We have exploited a laser-based integration process of ultra-thin Metal-Oxide (MO) films in order to improve the plasmonic effect in sensors based on D-shaped Plastic Optical Fibers (POFs). More specifically, by using ultra-thin MO films, the performances of the Surface Plasmon Resonance (SPR) phenomenon improve and a Lossy Mode Resonance (LMR) can occur. Although the role of this kind of materials has been already presented, when they are deposited as overlayer (upside the thin metal film), we have used a different approach by depositing MOs, specially Zirconium Oxide (ZrO 2 ) and Titanium Oxide (TiO 2 ), as flexible intermediate layers between the exposed core of POFs and the gold film. The MO layer is prepared from sol-gel solution and Deep-UV laser curing allows to densify the thin film and tune the refractive index, with a room temperature process fully compatible with the flexible polymer substrates. In a preliminary step, we have carried out numerical results, based on transfer matrix formalism, in order to predict the SPR response. Subsequently, we have experimentally characterized the developed sensor configurations. Numerical and experimental results have shown above all an enhancement of the sensor performances, in terms of SPR sensitivity, with respect to a reference sensor based on a polymer instead of MOs. Moreover, in some proposed sensor configurations, together with the SPR phenomenon, an LMR phenomenon was observed. It occured in a different wavelength range, for a typical refractive index range present when considering receptors for biochemical sensing applications. Therefore, both resonances (SPR and LMR) could be used in several application fields.