Fibre optic sensor with bio-membrane supported immobilized morin for aluminium determination

Yao, Shou Zhuo; Chen, Xiaoming; Nie, Li Hua

doi:10.1007/bf01242890

Cited by 10 publications

(3 citation statements)

References 8 publications

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“…To date, synthesis, spectral, electrochemical, antioxidant properties and/or protein interactions have been published for several complexes of Al (III), Ga (III) and In (III) with various flavonoid derivatives . However, the cytotoxic activity of Al (III)/Ga (III)/In (III) ‐ flavonoid complexes has only been marginally studied .…”

Section: Introductionmentioning

confidence: 99%

Cytotoxicity studies, DNA interaction and protein binding of new Al (III), Ga (III) and In (III) complexes with 5‐hydroxyflavone

Arbănași

Badea

Olar

et al. 2018

Applied Organom Chemis

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We report the synthesis and characterization of three new complexes of the natural flavonoid 5-hydroxyflavone (primuletin) and Al (III), Ga (III), In (III), respectively. The physico-chemical properties and structural features of these three novel compounds have been investigated by elemental and thermogravimetric analysis, molar conductance and several spectroscopic techniques, including FT-IR, UV-Vis and mass spectra. Based on the experimental data, the general chemical formula of the complexes iswhere M is the cation and n = 2 for Al (III), n = 0 for Ga (III), n = 1, for In (III); each one of the three 5-hydoxyflavone molecules acts as a monoanionic bidentate chelate ligand in the complexes. DFT calculations further sustain the proposed structures of the complexes. Cytotoxicity was studied using MTS assay on cervical, breast, colon and ovary adenocarcinoma cell lines.The central metal ions exert cytotoxic effects in a disparate manner: Al (III) enhances, while Ga (III) and In (III) decrease the cytotoxicity of the ligand.As a means to investigate the mechanism underlying the cytotoxic effects of the complexes, interactions with calf thymus DNA, human serum albumin and transferrin were also carried out.This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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Section: Introductionmentioning

confidence: 99%

Cytotoxicity studies, DNA interaction and protein binding of new Al (III), Ga (III) and In (III) complexes with 5‐hydroxyflavone

Arbănași

Badea

Olar

et al. 2018

Applied Organom Chemis

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“…Morin is only weakly fluorescent in nature; however, when chelated with nonparamagnetic metal ions, especially Al 3+ and Be 2+ , it forms highly fluorescent complexes. So, this complexing reagent had been widely used for the fluorimetric determination of Al 3+ and other metal ions [17,18]. It was reported that when morin immobilized on solid support, it exhibited high selectivity for Al 3+ over other cations such as Ca 2+ , Co 2+ , and Pb 2+ [18,19].…”

Section: Introductionmentioning

confidence: 99%

Separation/Preconcentration Methods for the Determination of Aluminum in Dialysate Solution and Scalp Hair Samples of Kidney Failure Patients

Khan

Kazi

Baig

et al. 2011

Biol Trace Elem Res

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A new method is reported for the separation of aluminum ions (Al(3+)) from interfering cations in pharmaceutical and biological samples through solid-phase extraction (SPE) using 2-methyl-8-hydroxyquinoline (8-hydroxyquinaldine) on activated silica. While separated Al(3+) was preconcentrated by cloud point extraction (CPE) using 3,5,7,2'-4'-pentahydroxyflavone (morin) as complexing reagent, the resulting complex was entrapped in nonionic surfactant (Triton X-114) as prior step to its determination by spectrofluorimetry (SPF). The validity of separation/preconcentration of Al(3+) was checked by certified reference material of human hair and standard addition method. The chemical variables affecting the analytical performance of the separation/preconcentration methods were studied and optimized. The enrichment factor and detection limit of Al(3+) for the preconcentration of 10 ml of dialysate solution and acid-digested samples of scalp hair samples were found to be 25 and 0.34 μg/L, respectively. The relative standard deviation for six replicates of standard containing 20 μg/L of Al(3+) was <10%. In all DS, the concentration of Al was >10 μg/L. The level of Al in scalp hair samples of kidney failure patients was higher than healthy controls.

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“…22 Morin is a well-studied type of a fluorophore that is predominantly used for the detection of aluminium in solutions with recent attempts focused on chemical modifications for sensing purposes. [23][24][25][26] However, resulting optodes often did not yield required sensitivity and selectivity towards Al 3+ as such dye readily binds other metal ions that are commonly encountered in physiological samples such as magnesium or calcium. 10,27 Furthermore, small binding affinity for Al 3+ at circumneutral pH makes it unsuitable for real-time clinical measurements.…”

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confidence: 99%

Self-plasticized, lumogallion-based fluorescent optical sensor for the determination of aluminium (III) with ultra-low detection limits

Mendecki

Granados-Fócil

Jendrlin

et al. 2020

Analytica Chimica Acta

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Fibre optic sensor with bio-membrane supported immobilized morin for aluminium determination

Cited by 10 publications

References 8 publications

Cytotoxicity studies, DNA interaction and protein binding of new Al (III), Ga (III) and In (III) complexes with 5‐hydroxyflavone

Cytotoxicity studies, DNA interaction and protein binding of new Al (III), Ga (III) and In (III) complexes with 5‐hydroxyflavone

Separation/Preconcentration Methods for the Determination of Aluminum in Dialysate Solution and Scalp Hair Samples of Kidney Failure Patients

Self-plasticized, lumogallion-based fluorescent optical sensor for the determination of aluminium (III) with ultra-low detection limits

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