Effect of Glycero-(9,10-trioxolane)-trialeate on the Physicochemical Properties of Non-Woven Polylactic Acid Fiber Materials

Olkhov, A. A.; Alexeeva, Olga V.; Konstantinova, M. L.; Podmaster’ev, V. V.; Tyubaeva, P. M.; Борунова, А. Б.; Siracusa, Valentina; Iordanskii, A. L.

doi:10.3390/polym13152517

Cited by 6 publications

(13 citation statements)

References 58 publications

(86 reference statements)

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“…To obtain film materials, NatureWorks ® Ingeo™ 3801X Injection Grade PLA (SONGHAN Plastics Technology Co., Ltd., Shanghai, China) with a viscosity-average molecular weight of 1.9 × 10 5 g/mol was used; PCL was used (SONGHAN Plastics Technology Co., Ltd., Shanghai, China) with a molecular weight of 90,000 ( Figure 1 ). Solutions were prepared using ≥99.5% dry purified chloroform (Sigma-Aldrich Inc., St. Louis, MO, USA); Glycero-(9,10-trioxolane)-trioleate (oleic acid triglyceride ozonide (OTOA)) was provided by Medozon (Moscow, Russia), and its chemical structure was described previously [ 17 , 18 ]. All reagents were used as received.…”

Section: Methodsmentioning

confidence: 99%

“…OTOA is non-toxic, biocompatible, has good biodegradability and antimicrobial activity. In recent studies [ 17 , 18 ], it has been already shown that the introduction of OTOA into PLA fibers and films led to improvement in the physicochemical properties of the material. We have now obtained novel film materials based on a PLA/PCL blend with the addition of various amounts of OTOA (0–40 wt %) as a modifier.…”

Section: Introductionmentioning

confidence: 99%

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A Novel Approach for Glycero-(9,10-trioxolane)-Trialeate Incorporation into Poly(lactic acid)/Poly(ɛ-caprolactone) Blends for Biomedicine and Packaging

Alexeeva,

Olkhov,

Konstantinova

et al. 2023

Polymers

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The product of ozonolysis, glycero-(9,10-trioxolane)-trioleate (ozonide of oleic acid triglyceride, [OTOA]), was incorporated into polylactic acid/polycaprolactone (PLA/PCL) blend films in the amount of 1, 5, 10, 20, 30 and 40% w/w. The morphological, mechanical, thermal and antibacterial properties of the biodegradable PLA/PCL films after the OTOA addition were studied. According to DSC and XRD data, the degree of crystallinity of the PLA/PCL + OTOA films showed a general decreasing trend with an increase in OTOA content. Thus, a significant decrease from 34.0% for the reference PLA/PCL film to 15.7% for the PLA/PCL + 40% OTOA film was established using DSC. Observed results could be explained by the plasticizing effect of OTOA. On the other hand, the PLA/PCL film with 20% OTOA does not follow this trend, showing an increase in crystallinity both via DSC (20.3%) and XRD (34.6%). OTOA molecules, acting as a plasticizer, reduce the entropic barrier for nuclei formation, leading to large number of PLA spherulites in the plasticized PLA/PCL matrix. In addition, OTOA molecules could decrease the local melt viscosity at the vicinity of the growing lamellae, leading to faster crystal growth. Morphological analysis showed that the structure of the films with an OTOA concentration above 20% drastically changed. Specifically, an interface between the PLA/PCL matrix and OTOA was formed, thereby forming a capsule with the embedded antibacterial agent. The moisture permeability of the resulting PLA/PCL + OTOA films decreased due to the formation of uniformly distributed hydrophobic amorphous zones that prevented water penetration. This architecture affects the tensile characteristics of the films: strength decreases to 5.6 MPa, elastic modulus E by 40%. The behavior of film elasticity is associated with the redistribution of amorphous regions in the matrix. Additionally, PLA/PCL + OTOA films with 20, 30 and 40% of OTOA showed good antibacterial properties on Pseudomonas aeruginosa, Raoultella terrigena (Klebsiella terrigena) and Agrobacterium tumefaciens, making the developed films potentially promising materials for wound-dressing applications.

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Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

A Novel Approach for Glycero-(9,10-trioxolane)-Trialeate Incorporation into Poly(lactic acid)/Poly(ɛ-caprolactone) Blends for Biomedicine and Packaging

Alexeeva,

Olkhov,

Konstantinova

et al. 2023

Polymers

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“…For example, when ozonizing vegetable oils, ozone reacts with unsaturated triacylglycerols contained in them (Figure 2) [28]. The oil ozonation product is a nontoxic, biocompatible, and biodegradable material, and is also a promising additive for introduction into the fibrillar matrix through electrospinning [29]. Combining the plasticizing properties of ozone-modified germicidal oils and the specificity of electroformed materials, it is possible to obtain a fundamentally new product with improved characteristics.…”

Section: Introductionmentioning

confidence: 99%

“…The authors [29] succeeded in introducing the oil ozonation product, glycerol (9,10-trioxolane) trioleate (ozonide of oleic acid triglyceride (OTOA)), into the electrospinning polymer matrix to obtain highly porous medical fibers. Fundamentally, new non-woven mats based on PLA with the addition of OTOA (1, 3, and 5 wt.…”

Section: Introduction Of Ozonated Oils Directly Into the Non-woven Fibermentioning

confidence: 99%

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Ozonation of Non-Woven Ultrathin Fibrous Biomaterials for Medical and Packaging Implementations

Alexeeva¹,

Siracusa²,

Konstantinova³

et al. 2022

Ozonation - New Aspects [Working Title]

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Antibiotic resistance of pathogens is among the major concerns in various medical applications. Therefore, the search for the novel antimicrobial agents that could prevent pathogen’s resistance, while maintaining efficient treatment, is one of the most important issues for biomedicine nowadays. One of the relevant methods for the development of functional non-woven materials possessing antimicrobial properties is the use of ozone and ozonolysis products for the modification of fibrous materials. This approach has recently attracted both academic and industrial interest and has found various biomedical applications. Several methods providing antimicrobial properties to textiles using ozone or ozonolysis products were proposed, including encapsulation and/or direct introduction of ozone-generated antimicrobial agents into the fibrous polymer matrix and ozone treatment of non-woven fiber materials. For the latter, the ozonolysis products are uniformly distributed predominantly on the polymer surface but could be also formed inside the polymer bulk due to ozone diffusion through the amorphous areas or defects. It was found that ozone modification of fibrous materials could lead to increase in hydrophilicity and improvement in their functional properties (smoothness, elasticity, strength, antimicrobial activity). In this chapter, various aspects of ozone modification of non-woven fiber materials for biomedical applications are reported and discussed.

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Electrospun biosensors for biomarker detection

Zhou,

Zheng,

Wang

et al. 2024

Colloid and Interface Science Communications

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Effect of Glycero-(9,10-trioxolane)-trialeate on the Physicochemical Properties of Non-Woven Polylactic Acid Fiber Materials

Cited by 6 publications

References 58 publications

A Novel Approach for Glycero-(9,10-trioxolane)-Trialeate Incorporation into Poly(lactic acid)/Poly(ɛ-caprolactone) Blends for Biomedicine and Packaging

A Novel Approach for Glycero-(9,10-trioxolane)-Trialeate Incorporation into Poly(lactic acid)/Poly(ɛ-caprolactone) Blends for Biomedicine and Packaging

Ozonation of Non-Woven Ultrathin Fibrous Biomaterials for Medical and Packaging Implementations

Electrospun biosensors for biomarker detection

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