Fibrin Adhesive: Its Use in Selected Skin Grafting

Abstract

The use of a fibrin adhesive to ensure the fixation of skin grafts in difficult situations was evaluated in 27 patients. Fibrin adhesive offers a fast and safe alternative to conventional methods, especially when dealing with concavities or other surfaces where it is impossible to obtain adequate fixation and prevent graft slippage. This type of adhesive has been used before, but too rapid fibrinolysis and a low concentration of fibrinogen made the method of little practical use. The method has been considerably improved by the addition of aprotinin, which is a proteolytic inhibitor and the achievement of a sufficient concentration of fibrinogen by various means. The specific advantages are: easy handling reduction of operating time, the absence of haematoma and good fixation. The price is somewhat prohibitive, but can be justified in terms of the improved results and the time saved when dealing with severely burned patients. In contrast to the synthetic glues, fibrin-adhesive does not prevent graft take through mechanical obstruction.

A pilot study to evaluate the efficacy of fibrin glue in attaching full thickness skin graft in repair of cicatricial ectropion

“…[18][19][20][21][22] Use of fibrin glue has been showed to be effective in skin transplants. [6][7][8][9]23 However, periocular area poses a challenge during skin grafting due to constant movements of eyelid. There is a paucity of material on use of fibrin glue in eyelid reconstruction.…”

Köpeklerde Kornea Yaralarının Onarımında Organik Doku Yapıştırıcısı Fibrin Adeziv'in Etkileri

“…FA'in etkileri; hemostazı sağlaması, dokuda adezyon (yapışma) oluşturması ve yara iyileşmesine yardımcı olması şeklinde özetlenebilir (Seelich, 1982 (Lilius, 1987). Mellin (1986) yaptığı çalışmada, FA'in kapatıcı özelliği nedeniyle acil göz cerrahisinde kullanılmasını önermektedir.…”

“…Literatür verilerde, hastanın kendi serumu İle hazırlanmadan, sadece FA kiti komponentleri kullanılarak yapılan çalışmalarda, viral enfeksiyon ya da allerjik reaksiyon komplikasyonu bildirilmemiştir (Seelich, 1982;Buschmann, 1986a;Buschmann, 1986b;Flacinelli ve ark. 1986;Mellin, 1986;Steinkogler, 1986;Lilius, 1987 FA'in, pıhtılaşma reaksiyonuna benzer bir reaksiyonla çalışması nedeniyle hemostatik etkisinin bulunduğu bildirilmektedir (Seelich, 1982;Lilius, 1987;Zauberman 1988 (Seelich, 1982;Mellin, 1986;Laqoutte ve ark., 1989 …”

Evaluation of fibrin sealants in cutaneous wound closure

“…13 Another study showed that fibrin sealant provided mechanical strength in the first days of healing, when the wound possesses little independent mechanical strength. 3 Fibrin sealants have also been found to greatly decrease operating time 8,14 and have been reported to improve wound healing and the final scar. 1,6 The elimination of suture removal could be a great advantage, especially when working with children.…”