Fiber-optic biosensor based on lossy mode resonances

A high-sensitivity fiber-optic evanescent wave sensor with a three-layer structure composed of Canada balsam doped with GeO2

“…Furthermore, the figure shows that the RCTLI_IVs of the three sensors can also accurately describe the dynamic process of the secondary antibody response, and the RCTLI_IVs maintained a stable level after 320 s. The response time of the sensors is attributed to the density of fixed mouse IgG isotype on the sensing region of the sensors, the affinity between the fixed staphylococcal protein A which is not bound to the mouse IgG and anti-mouse IgG (the goat anti-mouse IgG will bind to the protein A), and affinity between the mouse IgG and anti-mouse IgG (the affinity determines the adsorption and desorption rates of the secondary antibody in the sensing region) (Voisin et al, 2014). The assay time is comparable with the times indicated for previously reported biosensors, including a self-contained fiber-optic immunosensors for to measuring myoglobin with response times of 15-130 min (Hanbury et al, 1997), a fiber-optic biosensor based on lossy mode resonances for detecting immunoglobulins with a response time of 12 min (Socorro et al, 2012), an impedimetric transducer polyethyleneimine modified impedimetric transducer for bacteria detection with a response time of approximately 20 min (Brosel-Oliu et al, 2015), and a label-free fiber optic biosensor based on a long period grating (LPG) for the detection of in situ DNA hybridization with a response time of approximately 5 min (Gonçalves et al, 2015). Fig.…”

Lossy Mode Resonance (LMR) Based Fiber Optic Sensors: A Review

“…Sputtering technique is beneficial for mass production of refractometers due to its relatively less deposition time as compared to LbL and dip coating techniques reported in literature [5], [16], [18]. In another sensing application, LMR based fiber optic immunoglobulin G (IgG) biosensor was fabricated by depositing PAH/PSS thin films over unclad portion of the fiber [26]. These films support the lossy modes and also provide a suitable medium for IgG-anti-IgG immunoreactions.…”

Coatings for Optical Fiber Sensors

“…Using this concept, it has been demonstrated that this effect is useful to create optical fiber refractometers (99), humidity sensors (100), pH sensors (101), and also biosensors (102). In most of the cases, an indium tin oxide (ITO) thin layer was used as the LMR generating layer, and afterward a sensitive coating was created over the ITO layer.…”