Does Pharmaconutrition with &lt;i&gt;L&lt;/i&gt;-Arginine and/or α-Tocopherol Improve the Gut Barrier in Bile Duct Ligated Rats?

Tuncyurek, Pars; Sarı, Mustafa; Fırat, Özgür; Mutaf, Isil; Gülter, Ceyda; Tünger, Alper; Yüce, Gül; Yılmaz, Mustafa; Makay, Özer; Dayangaç, Murat; Ersin, Sinan

doi:10.1159/000091479

Cited by 3 publications

(1 citation statement)

References 88 publications

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“…Antioxidants α-tocopherol limited data (Tuncyurek et al, 2006;Andiran et al, 2000) isolated reports on NASH patients (Harrison et al, 2003;Hasegawa et al, 2001) S-adenosyl-methionine positive data (Nieto et al, 2005) effective in alcohol-induced fibrosis (Mato et al, 1999) Sho-saiko-to positive data (Shimizu et al, 1999;Sakaida et al, 1998) limited data quercetin limited data (Lee et al, 2003;Pavanato et al, 2003) not tested…”

Section: Effects Inclinical Trialsmentioning

confidence: 99%

Addressing Liver Fibrosis with Liposomes Targeted to Hepatic Stellate Cells

Adrian¹,

Poelstra²,

Kamps³

2007

Journal of Liposome Research

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Liver fibrosis is a chronic disease that results from hepatitis B and C infections, alcohol abuse or metabolic and genetic disorders. Ultimately, progression of fibrosis leads to cirrhosis, a stage of the disease characterized by failure of the normal liver functions. Currently, the treatment of liver fibrosis is mainly based on the removal of the underlying cause of the disease and liver transplantation, which is the only treatment for patients with advanced fibrosis. Hepatic stellate cells (HSC) are considered to be key players in the development of liver fibrosis. Chronically activated HSC produces large amounts of extracellular matrix and enhance fibrosis by secreting a broad spectrum of cytokines that exert pro-fibrotic actions in other cells, and in an autocrine manner perpetuate their own activation. Therefore, therapeutic interventions that inhibit activation of HSC and its pro-fibrotic activities are currently under investigation worldwide. In the present study we applied targeted liposomes as drug carriers to HSC in the fibrotic liver and explored the potential of these liposomes in antifibrotic therapies. Moreover, we investigated effects of bioactive compounds delivered by these liposomes on the progression of liver fibrosis. To our knowledge, this is the first study demonstrating that lipid-based drug carriers can be selectively delivered to HSC in the fibrotic liver. By incorporating the bioactive lipid DLPC, these liposomes can modulate different processes such as inflammation and fibrogenesis in the fibrotic liver. This dual functionality of liposomes as a drug carrier system with intrinsic biological effects may be exploited in new approaches to treat liver fibrosis.

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Section: Effects Inclinical Trialsmentioning

confidence: 99%

Addressing Liver Fibrosis with Liposomes Targeted to Hepatic Stellate Cells

Adrian¹,

Poelstra²,

Kamps³

2007

Journal of Liposome Research

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Effects of omega-3 fatty acid plus alpha-tocopherol supplementation on malnutrition–inflammation score, biomarkers of inflammation and oxidative stress in chronic hemodialysis patients

et al. 2016

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The Effects of L-Ornitine and L-Arginine on the Processes of Lipid Peroxidation in the Functional Layers of Kidneys on the Background of Acute Toxic Hepatitis

et al. 2020

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The aim is to evaluate the effects of L-arginine and L-ornithine on the processes of lipid peroxidation in homogenates of renal cortex, renal medulla and renal papilla under conditions of acute toxic hepatitis. Materials and methods: The study was performed on 40 outbred white male rats with experimental hepatitis, caused by carbon tetrachloride. The animals were divided into five groups: control group (the rats were simulated carbon tetrachloride poisoning and its correction by administering of olive oil and normal saline in equivalent doses), acute carbon tetrachloride hepatitis (single intraperitoneal injection of 50% carbon tetrachloride oil solution at the dose of 2 mlxkg-1 of body weight and simulation of treatment by administration of normal saline in equivalent doses), acute carbon tetrachloride hepatitis + L-ornithine (1000 mgxkg-1), acute carbon tetrachloride hepatitis + L-arginine (500 mgxkg-1) and acute carbon tetrachloride hepatitis + combination of substances. Results: On the background of acute carbon tetrachloride intoxication it was observed the development of renal failure in experimental animals, manifested by activation of lipid peroxidation processes in homogenates of renal cortex, renal medulla and renal papilla. The administration of L-ornithine and L-arginine demonstrates positive impact on renal function and hepato-renal syndrome by stabilization of cell membranes and regeneration of functional capacity of injured renal cells. Conclusions: The results of our study confirm both the presence of unidirectional effects and absence of toxic influences of L-ornithine and L-arginine on renal cells under the conditions of acute carbon tetrachloride intoxication, which are the most important requirements for modern drugs for the treatment of hepato-renal syndrome.

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Does Pharmaconutrition with <i>L</i>-Arginine and/or α-Tocopherol Improve the Gut Barrier in Bile Duct Ligated Rats?

Cited by 3 publications

References 88 publications

Addressing Liver Fibrosis with Liposomes Targeted to Hepatic Stellate Cells

Addressing Liver Fibrosis with Liposomes Targeted to Hepatic Stellate Cells

Effects of omega-3 fatty acid plus alpha-tocopherol supplementation on malnutrition–inflammation score, biomarkers of inflammation and oxidative stress in chronic hemodialysis patients

The Effects of L-Ornitine and L-Arginine on the Processes of Lipid Peroxidation in the Functional Layers of Kidneys on the Background of Acute Toxic Hepatitis

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