Fiber-based optical coherence tomography for biomedical imaging, sensing, and precision measurements

Lee, Byeong Ha; Min, Eun Jung; Kim, Young Ho

doi:10.1016/j.yofte.2013.07.011

Cited by 34 publications

(15 citation statements)

References 77 publications

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“…[8][9][10] It can provide "optical biopsy" in human tissue noninvasively and has been applied to imaging the retina, skin, gastrointestinal tract, and other accessible anatomical sites. 4,[11][12][13] Fiber-based OCT is compact and portable 14,15 and has been applied to colposcopic imaging previously. 3,6 Vincent et al 4 detected N-9-induced vaginal epithelial thinning and injury in human subjects from OCT B-scans, which could not otherwise be identified by conventional colposcopy.…”

Section: Introductionmentioning

confidence: 99%

Colposcopic imaging using visible-light optical coherence tomography

et al. 2017

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Abstract. High-resolution colposcopic optical coherence tomography (OCT) provides key anatomical measures, such as thickness and minor traumatic injury of vaginal epithelium, of the female reproductive tract noninvasively. This information can be helpful in both fundamental investigations in animal models and disease screenings in humans. We present a fiber-based visible-light OCT and two probe designs for colposcopic application. One probe conducts circular scanning using a DC motor, and the other probe is capable of three-dimensional imaging over a 4.6 × 4.6-mm 2 area using a pair of galvo scanners. Using this colposcopic vis-OCT with both probes, we acquired high-resolution images from whole isolated macaque vaginal samples and identified biopsy lesions.

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Section: Introductionmentioning

confidence: 99%

Colposcopic imaging using visible-light optical coherence tomography

et al. 2017

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“…Various probes have been developed for OCT to extend the range of its applications [4,5]. Compact, robust, and reliable endoscopic probes and imaging catheters have long been in demand in various fields of biomedical optics.…”

Section: Introductionmentioning

confidence: 99%

In Vivo Rat Brain Imaging through Full-Field Optical Coherence Microscopy Using an Ultrathin Short Multimode Fiber Probe

et al. 2019

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We demonstrate full-field optical coherence microscopy (OCM) using an ultrathin forward-imaging short multimode fiber (SMMF) probe with a core diameter of 50 μm, outer diameter of 125 μm, and length of 7.4 mm, which is a typical graded-index multimode fiber used for optical communications. The axial and lateral resolutions were measured to be 2.14 μm and 2.3 μm, respectively. By inserting the SMMF 4 mm into the cortex of an in vivo rat brain, scanning was performed to a depth of 147 μm from the SMMF facet with a field of view of 47 μm. Three-dimensional (3D) OCM images were obtained at depths ranging from approximately 20 μm to 90 μm. Based on the morphological information of the resliced 3D images and the dependence of the integration of the OCM image signal on the insertion length, the obtained 3D information of nerve fibers has been presented.

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“…Several reports on OCT endoscopes have been published in recent years [4]. A notable study of a forward-looking (imaging) intraocular OCT probe was conducted in 2013 [5].…”

Section: Introductionmentioning

confidence: 99%

Forward-looking OCT Probe Using Single-fiber Scanning for Transbronchial Puncturing Cytodiagnosis

Matsunaga

Suda

et al. 2017

ABE

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Bronchoscopic diagnosis of peripheral lung cancer with ground-glass opacity (GGO) is dif cult because GGO lesions cannot be visualized using currently available radial probe endobronchial ultrasound. Therefore, a forward-looking single ber scanning optical coherence tomography (OCT) probe with a local observation function has been developed to achieve precise sampling. The new OCT probe is only 1 mm in diameter. The probe is composed of a patterned electroplated copper coil fabricated on a polyimide tube using non-planar photofabrication technique, and an optical ber having a permanent magnetic tube with a diameter of 0.5 mm. When an electrical alternating current is supplied to the coil, the permanent magnet vibrates electromagnetically with the optical ber. To increase the ber vibration amplitude, a micro gradient-index (GRIN) lens is set in front of the tip of the optical ber. Using the micro GRIN lens, the output beam is focused, and the scanning range is enlarged. The view angle becomes approximately 45 , and image resolution becomes approximately 60 μm. The structure of grating was successfully imaged using the new OCT probe. Further improvements and animal experiments are necessary to determine the clinical application of the probe.

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Fiber-based optical coherence tomography for biomedical imaging, sensing, and precision measurements

Cited by 34 publications

References 77 publications

Colposcopic imaging using visible-light optical coherence tomography

Colposcopic imaging using visible-light optical coherence tomography

In Vivo Rat Brain Imaging through Full-Field Optical Coherence Microscopy Using an Ultrathin Short Multimode Fiber Probe

Forward-looking OCT Probe Using Single-fiber Scanning for Transbronchial Puncturing Cytodiagnosis

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