Circulating cytokines in patients undergoing tonsillectomy with fibrin glue

Stiller-Timor, Liran; Goldbart, Aviv; Segal, N; Amash, Alaa; Huleihel, Mahmoud; Leiberman, Alberto; Tal, Asher; Holcberg, Gershon; Puterman, Moshe

doi:10.1016/j.ijporl.2012.01.001

Cited by 5 publications

(6 citation statements)

References 17 publications

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“…The present study revealed that bubaline fibrin glue treatment led to decreased mRNA expression of Tnfa and Il1b in a time-dependent manner, and a significant difference was noted compared to the non-treatment control. Our results are in accordance with a previous study which demonstrated that the levels of serum Tnfa were decreased in tonsillectomy patients treated with commercial fibrin glue [ 55 ]. In addition, it has been shown that utilization of fibrin sealant in periodontal flap closure led to decreased Il1b protein expression in the treatment sites, corresponding with the lower plaque deposition and gingival bleeding [ 22 ].…”

Section: Discussionsupporting

confidence: 93%

Efficacy of bubaline blood derived fibrin glue in silk ligature-induced acute periodontitis in Wistar rats

et al. 2021

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Background and Aim: Fibrin forms in the coagulation process, enhancing local hemostatic properties and promoting wound healing. The study aimed to evaluate the efficacy of bubaline-derived fibrin glue in silk ligature-induced periodontitis rats. Materials and Methods: Bubaline blood–derived fibrin glue was prepared using cryoprecipitation and cryocentrifugation. Periodontitis was induced in rats by placing 5-0 silk ligatures around the mandibular first molars. The animals were divided into two groups: (1) Non-treatment and (2) bubaline fibrin glue–treated groups. Plaque, gingival inflammation, and mobility index were scored on days 1, 7, and 14 after intervention. Histological examinations were performed. The mRNA expression of inflammatory cytokines and growth factors was evaluated using a real-time polymerase chain reaction. Ligature-induced periodontitis was confirmed by the increase in inflammatory cell infiltration as well as histological bone and attachment loss. Results: Compared to the non-treatment group, bubaline fibrin glue application reduced mononuclear cell infiltration into periodontal tissues corresponding to the reduction of collagen destruction. On days 7 and 14 after intervention, the inflammatory score and histological attachment loss were significantly lower in the bubaline fibrin glue–treated group than in the non-treatment group. A significant reduction in histological bone loss was observed in the treated group on day 7. Bubaline fibrin glue application led to a significant reduction of Tnfa and Il1b mRNA levels, while an increased expression of Pdgfa, Tgfb1, and Il10 was observed compared with the control. Conclusion: Bubaline fibrin glue could be beneficial in periodontitis treatment aiming to reduce inflammation and delay the progression of periodontal disease.

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Section: Discussionsupporting

confidence: 93%

Efficacy of bubaline blood derived fibrin glue in silk ligature-induced acute periodontitis in Wistar rats

et al. 2021

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“…Two separate laboratory studies supported the use of fibrin sealant in vocal cord reconstruction either alone as a means of increasing collagen deposition [245] or in combination with chondrocytes to maintain vocal cord vibration characteristics [246]. In a prospective, randomized clinical study ( n = 40), patients treated with fibrin sealant coating of the tonsillar bed following tonsillectomy were found to have less postoperative inflammatory response as measured by circulating leukocytes, neutrophils, and cytokines [247]. Finally, a commentary highlighted the potential role of fibrin sealant with a porcine gelatin pledget and fibroblast growth factor to successfully close tympanic membrane perforations [248].…”

Section: Less Frequently Published Clinical Applications Of Fibrinmentioning

confidence: 99%

Fibrin Sealant: The Only Approved Hemostat, Sealant, and Adhesive—a Laboratory and Clinical Perspective

2014

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Background. Fibrin sealant became the first modern era material approved as a hemostat in the United States in 1998. It is the only agent presently approved as a hemostat, sealant, and adhesive by the Food and Drug Administration (FDA). The product is now supplied as patches in addition to the original liquid formulations. Both laboratory and clinical uses of fibrin sealant continue to grow. The new literature on this material also continues to proliferate rapidly (approximately 200 papers/year). Methods. An overview of current fibrin sealant products and their approved uses and a comprehensive PubMed based review of the recent literature (February 2012, through March 2013) on the laboratory and clinical use of fibrin sealant are provided. Product information is organized into sections based on a classification system for commercially available materials. Publications are presented in sections based on both laboratory research and clinical topics are listed in order of decreasing frequency. Results. Fibrin sealant remains useful hemostat, sealant, and adhesive. New formulations and applications continue to be developed. Conclusions. This agent remains clinically important with the recent introduction of new commercially available products. Fibrin sealant has multiple new uses that should result in further improvements in patient care.

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“…This led the authors to conclude that sealant acted as a barrier to reduce the systemic inflammatory response to surgery. 22 Despite this theory, our analysis discovered no significant difference in pain levels on comparison of diathermy plus fibrin sealant versus diathermy alone.…”

Section: Painmentioning

confidence: 62%

“…In a study of 40 patients who all underwent monopolar dissection and bipolar hemostasis, the half who were randomized to have fibrin sealant in addition to diathermy had a significantly lower concentration of circulating cytokines postoperatively. This led the authors to conclude that sealant acted as a barrier to reduce the systemic inflammatory response to surgery . Despite this theory, our analysis discovered no significant difference in pain levels on comparison of diathermy plus fibrin sealant versus diathermy alone.…”

Section: Discussionmentioning

confidence: 99%

Hemostatic glues in tonsillectomy: A systematic review

Sproat

Radford

Hunt³

2015

The Laryngoscope

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Pain and bleeding are significant causes of morbidity post-tonsillectomy. We conclude that there is no significant evidence to support hemostatic glues over current techniques for reducing severity of these outcomes. Consequently, we do not recommended hemostatic glues for routine use in current clinical practice. Studies were generally of low quality and inadequately powered to detect a statistical difference, even when pooled. We advocate further research to facilitate future meta-analysis.

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Circulating cytokines in patients undergoing tonsillectomy with fibrin glue

Cited by 5 publications

References 17 publications

Efficacy of bubaline blood derived fibrin glue in silk ligature-induced acute periodontitis in Wistar rats

Efficacy of bubaline blood derived fibrin glue in silk ligature-induced acute periodontitis in Wistar rats

Fibrin Sealant: The Only Approved Hemostat, Sealant, and Adhesive—a Laboratory and Clinical Perspective

Hemostatic glues in tonsillectomy: A systematic review

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