Fiber-enriched biscuit enhances insulin secretion, modulates β-cell function, improves insulin sensitivity, and attenuates hyperlipidemia in diabetic rats

Erukainure, Ochuko L.; Ebuehi, Osaretin Albert Taiwo; Adeboyejo, Folasade Olabimpe; Okafor, E. N.; Muhammad, Aliyu; Elemo, Gloria N.

doi:10.1016/j.phanu.2013.02.001

Cited by 25 publications

(32 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Moreover, intake of SDF induced an increase in HDL-C while IDF led to a further decrease in the HDL-C concentration. The above results were partially consistent with those reported by Erukainure et al (2013), who found that fibre-enriched biscuit generated with mixtures of fibres obtained from oranges, pineapple, and watermelon inhibited the increase in TC, TG, and LDL-C induced by high glucose, insulin resistance and hepatic lipid metabolism and enhanced the HDL-C level. One possible explanation is that increased generation of SCFA during fermentation of DF in the colon inhibits cholesterol synthesis, leading to reduced levels of TC, TG, and LDL-C (Isken et al, 2010;Kaczmarczyk, Miller, & Freund, 2012;Kosmala, Kołodziejczyk, Zduń czyk, Juśkiewicz, & Boros, 2011).…”

Section: Effects Of Sdf and Idf On Liver Weight And Total Cholesterolsupporting

confidence: 92%

“…A previous study on the effects of low viscosity-HPMC (LV-HPMC) and HV-HPMC on insulin resistance in a ZDF rat model by Brockman et al (2012) disclosed higher QUICKI in the HV-HPMC group, suggestive of lower insulin resistance. Erukainure et al (2013) also…”

Section: Effects Of Sdf and Idf On Glucose Control Of Nondiabetic Andmentioning

confidence: 97%

“…Consumption of these foods may additionally decrease the dose requirement of drugs, consequently reducing undesirable sideeffects (Brockman, Chen, & Gallaher, 2012). Specific polysaccharides from fruits, vegetables and cereals can effectively regulate colon cancer, obesity, cardiovascular diseases and type 2 diabetes (Adam et al, 2014;Erukainure et al, 2013;Holt et al, 2009;Maxwell et al, 2016). Dietary fibre (DF), a category of natural polysaccharides, has been shown to decrease total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C) and triacylglycerol (TG) levels, alleviate insulin resistance, decrease postprandial blood glucose reaction, and inhibit inflammatory factors in obesity, type 2 diabetes and Zucker diabetic fatty (ZDF) rats (Galisteo et al, 2010;Toivonen et al, 2014;Weitkunat et al, 2015).…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Anti-diabetic effects of soluble and insoluble dietary fibre from deoiled cumin in low-dose streptozotocin and high glucose-fat diet-induced type 2 diabetic rats

2016

Journal of Functional Foods

View full text Add to dashboard Cite

Section: Effects Of Sdf and Idf On Liver Weight And Total Cholesterolsupporting

confidence: 92%

Section: Effects Of Sdf and Idf On Glucose Control Of Nondiabetic Andmentioning

confidence: 97%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Anti-diabetic effects of soluble and insoluble dietary fibre from deoiled cumin in low-dose streptozotocin and high glucose-fat diet-induced type 2 diabetic rats

2016

Journal of Functional Foods

View full text Add to dashboard Cite

“…This figure has been postulated to increase to 625 million by 2045, with Africa to account for 6.5% increase (IDF, 2018). It is a metabolic disease resulting from insulin deficiency (type 1 diabetes) and/or inability of the body to utilize secreted insulin (type 2 diabetes [T2D]), thus leading to increased blood glucose level (Erukainure et al, 2013;Vinayagam, Jayachandran, & Xu, 2016).…”

mentioning

confidence: 99%

Histochemistry, phenolic content, antioxidant, and anti-diabetic activities ofVernonia amygdalinaleaf extract

et al. 2018

Self Cite

View full text Add to dashboard Cite

Vernonia amygdalina leaves were investigated for their histochemical properties and antidiabetic activities. Histochemical analysis of the leaf revealed distributions of acidic lipid, mucilage, and pectin, lipids, polyphenols, and alkaloids at the mid rib, glandular trichome, and epidermis. HPLC analysis of the leaves hot water infusion revealed the presence of quercetin and (‐)‐epi‐catechin. The infusion had significant (p < 0.05) 2,2′‐diphenyl‐1‐picrylhydrazyl scavenging activity and ferric reducing antioxidant power. Ex vivo antioxidative analysis revealed the ability of the infusion to increase glutathione level, superoxide dismutase, and catalase activities, while concomitantly depleting malondialdehyde level and DNA fragmentation in Fe2+‐induced hepatic injury. The infusion showed significant (p < 0.05) inhibitory activity against α‐glucosidase and pancreatic lipase. It also inhibited intestinal glucose absorption and enhanced muscle glucose uptake, respectively. The ability of the infusion to abate oxidative stress, DNA fragmentation and stimulate muscle glucose uptake may suggest the antioxidative, anti‐apoptotic, and insulin‐sensitizing activity of V. amygdalina. Practical applications Vernonia amygdalina (bitter leaf) is among the common leafy vegetables in West Africa reported for its various medicinal and nutritional properties. It is utilized as a food ingredient as well as supplement for the treatment and management of type 2 diabetes (T2D). Its ability to inhibit intestinal glucose absorption, enhance muscle glucose uptake, and protect against hepatic oxidative stress gives more credence to its reported antidiabetic properties. Being a common leafy vegetable, V. amygdalina can be a cheap source of nutraceutical for the treatment and management of T2D and its complications.

show abstract

“…It is characterized by increased hyperglycemia resulting from defective production or action of insulin, leading to several complications such as cardiovascular, renal, neurological, and ocular disorders (Erukainure et al 2013). Growing evidence suggests that oxidative stress resulting from increased hyperglycemia plays a significant effect in the pathogenesis of DM and their complications (Brownlee 2001).…”

Section: Introductionmentioning

confidence: 99%

Methanolic extract of Celosia argentea var. crista leaves modulates glucose homeostasis and abates oxidative hepatic injury in diabetic rats

et al. 2018

View full text Add to dashboard Cite

Celosia argentea commonly known as cockscomb plant is widely used in folkloric medicine in the treatment and management of diabetes mellitus. The effect of methanolic extract of Celosia argentea var. cristata L. (CAVCL) leaves on blood glucose level, superoxide dismutase (SOD), catalase (CAT), alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP) activities, and malondialdehyde (MDA) level were evaluated in diabetic rats. Five groups of male albino rats consisting of 5 animals each were used for the present study. They were grouped as normal control, diabetic control, diabetic administered with 250 and 750 mg/kg b.w C. argentea, and 5 mg/kg b.w glibenclamide. Diabetes was induced with alloxan monohydrate intraperitoneally at 120 mg/kg b.w. The control and diabetic groups were given distilled water and rat chow for 21 days. Blood glucose level of each group was estimated every week, and at the end of the experiment, SOD, CAT, MDA and serum ALP, and AST and ALT activities were assayed in the liver and serum respectively of the experimental animals. The results showed a significant increase (p < 0.05) in serum AST, ALP, and ALT activities and reduction in SOD and CAT activities compared with normal control groups. The extract at both doses significantly lowered the high levels of the serum enzymes and increased the level of CAT and SOD. These results indicate an anti-hyperglycemia and antioxidative protective effect of C. argentea leaves.

show abstract

Fiber-enriched biscuit enhances insulin secretion, modulates β-cell function, improves insulin sensitivity, and attenuates hyperlipidemia in diabetic rats

Cited by 25 publications

References 29 publications

Anti-diabetic effects of soluble and insoluble dietary fibre from deoiled cumin in low-dose streptozotocin and high glucose-fat diet-induced type 2 diabetic rats

Anti-diabetic effects of soluble and insoluble dietary fibre from deoiled cumin in low-dose streptozotocin and high glucose-fat diet-induced type 2 diabetic rats

Histochemistry, phenolic content, antioxidant, and anti-diabetic activities ofVernonia amygdalinaleaf extract

Methanolic extract of Celosia argentea var. crista leaves modulates glucose homeostasis and abates oxidative hepatic injury in diabetic rats

Contact Info

Product

Resources

About