Fiber-integrated frequency-doubling of a picosecond Raman laser to 560 nm

Runcorn, T. H.; Legg, T. H.; Murray, R.; Kelleher, E. J. R.; Попов, С. В.; Taylor, J.R.

doi:10.1364/oe.23.015728

Cited by 18 publications

(12 citation statements)

References 12 publications

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“…Fibre-based laser beam delivery is also compatible with many other optical imaging systems; e.g., it can easily be attached to any confocal microscope with suitable detectors and integrated with existing endoscopy systems 60,61 through fibre connections to realize compact and user-friendly CRS imaging for use in surgery and diagnostics 62 . The current implementation can potentially be upgraded in the following two ways: (1) for fast spectroscopic imaging, the wavenumber tuning speed can be largely increased by replacing the existing spectral filters with electronically controlled all-fibre Fabry-Pérot filters that can easily operate at speeds of >100 kHz and have widely been used to build fast wavelength-swept laser sources for high-speed optical coherence tomography 63 ; (2) to fully utilize the appealing advantages of fibre lasers for flexible beam delivery, the frequency doubling of the pump beam, which is currently performed in free space, can be replaced with a fibre-integrated PPLN module 64 , resulting in an even more compact and robust system.…”

Section: Discussionmentioning

confidence: 99%

High-contrast, fast chemical imaging by coherent Raman scattering using a self-synchronized two-colour fibre laser

et al. 2020

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Coherent Raman scattering (CRS) microscopy is widely recognized as a powerful tool for tackling biomedical problems based on its chemically specific label-free contrast, high spatial and spectral resolution, and high sensitivity. However, the clinical translation of CRS imaging technologies has long been hindered by traditional solid-state lasers with environmentally sensitive operations and large footprints. Ultrafast fibre lasers can potentially overcome these shortcomings but have not yet been fully exploited for CRS imaging, as previous implementations have suffered from high intensity noise, a narrow tuning range and low power, resulting in low image qualities and slow imaging speeds. Here, we present a novel high-power self-synchronized two-colour pulsed fibre laser that achieves excellent performance in terms of intensity stability (improved by 50 dB), timing jitter (24.3 fs), average power fluctuation (<0.5%), modulation depth (>20 dB) and pulse width variation (<1.8%) over an extended wavenumber range (2700-3550 cm −1). The versatility of the laser source enables, for the first time, high-contrast, fast CRS imaging without complicated noise reduction via balanced detection schemes. These capabilities are demonstrated in this work by imaging a wide range of species such as living human cells and mouse arterial tissues and performing multimodal nonlinear imaging of mouse tail, kidney and brain tissue sections by utilizing second-harmonic generation and twophoton excited fluorescence, which provides multiple optical contrast mechanisms simultaneously and maximizes the gathered information content for biological visualization and medical diagnosis. This work also establishes a general scenario for remodelling existing lasers into synchronized two-colour lasers and thus promotes a wider popularization and application of CRS imaging technologies.

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Section: Discussionmentioning

confidence: 99%

High-contrast, fast chemical imaging by coherent Raman scattering using a self-synchronized two-colour fibre laser

et al. 2020

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“…147 It should also be noted that it is possible to fiber integrate the complete configuration by fiber pig-tailing the nonlinear crystal assembly. 148 With up to 50% conversion efficiency obtained at 560 nm for pump powers of about 3 W, as shown in Fig. 18, pulse durations were also selectable from 100 ps to 2.7 ns [see Fig.…”

Section: Visible Generation Through Second Harmonic Generation Of Fibmentioning

confidence: 96%

Tutorial on fiber-based sources for biophotonic applications

Taylor

2016

J. Biomed. Opt

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Abstract. Fiber-based lasers and master oscillator power fiber amplifier configurations are described. These allow spectral versatility coupled with pulse width and pulse repetition rate selection in compact and efficient packages. This is enhanced through the use of nonlinear optical conversion in fibers and fiber-coupled nonlinear crystals, which can be integrated to provide all-fiber pump sources for diverse application. The advantages and disadvantages of sources based upon supercontinuum generation, stimulated Raman conversion, four-wave mixing, parametric generation and difference frequency generation, allowing spectral coverage from the UV to the mid-infrared, are considered.

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“…The main drawback of synchronously pumped Raman lasers is that the pump repetition rate needs to be precisely tuned to the Raman cavity length, thereby precluding repetition rate adjustment and pulse-duration tunability. To overcome this limitation, in our recent works we used narrow linewidth continuous-wave (CW) signals to seed Raman amplifiers that were pulse-pumped using Yb:fiber MOPA systems [30]- [32].…”

Section: Seeded Raman Amplificationmentioning

confidence: 99%

Visible Raman-Shifted Fiber Lasers for Biophotonic Applications

Runcorn

Görlitz

Murray

et al. 2018

IEEE J. Select. Topics Quantum Electron.

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The efficient nonlinear conversion of Yb-doped fiber laser systems using a combination of stimulated Raman scattering and second-harmonic generation is an effective method for developing sources for biophotonic applications in the yellowgreen spectral region. In this paper, we review recent progress in the development of these sources, compare the relative benefits of differing source architectures and demonstrate STED microscopy using an exemplar source.

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Fiber-integrated frequency-doubling of a picosecond Raman laser to 560 nm

Cited by 18 publications

References 12 publications

High-contrast, fast chemical imaging by coherent Raman scattering using a self-synchronized two-colour fibre laser

High-contrast, fast chemical imaging by coherent Raman scattering using a self-synchronized two-colour fibre laser

Tutorial on fiber-based sources for biophotonic applications

Visible Raman-Shifted Fiber Lasers for Biophotonic Applications

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