Effects of omega-3 fatty acid plus alpha-tocopherol supplementation on malnutrition–inflammation score, biomarkers of inflammation and oxidative stress in chronic hemodialysis patients

Asemi, Zatollah; Soleimani, Alireza; Shakeri, Hossein; Mazroii, Navid; Esmaillzadeh, Ahmad

doi:10.1007/s11255-016-1399-4

Cited by 29 publications

(40 citation statements)

References 32 publications

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“…When omega 3 treatment with 1600 mg EPA and 300 mg DHA was associated with or without 400 IU of α-tocopherol, and compared with placebo for 12 weeks, increased plasma nitric oxide (+31.0 ± 40.0 µmol/L, p < 0.01), and increased total antioxidant capacity (TAC) (+57.6 ± 157.8 mmol/L, p < 0.01) were observed. No effect was seen on hsCRP and glutathione (GSH), while albumin and malnonyldialdehyde (MDA) levels where changed only when EPA and DHA were associated with α-tocopherol [ 42 ]. Omega 3 treatment in chronic kidney disease patients with 1840 mg EPA and 1520 mg DHA daily was also associated with or without 200 mg coenzyme Q10 (CoQ) for 8 weeks, and compared to placebo [ 43 ].…”

Section: Resultsmentioning

confidence: 99%

Update on the Impact of Omega 3 Fatty Acids on Inflammation, Insulin Resistance and Sarcopenia: A Review

Stella

Cappellari

Barazzoni

et al. 2018

IJMS

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Elderly and patients affected by chronic diseases face a high risk of muscle loss and impaired physical function. Omega 3 fatty acids (FA) attenuate inflammation and age-associated muscle loss, prevent systemic insulin resistance and improve plasma lipids, potentially impacting on sarcopenia. This paper aims to review recent randomized clinical studies assessing the effects a chronic omega 3 FA supplementation on inflammatory and metabolic profile during conditions characterized by sarcopenia (aging, insulin resistance, type 2 diabetes, chronic renal failure). A comprehensive search of three online databases was performed to identify eligible trials published between 2012 and 2017. A total of 36 studies met inclusion criteria. Omega 3 FA yielded mixed results on plasma triglycerides in the elderly and no effects in renal patients. No changes in systemic insulin resistance were observed. Inflammation markers did not benefit from omega 3 FA in insulin resistant and in renal subjects while decreasing in obese and elderly. Muscle related parameters improved in elderly and in renal patients. In conclusion, in aging- and in chronic disease-associated sarcopenia omega 3 FA are promising independently of associated anabolic stimuli or of anti-inflammatory effects. The evidence for improved glucose metabolism in insulin resistant and in chronic inflammatory states is less solid.

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Section: Resultsmentioning

confidence: 99%

Update on the Impact of Omega 3 Fatty Acids on Inflammation, Insulin Resistance and Sarcopenia: A Review

Stella

Cappellari

Barazzoni

et al. 2018

IJMS

View full text Add to dashboard Cite

show abstract

“…It may be possible to address inflammation either directly through administration of IL-1 inhibitors (18), IL-1 receptor antagonists (19,20), or TNF-a inhibitors (21) or indirectly by administering omega fatty acids (22,23) or nutritional supplements (23). Nutritional supplementation and anti-inflammatory interventions have also been shown to improve nutritional status (21,24).…”

Section: Discussionmentioning

confidence: 99%

Factors Associated with Frailty and Its Trajectory among Patients on Hemodialysis

Johansen

Dalrymple

Delgado

et al. 2017

CJASN

128

113

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“…Group C showed significantly better results than both Groups A and B, substantiating that endothelial function had indeed improved very significantly with the addition of PCC to fish oil. The probable mechanism in improved NO levels could be as reported by Asemi et al 57 We assume that the combination of fish oil with PCC is more beneficial than fish oil alone.…”

Section: Discussionmentioning

confidence: 58%

“…Impaired bioavailability of NO represents an essential feature of EnD. 56 In a 12-week study by Asemi et al, 57 ω-3FA alone and its combination with alpha-tocopherol significantly increased NO levels. This was attributed to direct and indirect effects of ω-3FA on the arterial wall.…”

Section: Discussionmentioning

confidence: 99%

<p>Evaluation of the Effect of Fish Oil Alone and in Combination with a Proprietary Chromium Complex on Endothelial Dysfunction, Systemic Inflammation and Lipid Profile in Type 2 Diabetes Mellitus – A Randomized, Double-Blind, Placebo-Controlled Clinical Study</p>

Pingali¹,

Nutalapati²,

Illendulla³

2020

DMSO

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This study was conducted to evaluate the effectiveness of fish oil alone and with an adjunct, a proprietary chromium complex (PCC), on cardiovascular parametersendothelial dysfunction, lipid profile, systemic inflammation and glycosylated hemoglobinin a 12-week randomized, double-blind, placebo-controlled clinical study in type 2 diabetes mellitus subjects. Patients and Methods: In this randomized, double-blind, parallel group study, 59 subjects in three groups completed the study: Group A, fish oil 2000 mg; Group B, fish oil 2000 mg + PCC 10 mg (200 µg of Cr 3+); and Group C, fish oil 2000 mg + PCC 20 mg (400 µg of Cr 3+) daily for 12 weeks (2000 mg of fish oil contained 600 mg of eicosapentaenoic acid [EPA] and 400 mg of docosahexaenoic acid [DHA], the omega-3 fatty acids). Endothelial function, by estimating reflection index (RI), biomarkers of oxidative stress (nitric oxide [NO], malondialdehyde [MDA], glutathione [GSH]) and inflammatory biomarkers (highsensitivity C-reactive protein [hsCRP], intercellular adhesion molecule-1 [ICAM-1], vascular cell adhesion molecule-1 [VCAM-1], endothelin-1) were evaluated at baseline, and 4 and 12 weeks. Lipid profile, platelet aggregation and glycosylated hemoglobin [HbA1c) were tested at baseline and 12 weeks. Any reported adverse drug reactions were recorded. Statistical analysis was performed using GraphPad Prism 8. Results: The present study shows that fish oil by itself, at a dose of 2000 mg (600 mg of EPA + 400 mg of DHA) per day, led to significant, but only modest, improvement in cardiovascular parameters (RI from −2.38±0.75 to −3.92±0.60, MDA from 3.77±0.16 to 3.74±0.16 nM/mL, NO from 30.60±3.18 to 32.12±3.40 µM/L, GSH from 568.93±5.91 to 583.95±6.53 µM/L; p≤0.0001), including triglyceride levels. However, when PCC was added to fish oil, especially at the 20 mg dose, there were highly significant improvements in all the parameters tested (RI from −2.04±0.79 to −8.73±1.36, MDA from 3.67±0.39 to 2.89±0.34 nM/mL, NO from 28.98±2.93 to 40.01±2.53 µM/L, GSH from 553.82±8.18 to 677.99±10.19 µM/L; p≤0.0001), including the lipid profile. It is noteworthy that the triglycerides were decreased significantly by addition of 20 mg of PCC although the dose of fish oil was only 2 g/day and the baseline triglyceride levels were only about 200 mg/dL. Fish oil alone did not significantly decrease the HbA1c, whereas the addition of 20 mg of PCC did. Conclusion: Addition of PCC, especially at 20 mg dose, significantly improves the efficacy of fish oil in addressing cardiovascular risk factors compared to fish oil given alone.

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Effects of omega-3 fatty acid plus alpha-tocopherol supplementation on malnutrition–inflammation score, biomarkers of inflammation and oxidative stress in chronic hemodialysis patients

Cited by 29 publications

References 32 publications

Update on the Impact of Omega 3 Fatty Acids on Inflammation, Insulin Resistance and Sarcopenia: A Review

Update on the Impact of Omega 3 Fatty Acids on Inflammation, Insulin Resistance and Sarcopenia: A Review

Factors Associated with Frailty and Its Trajectory among Patients on Hemodialysis

<p>Evaluation of the Effect of Fish Oil Alone and in Combination with a Proprietary Chromium Complex on Endothelial Dysfunction, Systemic Inflammation and Lipid Profile in Type 2 Diabetes Mellitus – A Randomized, Double-Blind, Placebo-Controlled Clinical Study</p>

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