Fibrin-fibrinogen degradation products in sera of normal infants and children.

Uttley, W. S.; Allan, A. G. E.; Cash, J. D.

doi:10.1136/adc.44.238.761

Cited by 8 publications

(9 citation statements)

References 24 publications

(19 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This may be due to low levels of plasminogen in normal newborn infants [6] and to lower levels in asphyetie and in premature infants [16]. On the other hand we have to take into consideration that most normal infants have FDP in serum during the first hours of life [26,27]. Finally the possibility remains that FDP already had been eliminated by the reticule-endothelial system, when we obtained the samples for coagulation studies.…”

Section: Discussionmentioning

confidence: 95%

Incidence of disseminated intravascular coagulation in the course of septicemia in newborn infants

1971

View full text Add to dashboard Cite

Abstract. Coagulation studies including platelet count, partial thrombop]astin time, prothrombin index, and assays of fibrinogen, prothrombin, proaccelerin, antihcmophilic globuline and fibrin(ogen) degradation products were carried out in 12 newborn infants afflicted with septicemia. All patients had a decrease of platelet counts. 8 patients showed characteristic signs of DIC. In 3 cases we found marked consumption and in 3 other cases mild forms of DIC. In 2 cases DIC had occurred a few days before we obtained samples. The remaining 4 patients exhibited as a result of endotoxinemia a low platelet count without affecting blood coagulation. The most reliable laboratory findings for the diagnosis of DIC seem to be reduced platelet counts and low levels of fibrinogen and factor V. Poor prognosis and a high mortality rate still characterize cases of septicemia in newborn infants. The immunological situation, the absence of Ig A and Ig M, and a frequent deficiency of pathognomonic symptoms are the causes most frequently cited [17,18]. As thrombocytopenia is a frequent finding in the course of septicemia in newborn infants, we attempted to determine, whether this is due to disseminated intravascular coagulation (DIC). Thromboeytopenia associated with a decrease of certain plasma coagulation factors and with secondary Key-Words:

show abstract

Section: Discussionmentioning

confidence: 95%

Incidence of disseminated intravascular coagulation in the course of septicemia in newborn infants

1971

View full text Add to dashboard Cite

show abstract

“…(control 12-0), serum FDP was 512 ,ug./ml. (normal 10-9 ± 4 7) (Uttley et al, 1969). Plasma fibrinogen was normal.…”

Section: Serum Levels Of Fibrin/fibrinogen Degradation Products In Thmentioning

confidence: 89%

“…Normal values of serum FDP are already known both for children (Uttley, Allan, and Cash, 1969) and for adults (Das et al, 1967), as measured by the tanned red cell haemagglutination inhibition immunoassay. We have been able to study serum FDP from an early stage in the presentation of a case of the haemolytic-uraemic syndrome and subsequently to follow progress during treatment with heparin.…”

Section: Serum Levels Of Fibrin/fibrinogen Degradation Products In Thmentioning

confidence: 99%

Serum levels of fibrin-fibrinogen degradation products in the haemolytic-uraemic syndrome.

Uttley¹

1970

Archives of Disease in Childhood

View full text Add to dashboard Cite

“…34 samples were obtained The mean serum FDP on 34 samples was 14 9 from 12 children with acute infection. Urine FDP ,ug/ml 4 13 * 5 SD, being significantly higher than the was greater,than 0 * 5 ,ug/ml in 13 of these specimens normal (10 *9+4 *3) (Uttley et al, 1969) !ie/ Albustjx 0*01> P >0001). A maximum serum FDP of 48 tug/ml was obtained in each of 3 patients while oedematous.…”

Section: Resultsmentioning

confidence: 67%

“…Nonspecific haemagglutinins were absorbed using a 25% suspension of sheep red cells in Alsever's solution (Burroughs Wellcome Ltd.) and FDP was estimated as previously described for serum samples (Uttley, Allan, and Cash, 1969) using the tanned red cell haemaglutination inhibition immunoassay. Results were expressed in ,Lg fibrinogen equivalent per ml original urine volume, for the benefit of comparison with the most frequently quoted adult studies.…”

Section: Methodsmentioning

confidence: 99%

Fibrin/fibrinogen degradation products in children with renal disease

Uttley¹,

Maxwell²,

Cash³

1974

Archives of Disease in Childhood

Self Cite

View full text Add to dashboard Cite

137. Fibrin/fibrinogen degradation products in children with renal disease. Fibrin/fibrinogen degradation products (FDP) were measured in the serum and urine of children with various forms of renal disease. Serum FDP was raised both with nephrosis and with active proliferative nephritis. Urine FDP was rarely present in nephrosis but was significantly increased during the active phase of proliferative nephritis and also in urinary tract infection with frank haematuria. Urinary FDP correlated with total urinary protein in proliferative nephritis but not in nephrosis, nor did it correlate with serum FDP in either condition. The major application of urinary FDP determination in clinical practice is as an indicator of activity and possible response to treatment in the management of active proliferative nephritis.

show abstract

Fibrin-fibrinogen degradation products in sera of normal infants and children.

Cited by 8 publications

References 24 publications

Incidence of disseminated intravascular coagulation in the course of septicemia in newborn infants

Incidence of disseminated intravascular coagulation in the course of septicemia in newborn infants

Serum levels of fibrin-fibrinogen degradation products in the haemolytic-uraemic syndrome.

Fibrin/fibrinogen degradation products in children with renal disease

Contact Info

Product

Resources

About