Fibrin Sealant Reduces Pain after Tonsillectomy: Prospective Randomized Study

Abstract

The combined sEMG and pain score data indicate that the electrocautery hemostatic technique is more painful and traumatic than the sealant technique. Surface electromyography of swallowing is a simple, reliable evaluation method for postsurgical odynophagia complaints and might be used as an objective tool for pain assessment.

Circulating cytokines in patients undergoing tonsillectomy with fibrin glue

“…IL-6, and TNF-a elevation have also been associated with acute sickness behavior, depression, and anxiety in humans [16]. Recently, studies have assessed variables such as pain, dysphagia, and bleeding based on questionnaires and re-hospitalization follow up to evaluate the efficacy of fibrin glue in reducing pain and bleeding [1][2][3][4][5][6]. The outcome of these studies is controversial, because some authors claim the glue is effective in reducing pain and bleeding [1,4,5,17], while others claimed it to be ineffective [3,6].…”

“…Discrepancies among Quixil studies regarding clinical outcome may be associated with the haemostatic technique. While some authors used the fibrin glue as a haemostatic agent [1,4], others first used cauterization for hemostasis, causing more tissue damage, and then sprayed the glue [3][4][5][6].…”

“…Several methods including different surgical techniques have been suggested to reduce the associated post-operative morbidity [1][2][3][4][5][6]. Recently, fibrin glue has been debated as a haemostatic agent or sealant [1][2][3][4][5][6]. Fibrin glue (Quixil, Omrix Biopharmaceuticals, Israel) is a human fibrin glue sealant that is efficacious in preventing peri-operative bleeding in the fields of orthopedics, general surgery, and ophthalmology.…”

“…Quixil has been successfully used in managing epistaxis and bleeding during endonasal operations [7,8]. There is a discrepancy among several fibrin glue studies regarding post T&A morbidity [1][2][3][4][5][6]. These studies have assessed variables such as pain, dysphagia, and bleeding based on questionnaires and rehospitalization follow-up.…”

Mesh Fixation with Autologous Platelet-Rich Fibrin Sealant in Inguinal Hernia Repair

“…This is mainly due to the number of spontaneously dissolved seroma and hematoma found upon precise examination postoperatively at 2 weeks. The primary endpoint of chronic pain was expected to be low due to less nerve damage by sutures and improved hemostasis (thus not leading to a complication as this is associated with pain) by the autologous P-RFS [8,19] . Considerable pain and sensory disturbances were reported, emphasizing the main complication of pain following inguinal hernia repair.…”