

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Improved treatment of acute ischemic stroke with ultrasound and microbubbles in combination with thrombolytic drugs shows great promise, but the optimal techniques, indications, and contraindications have not yet been well defined. Moreover, details such as microbubble dosage, delivery, required thrombolytic drug dosage, and optimal ultrasound characteristics all remain uncertain. Recent results suggest that ultrasound and microbubbles may be effective in clot lysis of ischemic stroke without additional thrombolytic drugs. Moreover, targeting thrombus with specific immunobubbles may improve the efficacy of sonothrombolysis. Safety remains a major concern in the further development of ultrasound-enhanced thrombolysis and extensive animal work is required to define the most promising methods to translate into human application.

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Section: Novel Ultrasound-mediated Drug Delivery Systems For Thrombolmentioning

confidence: 99%

Microbubbles for Thrombolysis of Acute Ischemic Stroke

Meairs

Culp

2009

Cerebrovasc Dis

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“…Targeting of clotdissolving therapeutics could potentially decrease the frequency of complications at the same time as simultaneously increasing treatment effectiveness by concentrating the available drug at the desired site and permitting a lower systemic dose. 65 Any new system must be simple and safe when widely used. If safety can be proven even in hemorrhagic strokes, it may well be possible to use some technique of microbubble-augmented US lysis or US-augmented thrombolysis in patients who have not yet been transported to the hospital for CT to determine the presence or absence of intracranial hemorrhage.…”

Section: Discussionmentioning

confidence: 99%

Progress in Sonothrombolysis for the Treatment of Stroke

Meairs

Alonso

Hennerici

2012

Stroke

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“…Using plasminogen activators in nanoparticle constructs capable of targeting clots could prevent blockage. Marsh et al investigated the use of streptokinase linked to perfl uorocarbon nanoparticles targeted towards fi brin and showed that a 1000-fold dose of free streptokinase would be required to achieve the levels of lysing caused by the streptokinase-enabled nanoparticles [ 70 ]. Using a more complex nanoparticle construct, Erdem et al and McCarthy et al used CLIOs that target fi brin and activated factor XIII, which crosslinks with fi brin during clot formation.…”

Section: Nanomaterials For Cardiovascular Molecular Imagingmentioning

confidence: 99%