Fiber average size and distribution dependence on the electrospinning parameters of poly(vinylidene fluoride–trifluoroethylene) membranes for biomedical applications

Abstract

Poly(vinylidene fluoride-trifluoethylene), P(VDF-TrFE), electrospun membranes were obtained from a mixture of dimethylformamide (DMF) and methylethylketone (MEK) solvents. The inclusion of MEK to the solvent system promotes a faster solvent evaporation allowing complete polymer crystallization during the jet travelling between the tip and the grounded collector.The main electrospinning processing parameters were systematically changed to study their influence on fiber dimensions and distribution. Applied voltage and inner needle diameter do not have large influence on the electrospun fiber average diameter but in the fiber diameter distribution. On the other hand, increasing the distance between the needle tip and the collector gives origin to fibers with larger average diameter. Independently on the processing conditions, all mats are produced in the electroactive phase of the polymer. Further, MC-3T3-E1cell adhesion is not inhibited by the fiber mats preparation, showing their potential use for biomedical applications.

Thermal and hydrolytic degradation of electrospun fish gelatin membranes

“…Furthermore, the cross-linked fibers showed the same appearance as the as-spun ones (Figure 1b). Similar behavior has been reported for other polymers such as chitosan [29].…”

Energy harvesting performance of piezoelectric electrospun polymer fibers and polymer/ceramic composites

“…The influence of the electrospun processing parameters on average fiber size and characteristics such as electroactive phase content and degree of crystallinity of PVDF [27] and P(VDF-TrFE) [28] have been study previously, and this section will focus on the composite fibers. The influence of the applied electric field in the BaTiO3/P(VDFTrFE) electrospun fibers nanocomposites has been evaluated keeping constant the needle inner diameter of 0.5 mm and the flow rate of 0.5 mL/h.…”

Crystalline polymorphism in poly(vinylidenefluoride) membranes

“…Page 61 of 96 A c c e p t e d M a n u s c r i p t 61 Membranes based on PVDF and its copolymers (such as P(VDF-TrFE)) show large potential for use in biomaterials, tissue engineering, and artificial blood vessels [162] especially for bone repair, and nerve guidance reconstruction [163] because of its piezoelectric properties and proven biocompatibility including good blood compatibility. PVDF membranes containing the piezoelectric β phase can be prepared, and have potential as a suitable scaffold for above mentioned biomedical applications.…”