2012
DOI: 10.1016/j.ijporl.2012.01.001
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Circulating cytokines in patients undergoing tonsillectomy with fibrin glue

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Cited by 5 publications
(6 citation statements)
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“…The present study revealed that bubaline fibrin glue treatment led to decreased mRNA expression of Tnfa and Il1b in a time-dependent manner, and a significant difference was noted compared to the non-treatment control. Our results are in accordance with a previous study which demonstrated that the levels of serum Tnfa were decreased in tonsillectomy patients treated with commercial fibrin glue [ 55 ]. In addition, it has been shown that utilization of fibrin sealant in periodontal flap closure led to decreased Il1b protein expression in the treatment sites, corresponding with the lower plaque deposition and gingival bleeding [ 22 ].…”
Section: Discussionsupporting
confidence: 93%
“…The present study revealed that bubaline fibrin glue treatment led to decreased mRNA expression of Tnfa and Il1b in a time-dependent manner, and a significant difference was noted compared to the non-treatment control. Our results are in accordance with a previous study which demonstrated that the levels of serum Tnfa were decreased in tonsillectomy patients treated with commercial fibrin glue [ 55 ]. In addition, it has been shown that utilization of fibrin sealant in periodontal flap closure led to decreased Il1b protein expression in the treatment sites, corresponding with the lower plaque deposition and gingival bleeding [ 22 ].…”
Section: Discussionsupporting
confidence: 93%
“…Two separate laboratory studies supported the use of fibrin sealant in vocal cord reconstruction either alone as a means of increasing collagen deposition [245] or in combination with chondrocytes to maintain vocal cord vibration characteristics [246]. In a prospective, randomized clinical study ( n = 40), patients treated with fibrin sealant coating of the tonsillar bed following tonsillectomy were found to have less postoperative inflammatory response as measured by circulating leukocytes, neutrophils, and cytokines [247]. Finally, a commentary highlighted the potential role of fibrin sealant with a porcine gelatin pledget and fibroblast growth factor to successfully close tympanic membrane perforations [248].…”
Section: Less Frequently Published Clinical Applications Of Fibrinmentioning
confidence: 99%
“…This led the authors to conclude that sealant acted as a barrier to reduce the systemic inflammatory response to surgery. 22 Despite this theory, our analysis discovered no significant difference in pain levels on comparison of diathermy plus fibrin sealant versus diathermy alone.…”
Section: Painmentioning
confidence: 62%
“…In a study of 40 patients who all underwent monopolar dissection and bipolar hemostasis, the half who were randomized to have fibrin sealant in addition to diathermy had a significantly lower concentration of circulating cytokines postoperatively. This led the authors to conclude that sealant acted as a barrier to reduce the systemic inflammatory response to surgery . Despite this theory, our analysis discovered no significant difference in pain levels on comparison of diathermy plus fibrin sealant versus diathermy alone.…”
Section: Discussionmentioning
confidence: 99%