Fiber-based hybrid structures as scaffolds and implants for regenerative medicine

Brünler, Ronny; Hild, Martin; Aibibu, Dilbar; Cherif, Chokri

doi:10.1016/b978-0-08-100574-3.00012-6

Cited by 7 publications

(12 citation statements)

References 50 publications

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“…All this taken together indicates the formation of a heteroporous structure for PLA mats with added OTOA. As could be observed from Table 2, the introduction of OTOA affects the value of the open volume of the capillaries of the nonwoven fabric (V C ) and the proportion of the open volume of the capillaries to the total volume of the material (W C ), i.e., those characteristics that are largely responsible for the kinetic profile of controlled drug release [47]. The ultrathin fibers obtained in this work are mainly intended for use in various medical applications in the form of matrices and mats for the controlled release of biologically active substances [48], scaffolds in tissue engineering [49,50], artificial bioresorbable implants [51] and so on.…”

Section: Morphologymentioning

confidence: 99%

Effect of Glycero-(9,10-trioxolane)-trialeate on the Physicochemical Properties of Non-Woven Polylactic Acid Fiber Materials

et al. 2021

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Biocompatible glycero (9,10-trioxolane) trioleate (ozonide of oleic acid triglyceride, OTOA) was incorporated into polylactic acid (PLA) fibers by electrospinning and nonwoven PLA mats with 1%, 3% and 5% OTOA content. The morphological, mechanical, thermal and water sorption properties of electrospun PLA mats after the addition of OTOA were studied. A morphological analysis showed that the addition of OTOA increased the average fiber diameter and induced the formation of pores on the fiber surface, leading to an increase in the specific surface area for OTOA-modified PLA fibrous mats. PLA fiber mats with 3% OTOA content were characterized by a highly porous surface morphology, an increased specific surface area and high-water sorption. Differential scanning calorimetry (DSC) was used to analyze the thermal properties of the fibrous PLA mats. The glass transition temperatures of the fibers from the PLA–OTOA composites decreased as the OTOA content increased, which was attributed to the plasticizing effect of OTOA. DSC results showed that OTOA aided the PLA amorphization process, thus reducing the crystallinity of the obtained nonwoven PLA–OTOA materials. An analysis of the mechanical properties showed that the tensile strength of electrospun PLA mats was improved by the addition of OTOA. Additionally, fibrous PLA mats with 3% OTOA content showed increased elasticity compared to the pristine PLA material. The obtained porous PLA electrospun fibers with the optimal 3% OTOA content have the potential for various biomedical applications such as drug delivery and in tissue engineering.

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Section: Morphologymentioning

confidence: 99%

Effect of Glycero-(9,10-trioxolane)-trialeate on the Physicochemical Properties of Non-Woven Polylactic Acid Fiber Materials

et al. 2021

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“…This setup enables a user to vary the drawing ratio (defined as the ratio between the feed and winding speeds) by modifying the winding speed of the fibers. It also makes easier the change of feed material during a high-throughput screening with respect to traditional melt-spinning systems, as no single-screw or static mixers are required . Depending on the viscoelastic properties of the fed material, the feed speed of the precursor filament can be adjusted between 10 and 50 mm min –1 .…”

Section: Results and Discussionmentioning

confidence: 99%

“…48 This method is cost-effective, requires no additional solvents, and demonstrates high production rates. 49 However, the process is limited to using thermoplastic materials, with high energy consumption during heating, accurate temperature control, and regular equipment maintenance. 44 A different approach is needed to rapidly produce SMP fibers with controllable temperatures and dimensions at laboratory scale.…”

Section: ■ Introductionmentioning

confidence: 99%

“…It also makes easier the change of feed material during a high-throughput screening with respect to traditional melt-spinning systems, as no single-screw or static mixers are required. 49 Depending on the viscoelastic properties of the fed material, the feed speed of the precursor filament can be adjusted between 10 and 50 mm min −1 . The winding speed of the extruded fiber can be tuned from 1 to 4.6 m min −1 .…”

Section: ■ Introductionmentioning

confidence: 99%

“…In contrast, electrospinning uses an applied electric field to extrude nanofibers from a solution or melt onto a grounded collector. , While the process is better suited for benchtop fiber production, throughput of anisotropic fibers is low, and the volatile organic solvents and high electric fields used in electrospinning necessitate additional safety precautions. ,, Conventional melt-spinning is one of the most widespread fabrication methods for thermoplastics like nylon, polyethylene, polyester, cellulose triacetate, and PET . This method is cost-effective, requires no additional solvents, and demonstrates high production rates . However, the process is limited to using thermoplastic materials, with high energy consumption during heating, accurate temperature control, and regular equipment maintenance .…”

Section: Introductionmentioning

confidence: 99%

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All-Organic Electroactive Shape-Changing Knitted Textiles Using Thermoprogrammed Shape-Memory Fibers Spun by 3D Printing

Kim

Otal

Takizawa

et al. 2022

ACS Appl. Polym. Mater.

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Here, we present knittable shape-memory polymeric fibers extruded using a 3D-printer nozzle-based melt-spinning method for high throughput of composition and condition testing. These structures are used as the basis for electroactive shape-changing knitted textiles combining several types of fibers, including organic fibrous heaters. These structures represent a different approach to “on-demand” shape-memory fibers and can be incorporated into a variety of textile architectures, including inlaid knitting, diagonal interlacements, and a knit/purl design for an anisotropic knitted texture. The influence of manufacturing process parameters (e.g., drawing ratio during melt-spinning) on physical properties of the shape-memory fibers was measured using X-ray diffraction, thermomechanical cycling, scanning electron microscopy, and mechanical testing. The degree of crystallinity increased from 19.4 to 22.4% with the increased drawing ratio, with a maximum strain % of 450 and the fibers being able to lift 457 times their own weight. Further, we present a scalable strategy for bicomponent filament production, in which two distinct polymers are melt-spun in a side-by-side configuration and when actuated showed a coiled structure with different mechanical and thermal behavior than pure SMP fibers. The knitted textiles, obtained with a computer-controlled knitting machine able to produce 3D knitted structures, are deformed from two-dimensional planar structures to three-dimensional conformations by applying a voltage to the organic fibrous heaters. The deformed structure can be fixed by removing the applied voltage and can be returned to a planar configuration by heating and applying an uniaxial stress. Therefore, a hierarchical approach for fully textile-based, bendable, knittable, and electroactive soft actuators is presented. The results presented here demonstrate lab-scale production and high-throughput screening of advanced fibers with tunable properties.

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A Review: Textile Technologies for Single and Multi‐Layer Tubular Soft Tissue Engineering

Doersam

Tsigkou

Jones

2022

Adv Materials Technologies

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In addition, it requires a fundamental understanding of the structure and function of the target tissue type.Tubular tissues, such as vascular, respiratory, or intestinal systems supply the body with important nutrients and transport blood, air, food, or fluids. A defect in these tissues can considerably affect the patient's quality of life, for example, the required surgical reconstruction of connecting pathways between two anatomical structures can significantly reduce the patient's mobility. Current treatment strategies for diseased tubular tissues include transplantations of donor organs, autologous tissues, or implantable medical devices to restore tissue function. [2] However, transplants of donor organs or autologous tissue are limited due to availability, donor site morbidity, and risk of disease transmission. [3] Compared to natural body parts, implants have not yet reached the functionality, quality, or longevity (often need replacement after years). [3] Moreover, they must remain in the body for years, and material-specific compatibility problems can cause chronic inflammatory responses, thus limiting their clinical use. Being able to develop tissues outside the body provides a longterm alternative to organ transplantation that could offset the increasing discrepancy between the required number of donor organs needed and availability due to a growing and aging population and the higher life expectancy. [1] Additionally, eliminating the need for time-intensive therapy, for example, immune suppressants, and improving the patient quality of life. [1] Tubular tissues have many unifying structural and biomechanical characteristics despite their different functions. They consist of a multi-layered muscular wall structure of multiple different cell types. The different cell types are embedded in a surrounding environment, the extracellular matrix (ECM). [1] The ECM serves for the spatial organization of the cells and consists of fibrous structures, for example, collagen or elastin, which are proteins that form fiber bundles. [2] Fibrous structures can be found throughout the human body, whether in the architecture and ECM of specific tissue structures, such as arteries, lymphatic vessels, cartilage, or in the fibrous nature of nerves, muscles, ligaments, tendons. [4] A major aim of TE is to mimic the ECM and develop a 3D scaffold that will be seeded with native cells for tissue formation. Current scaffold designs of tubular tissues include foams, gel mattresses, sponges, meshes, and nanofibrous structures. [5] The scaffold serves as a template In cell-free scaffold tissue engineering (TE), an essential prerequisite is the scaffold design to promote cellular activities and tissue formation. The success is greatly dependent upon the nature of the scaffold including the composition, topography, and mechanical performance. Recent TE approaches use textile technologies to create biomimetic and functional scaffolds similar to the extracellular matrix (ECM). The hierarchical architecture of fiber to yarn to fabric a...

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Fiber-based hybrid structures as scaffolds and implants for regenerative medicine

Cited by 7 publications

References 50 publications

Effect of Glycero-(9,10-trioxolane)-trialeate on the Physicochemical Properties of Non-Woven Polylactic Acid Fiber Materials

Effect of Glycero-(9,10-trioxolane)-trialeate on the Physicochemical Properties of Non-Woven Polylactic Acid Fiber Materials

All-Organic Electroactive Shape-Changing Knitted Textiles Using Thermoprogrammed Shape-Memory Fibers Spun by 3D Printing

A Review: Textile Technologies for Single and Multi‐Layer Tubular Soft Tissue Engineering

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