Fiber enriched diets and radiation induced injury of the gut

Kapkaç, Murat; Erikoğlu, Mehmet; Tuncyurek, Pars; Ersin, Sinan; Esassolak, Mustafa; Alkanat, Murat; Sipahioglu, Oguz

doi:10.1016/s0271-5317(02)00490-6

Cited by 12 publications

(7 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Beneficial effects of prebiotics are also associated with the generation of short-chain fatty acids (SCFA) due to fermentation by colonic bacteria [81]. SCFA may effectively protect intestinal structure against radiation-induced damage by improving mucosal integrity [82]. Synbiotics are defined as mixtures of probiotics and prebiotics that beneficially affect host intestinal health with their reinforced synergistic action [83].…”

Section: Probiotics Prebiotics and Synbioticsmentioning

confidence: 99%

Antioxidant Properties of Probiotics and Their Protective Effects in the Pathogenesis of Radiation-Induced Enteritis and Colitis

et al. 2010

View full text Add to dashboard Cite

Radiation therapy has become one of the most important treatment modalities for human malignancy, but certain immediate and delayed side-effects on the normal surrounding tissues limit the amount of effective radiation that can be administered. After exposure of the abdominal region to ionizing radiation, nearly all patients experience transient symptoms of irradiation of the bowel. Acute-phase symptoms may persist for a short time, yet long-term complications can represent significant clinical conditions with high morbidity. Data from both experimental studies and clinical trials suggest the potential benefit for probiotics in radiation-induced enteritis and colitis. On the other hand, it is well evidenced that both useful and harmful effects of therapeutic applications of ionizing radiation upon living systems are ascribed to free-radical production. Therefore, the hypothesis that probiotics reinforce antioxidant defense systems of normal mucosal cells exposed to ionizing radiation may explain to an extent their beneficial action. The aim of this review is threefold: First, to make a short brief into the natural history of radiation injury to the intestinal tract. Second, to describe the primary interaction of ionizing radiation at the cellular level and demonstrate the participation of free radicals in the mechanisms of injury and, third, to try a more profound investigation into the antioxidant abilities of probiotics and prebiotics based on the available experimental and clinical data.

show abstract

Section: Probiotics Prebiotics and Synbioticsmentioning

confidence: 99%

Antioxidant Properties of Probiotics and Their Protective Effects in the Pathogenesis of Radiation-Induced Enteritis and Colitis

et al. 2010

View full text Add to dashboard Cite

show abstract

“…Consequently, a large number of studies have been carried out to investigate the clinical entities that impair the gut barrier function [3,[39][40][41][42][43] . In the absence of bile salts, the intestinal motility was decreased, and bacterial overgrowth and mucosal atrophy were initiated [44][45][46] .…”

Section: Discussionmentioning

confidence: 99%

Does Pharmaconutrition with <i>L</i>-Arginine and/or α-Tocopherol Improve the Gut Barrier in Bile Duct Ligated Rats?

Tuncyurek

Sarı²,

Fırat³

et al. 2006

Eur Surg Res

View full text Add to dashboard Cite

Background/Aim: Nitric oxide supplementation and antioxidant therapy modulate gut barrier function, but the relationships between enhanced nitric oxide production, antioxidant administration, and biliary obstruction remain unclear. We evaluated the role of nitric oxide and α-tocopherol supplementation in bile duct ligated rats. Methods: Fifty male Wistar albino rats underwent sham operation (group I; control animals) or bile duct ligation (groups II, III, IV, and V). The ligation groups received the following regimens: standard pellet diet (group II), pellet diet plus intramuscularly administerd α-tocopherol (group III), and L-arginine-enriched pellet diet without (group IV) or with (group V) α-tocopherol. Nitric oxide, malondialdehyde, and α-tocopherol concentrations were assessed at the end of 3 weeks. Liver and intestinal samples were scored histologically. Mesenteric lymph node and liver cultures were assessed for bacterial translocation. Results: The liver malondialdehyde concentration was highest in group III. The nitric oxide content in the liver was higher in groups III and V, as were the blood α-tocopherol levels. Bacterial translocation was evident following bile duct ligation, but did not differ among the treatment groups. Intestinal histology revealed that group III had the lowest villus height, that group V had the least villus count, and that group II had the highest mucous cell count. The fibrosis scores were higher in groups IV and V. Conclusions: An obvious effect of α-tocopherol (with or without L-arginine) on the gut barrier could not be demonstrated. Moreover, the L-arginine-enriched diet promoted fibrosis in the liver. Thus, while biliary duct obstruction triggers bacterial translocation, nitric oxide and/or α-tocopherol supplementation did not seem to improve the gut barrier in our model.

show abstract

“…Despite the literature acknowledging the effect of rectal volume on prostate position 4-16 (large rectal volumes push the prostateanteriorly),thereisalackofresearchspecificallyaimed atlookingathowdietaffectsthedailyrectalvolumesofpatients having radiation therapy. However, it is generally accepted that good nutrition will assist in the body's ability to repair healthy cellsdamagedbyirradiation,thusreducingsideeffects.Kapkac et al 39 havesuccessfullyshownthisinrats,wherefibreenriched diets effectively protected intestinal structure against radiation induceddamagebyimprovingmucosalintegrity.…”

Section: B What Instructions Are Given To Patients In Regards To Diet?mentioning

confidence: 94%

Patient positioning and treatment instructions used during radiation therapy of the prostate: results of an Australian and New Zealand survey

Knight

2005

Radiographer

View full text Add to dashboard Cite

Nationalstandardsforpatientpositioningandtreatmentinstructionsforradiationtherapyofprostatecancer arenon-existent.Tomaximisedailyreproducibilityofthepatient'sposition,immobilisationandstabilisationdevices areoftenused.Tominimiseprostatemotion,patientsmaybegiveninstructionstoregulaterectalandbladdervolumes. However,theuseofthesepatientpositioningdevicesandtheprovisionofpatienttreatmentinstructionsvarybetween radiationtherapycentres.InMay2003asurveywassenttoallradiationtherapychiefsthroughoutAustraliaandNew Zealandrequestinginformationregardingthetreatmentofprostatecancerpatients.Thiscomprehensivereviewofcurrentpracticesclearlydemonstratesdifferencesbetweencentresontheuseofpatientinstructionstoregulaterectaland bladdercontents,however,stabilisationandimmobilisationmethodsprovedtobemoreconsistent.Theresultswillbe discussedinlightofthecurrentinternationalliteratureregardingpatientpositioningandpatienttreatmentinstructions usedduringradiationtherapyoftheprostate.Thisreviewhasidentifiedlimitedareasofconsensus,andhighlightedthe needtodevelopcommonprotocolsandbenchmarkingofstandardsinordertoimprovetreatmentdelivery.

show abstract

Fiber enriched diets and radiation induced injury of the gut

Cited by 12 publications

References 14 publications

Antioxidant Properties of Probiotics and Their Protective Effects in the Pathogenesis of Radiation-Induced Enteritis and Colitis

Antioxidant Properties of Probiotics and Their Protective Effects in the Pathogenesis of Radiation-Induced Enteritis and Colitis

Does Pharmaconutrition with <i>L</i>-Arginine and/or α-Tocopherol Improve the Gut Barrier in Bile Duct Ligated Rats?

Patient positioning and treatment instructions used during radiation therapy of the prostate: results of an Australian and New Zealand survey

Contact Info

Product

Resources

About