FGL2/Fibroleukin mediates hepatic reperfusion injury by induction of sinusoidal endothelial cell and hepatocyte apoptosis in mice

Selzner, Nazia; Líu, Hao; Boehnert, Markus; Adeyi, Oyedele; Shalev, Idan; Bartczak, Agata; Xuezhong, Max; Manuel, José; Rotstein, Ori D.; McGilvray, Ian; Grant, David; Phillips, M. J.; Levy, Gary; Selzner, Markus

doi:10.1016/j.jhep.2011.05.033

Cited by 45 publications

(29 citation statements)

References 44 publications

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“…In the gene-array experiments using PC-3 clones, FGF-2 was significantly downregulated by fgl-2 silencing, and this process was associated with a decrease in activation/phosphorylation of ERK1/2. These findings are in accordance with the previously well-established role of the FGF pathway in angiogenesis, wound healing, and carcinogenesis [22,29,30]. Specifically, FGF binding to its receptor, FGFR, leads to FGFR autophosphorylation and activation [31], ultimately followed by signal transduction through multiple downstream pathways, including the ERK/MAP kinases [24].…”

Section: Discussionsupporting

confidence: 90%

The cell-membrane prothrombinase, fibrinogen-like protein 2, promotes angiogenesis and tumor development

Rabizadeh

Cherny

Lederfein

et al. 2015

Thrombosis Research

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Section: Discussionsupporting

confidence: 90%

The cell-membrane prothrombinase, fibrinogen-like protein 2, promotes angiogenesis and tumor development

Rabizadeh

Cherny

Lederfein

et al. 2015

Thrombosis Research

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“…53 Inhibition of fibroleukin has shown beneficial effects in a model of hepatic reperfusion, decreasing liver injury by lowering the apoptotic levels of mice hepatocytes and sinusoidal endothelial cells. 54 In addition to the procoagulatory role of regions outside the FBG domain, the FBG domain of fibroleukin has shown some immune-suppressive effects. It can abolish LPS-induced maturation of bone marrow-derived dendritic cells, resulting in inhibition of T cell proliferation, and this phenomenon could be rescued by adding antibodies against the FBG domain of fibroleukin.…”

Section: Patterns [Damps]mentioning

confidence: 99%

Fibrinogen-Related Proteins in Tissue Repair: How a Unique Domain with a Common Structure Controls Diverse Aspects of Wound Healing

Zuliani-Alvarez

Midwood

2015

Advances in Wound Care

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Fibrinogen-related proteins (FRePs) comprise an intriguing collection of extracellular molecules, each containing a conserved fibrinogen-like globe (FBG). This group includes the eponymous fibrinogen as well as the tenascin, angiopoietin, and ficolin families. Many of these proteins are upregulated during tissue repair and exhibit diverse roles during wound healing. An increasing body of evidence highlights the specific expression of a number of FRePs following tissue injury and infection. Upon induction, each FReP uses its FBG domain to mediate quite distinct effects that contribute to different stages of tissue repair, such as driving coagulation, pathogen detection, inflammation, angiogenesis, and tissue remodeling. Despite a high degree of homology among FRePs, each contains unique sequences that enable their diversification of function. Comparative analysis of the structure and function of FRePs and precise mapping of regions that interact with a variety of ligands has started to reveal the underlying molecular mechanisms by which these proteins play very different roles using their common domain. Fibrinogen has long been used in the clinic as a synthetic matrix serving as a scaffold or a delivery system to aid tissue repair. Novel therapeutic strategies are now emerging that harness the use of other FRePs to improve wound healing outcomes. As we learn more about the underlying mechanisms by which each FReP contributes to the repair response, specific blockade, or indeed potentiation, of their function offers real potential to enable regulation of distinct processes during pathological wound healing.

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“…In histology and pathology, immunohistochemistry is one of the most useful methods in paraffin technique staining, such as H&E staining and TUNEL staining [27]. Apoptosis is generally considered as a physiological programmed cell death, it is essentially different with necrosis.…”

Section: Discussionmentioning

confidence: 99%

Radioprotective activity of neutral polysaccharides isolated from the fruiting bodies of Hohenbuehelia serotina

Wang

2015

Physica Medica

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FGL2/Fibroleukin mediates hepatic reperfusion injury by induction of sinusoidal endothelial cell and hepatocyte apoptosis in mice

Cited by 45 publications

References 44 publications

The cell-membrane prothrombinase, fibrinogen-like protein 2, promotes angiogenesis and tumor development

The cell-membrane prothrombinase, fibrinogen-like protein 2, promotes angiogenesis and tumor development

Fibrinogen-Related Proteins in Tissue Repair: How a Unique Domain with a Common Structure Controls Diverse Aspects of Wound Healing

Radioprotective activity of neutral polysaccharides isolated from the fruiting bodies of Hohenbuehelia serotina

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