Differential requirements for Fgf3 and Fgf8 during mouse forebrain development

Theil, Thomas; Domínguez-Frutos, Elena; Schimmang, Thomas

doi:10.1002/dvdy.21765

Cited by 17 publications

(16 citation statements)

References 44 publications

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“…Early embryonic expression of FGF-8 and FGF-17 in the midbrain-hindbrain boundary has been shown to be important for correct patterning of the brain and proper development of the midbrain [8], [35]–[37]. In early mouse embryos FGF-3 expression has been detected in the midbrain and the lateral ganglionic eminence (precursor of the striatum) of the telencephalon, [38], [39]. However, the impact of FGF-3 and FGF-16 expression in postnatal striatum on maturation or maintenance of DA neurons has to our knowledge not been studied.…”

Section: Discussionmentioning

confidence: 99%

FGF-2 Deficiency Does Not Influence FGF Ligand and Receptor Expression during Development of the Nigrostriatal System

2011

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Secreted proteins of the fibroblast growth factor (FGF) family play important roles during development of various organ systems. A detailed knowledge of their temporal and spatial expression profiles, especially of closely related FGF family members, are essential to further identification of specific functions in distinct tissues. In the central nervous system dopaminergic neurons of the substantia nigra and their axonal projections into the striatum progressively degenerate in Parkinson's disease. In contrast, FGF-2 deficient mice display increased numbers of dopaminergic neurons. In this study, we determined the expression profiles of all 22 FGF-ligands and 10 FGF-receptor isoforms, in order to clarify, if FGF-2 deficiency leads to compensatory up-regulation of other FGFs in the nigrostriatal system. Three tissues, ventral mesencephalon (VM), striatum (STR) and as reference tissue spinal cord (SC) of wild-type and FGF-2 deficient mice at four developmental stages E14.5, P0, P28, and adult were comparatively analyzed by quantitative RT-PCR. As no differences between the genotypes were observed, a compensatory up-regulation can be excluded. Moreover, this analysis revealed that the majority of FGF-ligands (18/22) and FGF-receptors (9/10) are expressed during normal development of the nigrostriatal system and identified dynamic changes for some family members. By comparing relative expression level changes to SC reference tissue, general alterations in all 3 tissues, such as increased expression of FGF-1, -2, -22, FgfR-2c, -3c and decreased expression of FGF-13 during postnatal development were identified. Further, specific changes affecting only one tissue, such as increased FGF-16 (STR) or decreased FGF-17 (VM) expression, or two tissues, such as decreased expression of FGF-8 (VM, STR) and FGF-15 (SC, VM) were found. Moreover, 3 developmentally down-regulated FGFs (FGF-8b, FGF-15, FGF-17a) were functionally characterized by plasmid-based over-expression in dissociated E11.5 VM cell cultures, however, such a continuous exposure had no influence on the yield of dopaminergic neurons in vitro.

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Section: Discussionmentioning

confidence: 99%

FGF-2 Deficiency Does Not Influence FGF Ligand and Receptor Expression during Development of the Nigrostriatal System

2011

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“…For instance, the depletion of FGF8 leads to a severe rostral hypoplasia resulting from the reduction of progenitor proliferation and survival . This phenotype is worsen by the inactivation of FGF3 in the FGF8 KO mouse line . Other ligands such has FGF2, FGF8 and FGF15 show opposite functions, with FGF15 promoting progenitor differentiation while FGF8 and FGF2 favouring their self‐renewal .…”

Section: Regulation Of the Biology Of Cortical Progenitors By Csf‐dermentioning

confidence: 99%

Cerebral cortex development: an outside‐in perspective

2017

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The cerebral cortex is a complex structure that contains different classes of neurons distributed within six layers and regionally organized into highly specialized areas. Cortical layering arises during embryonic development in an inside-out manner as forebrain progenitors proliferate and generate distinct waves of interneurons and projection neurons. Radial glial cells (RGCs) derive from neuroepithelial cells and are the founding cortical progenitors. At the onset of corticogenesis, RGCs expand their pool by proliferative divisions. As corticogenesis proceeds, they gradually undergo differentiative divisions to either generate neurons directly (direct neurogenesis) or indirectly via production of intermediate progenitors that further divide to generate pairs of neurons (indirect neurogenesis). The fate of RGCs is finely regulated during all the corticogenesis process and depends on time-scaled perception of external signals and expression of intrinsic factors. The present Review focuses on the role of physiological extracellular cues arising from the vicinity of neural progenitors on the regulation of dorsal neurogenesis and cerebral cortex patterning. It further discusses how pathogenic viral factors influence RGC behaviour and disrupt cerebral cortex development.

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“…In all vertebrates examined, FGFs are expressed within both fpderived cells of the ventral hypothalamic midline (Manning et al, 2006) and the forming infundibulum (Tannahill et al, 1992;Ohuchi et al, 2000;Herzog et al, 2004;Theil et al, 2008;Tsai et al, 2011), where they may play multiple roles in the neuroendocrine hypothalamus. FGFs act as spatial and proliferative cues for progenitors within Rathke's pouch, which is the precursor of the anterior pituitary (Ericson et al, 1998;Norlin et al, 2000;Zhu et al, 2007), and additionally promote diverse aspects of specification of neuroendocrine neurons (Tsai et al, 2011).…”

Section: Introductionmentioning

confidence: 99%

FGF-dependent midline-derived progenitor cells in hypothalamic infundibular development

et al. 2011

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SUMMARYThe infundibulum links the nervous and endocrine systems, serving as a crucial integrating centre for body homeostasis. Here we describe that the chick infundibulum derives from two subsets of anterior ventral midline cells. One set remains at the ventral midline and forms the posterior-ventral infundibulum. A second set migrates laterally, forming a collar around the midline. We show that collar cells are composed of Fgf3 + SOX3 + proliferating progenitors, the induction of which is SHH dependent, but the maintenance of which requires FGF signalling. Collar cells proliferate late into embryogenesis, can generate neurospheres that passage extensively, and differentiate to distinct fates, including hypothalamic neuronal fates and Fgf10 + anterior-dorsal infundibular cells. Together, our study shows that a subset of anterior floor plate-like cells gives rise to Fgf3 + SOX3 + progenitor cells, demonstrates a dual origin of infundibular cells and reveals a crucial role for FGF signalling in governing extended infundibular growth.

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Differential requirements for Fgf3 and Fgf8 during mouse forebrain development

Cited by 17 publications

References 44 publications

FGF-2 Deficiency Does Not Influence FGF Ligand and Receptor Expression during Development of the Nigrostriatal System

FGF-2 Deficiency Does Not Influence FGF Ligand and Receptor Expression during Development of the Nigrostriatal System

Cerebral cortex development: an outside‐in perspective

FGF-dependent midline-derived progenitor cells in hypothalamic infundibular development

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