FGF-7 (keratinocyte growth factor) expression during mouse development suggests roles in myogenesis, forebrain regionalisation and epithelial-mesenchymal interactions

Mason, Ivor; Fuller-Pace, Frances V.; Smith, Rosalind; Dickson, Clive

doi:10.1016/0925-4773(94)90050-7

Cited by 264 publications

(157 citation statements)

References 65 publications

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“…We found skeletal muscle (this report; Orr-Urtreger et al, 1993; that KGF and KGFR gene expression are generally Mason et al, 1994) adds yet another FGF family memassociated with the mesenchyme and epithelium, re-ber to the list of factors which may regulate muscle spectively. These results further confirm the patterns development.…”

Section: Discussionsupporting

confidence: 58%

“…These results further confirm the patterns development. KGF transcripts have been detected in of KGF and KGFR expression observed in cell lines, somites, the dermomyotome, and the individual differand the responsiveness of epithelial cells to KGF in entiating muscles (this report; Mason et al, 1994). vitro Finch et al, 1989).…”

Section: Discussionmentioning

confidence: 77%

“…However, expression in organs of the abdominal cavity, which given the overlapping binding specificity of many FGF were not reported by the previous studies. Further-receptors as well as the overlapping expression of FGF more, the studies by Mason et al (1994) and Orr-family members during muscle development, the role Urtreger et al (1993) examined expression of KGF or of KGF and other FGFs in myogenesis remains to be KGFR in the absence of the corresponding receptor or clarified. In this regard, the KGFR can bind FGF-1 ligand expression.…”

Section: Discussionmentioning

confidence: 99%

“…Mesenchymal cells from the somite (possibly also neural crest cells) ventral to the dorsal root ganglion also expressed KGF message, while the neural tube and dorsal root ganglion were negative. KGF message was expressed in the mesen- (male) aComparative analysis of the anatomical sites of KGF expression detected by in situ hybridization with those described by Mason et al (1994). Cart.…”

Section: Kgf Kgfrmentioning

confidence: 99%

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Pattern of keratinocyte growth factor and keratinocyte growth factor receptor expression during mouse fetal development suggests a role in mediating morphogenetic mesenchymal‐epithelial interactions

Finch

Cunha

Rubin

et al. 1995

Developmental Dynamics

265

171

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Mesenchymal cells are required for the induction of epithelial development during mammalian organogenesis. Keratinocyte growth factor (KGF) is a mesenchymally derived mitogen with specific activity for epithelial cells, suggesting that it may play a role in mediating these interactions. To further evaluate this hypothesis, in situ hybridization was used to examine the spatial distribution of KGF and KGF receptor (KGFR) transcripts during organogenesis and limb formation in mouse embryos (days 14.5 through 16.5). To facilitate this aim, mouse KGF cDNA clones were isolated. There was extensive identity between the deduced mouse KGF protein sequence and that of its human and rat cognates, indicating that this gene has been highly conserved during mammalian evolution. In addition, mouse KGF protein was purified from fibroblasts and demonstrated to be structurally and functionally similar to human KGF protein. For organs within the integumental, respiratory, gastrointestinal, and urogenital systems, whose development is dependent upon mesenchymal‐epithelial interactions, KGF mRNA was detected in mesenchymal cells, while epithelial cells expressed transcripts for the KGFR. KGF and KGFR mRNA was also expressed in certain other tissues such as perichondrium, cartilage of developing bones, developing skeletal muscle, and visceral smooth muscle whose development is not regulated by mesenchymal‐epithelial interactions. KGF expression was also detected in tissues isolated from human embryos, suggesting similar functions for KGF in human development. Taken together, our results suggest that KGF plays an important role in mediating mesenchymal‐epithelial interactions during organogenesis, but may also have other developmental functions in tissues not governed by such interactions. ©1995 Wiley‐Liss, Inc.

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Section: Discussionsupporting

confidence: 58%

Section: Discussionmentioning

confidence: 77%

Section: Discussionmentioning

confidence: 99%

Section: Kgf Kgfrmentioning

confidence: 99%

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Pattern of keratinocyte growth factor and keratinocyte growth factor receptor expression during mouse fetal development suggests a role in mediating morphogenetic mesenchymal‐epithelial interactions

Finch

Cunha

Rubin

et al. 1995

Developmental Dynamics

265

171

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“…Of interest, we have also observed a novel domain of Fgf3 expression in the lateral telencephalon between E11.5 and E12.5. Thereafter Fgf3 expression has also been described in the basal ganglia at E14.5, where also Fgf7 has been detected (Mason et al, 1994;Yaylaoglu et al, 2005).…”

Section: Discussionmentioning

confidence: 83%

Differential requirements for Fgf3 and Fgf8 during mouse forebrain development

Theil

Domínguez-Frutos

Schimmang

2008

Developmental Dynamics

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Effects of keratinocyte growth factor (KGF) on gut growth and repair

et al. 1998

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Keratinocyte growth factor (KGF) is a mitogen found throughout the gastrointestinal tract, but its role in gastrointestinal pathophysiology is unclear. The effect of recombinant KGF on gut growth and repair has been examined using a variety of in vivo models. Rats receiving total parenteral nutrition had co‐infusions of KGF or control for 6 days. Changes in gut growth (wet weight and vincristine‐induced metaphase arrest) were then assessed. The effects of KGF on gastric repair and acid secretion in rats were determined using an indomethacin (20 mg/kg)/restraint model and animals fitted with chronic gastric fistulae. KGF at 0·1, 1, and 3 mg/kg increased gut growth as assessed by wet weight throughout the gastrointestinal tract and increased vincristine‐induced accumulation of metaphases in the stomach and small intestine but not in the colon. Plasma gastrin, peptide YY, enteroglucagon, and glucagon‐like peptide‐1 were all increased, whereas insulin was lowered by KGF (all P<0·01). KGF was ineffective in reducing indomethacin‐induced gastric damage but caused a reduction in basal acid secretion of about 35 and 50 per cent when administered at 0·2 or 5 mg/kg (P<0·05). These studies support the idea that KGF is involved in the control of proliferation of the gastrointestinal tract. They do not provide evidence, however, for a role in the early reparative process invoked during short‐term models of gastrointestinal injury. © 1998 John Wiley & Sons, Ltd.

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FGF-7 (keratinocyte growth factor) expression during mouse development suggests roles in myogenesis, forebrain regionalisation and epithelial-mesenchymal interactions

Cited by 264 publications

References 65 publications

Pattern of keratinocyte growth factor and keratinocyte growth factor receptor expression during mouse fetal development suggests a role in mediating morphogenetic mesenchymal‐epithelial interactions

Pattern of keratinocyte growth factor and keratinocyte growth factor receptor expression during mouse fetal development suggests a role in mediating morphogenetic mesenchymal‐epithelial interactions

Differential requirements for Fgf3 and Fgf8 during mouse forebrain development

Effects of keratinocyte growth factor (KGF) on gut growth and repair

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