Fexinidazole and Human African Trypanosomiasis: good news for this important neglected tropical disease

Bayão, Taciana de Souza; Cupertino, Marli do Carmo; Gomes, Andréia Patrícia; Siqueira-Batista, Rodrigo

doi:10.1590/0037-8682-0176-2019

Cited by 1 publication

(2 citation statements)

References 11 publications

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“…During this period, some countries underwent economic crises, civil wars and deterioration of their healthcare systems, especially in Angola and the Democratic Republic of Congo. The support of the World Health Organization (WHO), national control programs, bilateral cooperation, and the action of non-governmental organizations were necessary to control this last epidemic (Bayão et al, 2019;WHO, 2013).…”

Section: Etiology and Epidemiologymentioning

confidence: 99%

“…Human African trypanosomiasis (HAT) or sleeping sickness is a Neglected Tropical Disease (NTD) seriously impacting populations with greater social, cultural, and economic vulnerabilities (Bayão et al, 2019). The disease is caused by subspecies of the protozoa Trypanosoma brucei (highlighting Trypanosoma brucei gambiense, most prevalent in Central and Western Africa -and Trypanosoma brucei rhodesiense, prevalent in East Africa), transmitted by the tsetse fly of the genus Glossina (Scarim et al, 2019;Siqueira-Batista et al, 2020).…”

Section: Introductionmentioning

confidence: 99%

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Human african trypanosomiasis: current standing and challenges

et al. 2020

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Human African trypanosomiasis (HAT) caused by the protozoan Trypanosoma brucei gambiense and Trypanosoma brucei rhodesiense, and transmitted by the tsetse fly (genus Glossina), affects 36 Sub-Saharan African countries with considerable public health impact. Despite approximately 15,000 infected individuals and 70 million at risk, in recent years the World Health Organization has mentioned removal of HAT from the list of Neglected Tropical Diseases by 2020, due to the decrease in cases over the last two decades. When untreated, the disease presents high lethality rates and the available treatments are complicated to administer, highly toxic, and do not guarantee cure, especially in the advanced stages of the disease. Further, there is no prospect for vaccine development in the near future. The present review compiles information on the history of the clinical aspects of HAT, as well as its epidemiology, diagnosis, therapy, and prophylaxis, as well as updating information on the current panorama and perspectives regarding the disease.KEY WORDS: African Trypanosomiasis; neglected diseases; Trypanosoma brucei.

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Section: Etiology and Epidemiologymentioning

confidence: 99%