Fibrin glues — the current state of knowledge

Goczyńska, Paulina; Lasocka, Joanna; Lachert, Elżbieta

doi:10.5603/jtm.2021.0012

Cited by 4 publications

(5 citation statements)

References 39 publications

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“…Studies evaluating the use of fibrin-based adjuncts have reported >80% success rates at achieving hemostasis on raw liver surfaces and have been found to be effective in patients with underlying coagulopathies 19,35,36 . Unfortunately, fibrin-based sealants typically require specialized equipment for deployment and require special storage considerations 37 . They are also expensive to produce, and some carry a tangible risk for viral transmission or allergic reactions ranging from skin reactions to anaphylaxis 37,38 .…”

Section: Discussionmentioning

confidence: 99%

“…19,35,36 Unfortunately, fibrin-based sealants typically require specialized equipment for deployment and require special storage considerations. 37 They are also expensive to produce, and some carry a tangible risk for viral transmission or allergic reactions ranging from skin reactions to anaphylaxis. 37,38 The two-ply pectin patches used in this study are stored at room temperature and are easy to apply without the need for specialized equipment.…”

Section: Discussionmentioning

confidence: 99%

“…37 They are also expensive to produce, and some carry a tangible risk for viral transmission or allergic reactions ranging from skin reactions to anaphylaxis. 37,38 The two-ply pectin patches used in this study are stored at room temperature and are easy to apply without the need for specialized equipment. This and the fact that pectin is a naturally occurring and abundant material make this product a potentially far cheaper alternative to currently available sealants.…”

Section: Discussionmentioning

confidence: 99%

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Pectin based biologic Velcro effectively seals traumatic solid organ and small bowel injuries

Williams

Prey

Francis

et al. 2023

J Trauma Acute Care Surg

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Pectin based biologic Velcro effectively seals traumatic solid organ and small bowel injuries

Williams

Prey

Francis

et al. 2023

J Trauma Acute Care Surg

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“…Despite the advantages of autologous products, commercial fibrin glue has become the most popular fibrin glue since it became available on the market in 1998. Pharmaceutical companies such as Tisseel from Baxter Healthcare produce commercial fibrin glue as a surgical additive [ 26 ]. It is produced and supplied in separate vials with a dual syringe delivery system, in which human-plasma-derived thrombin containing ionic calcium and a fibrinogen-containing anticoagulant are first separated into two vials.…”

Section: Evolution Of Platelet-rich Derivativesmentioning

confidence: 99%

Current Progress of Platelet-Rich Derivatives in Cartilage and Joint Repairs

Bai

Tang

et al. 2023

IJMS

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In recent years, several types of platelet concentrates have been investigated and applied in many fields, particularly in the musculoskeletal system. Platelet-rich fibrin (PRF) is an autologous biomaterial, a second-generation platelet concentrate containing platelets and growth factors in the form of fibrin membranes prepared from the blood of patients without additives. During tissue regeneration, platelet concentrates contain a higher percentage of leukocytes and a flexible fibrin net as a scaffold to improve cell migration in angiogenic, osteogenic, and antibacterial capacities during tissue regeneration. PRF enables the release of molecules over a longer period, which promotes tissue healing and regeneration. The potential of PRF to simulate the physiology and immunology of wound healing is also due to the high concentrations of released growth factors and anti-inflammatory cytokines that stimulate vessel formation, cell proliferation, and differentiation. These products have been used safely in clinical applications because of their autologous origin and minimally invasive nature. We focused on a narrative review of PRF therapy and its effects on musculoskeletal, oral, and maxillofacial surgeries and dermatology. We explored the components leading to the biological activity and the published preclinical and clinical research that supports its application in musculoskeletal therapy. The research generally supports the use of PRF as an adjuvant for various chronic muscle, cartilage, and tendon injuries. Further clinical trials are needed to prove the benefits of utilizing the potential of PRF.

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“…Klej fibrynowy stosuje się również w chirurgii ogólnej, stomatologii, chirurgii sercowo-naczyniowej, okulistycznej, torakochirurgii, neurochirurgii, laryngologii, ginekologii czy urologii, zwłaszcza u pacjentów z zaburzeniami krzepnięcia. [13] Powszechnie stosowaną grupą produktów uzyskiwanych z osocza są immunoglobuliny podawane domięśniowo (IMIG). Wśród dostępnych preparatów znajdziemy m.in.…”

Section: Przykłady Zastosowań Produktów Medycznych Uzyskanych Z Osoczaunclassified

The impact of educating blood donors on plasmapheresis and plasma applications on the availability of plasma-derived medicinal products

SUTKOWSKI

WILCZEWSKA

MATYKA

et al. 2023

J Educ Health Sport

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Introduction: Human plasma contains valuable proteins such as albumin, globulins and coagulation factors. These ingredients are used to obtain medicinal products (PDMPs - plasma-derived medicinal products) used in many fields of medicine. The growing number of indications for their use causes an increase in the demand for plasma collected from blood donors. Most donors, however, choose to donate whole blood, which provides a lower amount of plasma than plasmapheresis. Purpose of the study: This study aims to indicate the reasons why donors do not decide to donate plasma by apheresis, to show the role of informing donors about the plasmapheresis, about the uses of plasma collected and about the safety of the process. The work also presents examples of PDMPs applications that can be used in the process of educating donors, which may contribute to increasing the number of plasma donors and, at the same time, the availability of PDMPs. Material and methods: A review of scientific research (using Pubmed, Google Scholar databases), medical books and materials published on websites of institutions related to blood donation regulations was conducted. Results: The reasons why blood donors do not decide to donate plasma include, among others, longer donation time and lack of knowledge about plasmapheresis. The decision to donate plasma via plasmapheresis is influenced not only by the fact of informing the donor about such a possibility, but also by the content and manner of providing the information. Due to the greater amount of plasma obtained each time by plasmapheresis compared to the separation of whole blood, an increase in the number of donors undergoing plasmapheresis may indirectly positively affect the availability of plasma-derived medicinal products

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Fibrin glues — the current state of knowledge

Cited by 4 publications

References 39 publications

Pectin based biologic Velcro effectively seals traumatic solid organ and small bowel injuries

Pectin based biologic Velcro effectively seals traumatic solid organ and small bowel injuries

Current Progress of Platelet-Rich Derivatives in Cartilage and Joint Repairs

The impact of educating blood donors on plasmapheresis and plasma applications on the availability of plasma-derived medicinal products

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