Fever Therapy

Solomon, Harry C.; Kopp, Israel

doi:10.1056/nejm193711182172101

Cited by 18 publications

(9 citation statements)

References 2 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Before the advent of antibiotics, "fever therapy" was regarded as a useful treatment of some infectious diseases [38]. It can be postulated that the regulatory effects of fever-like conditions on maturing DCs may account for this beneficial effect.…”

Section: Discussionmentioning

confidence: 99%

Fever-like thermal conditions regulate the activation of maturing dendritic cells

Tournier

Hellmann

Lesca

et al. 2003

Journal of Leukocyte Biology

View full text Add to dashboard Cite

Fever is one of the most frequent clinical signs encountered in pathology, especially with respect to infectious diseases. It is currently thought that the role of fever on immunity is limited to activation of innate immunity; however, its relevance to activation of adaptive immunity remains unclear. Dendritic cells (DCs) that behave as sentinels of the immune system provide an important bridge between innate and adaptive immunity. To highlight the role of fever on adaptive immunity, we exposed murine bone marrow-derived lipopolysaccharide (LPS)- or live bacteria-maturing DCs over a 3-h period to 37 degrees C or to fever-like thermal conditions (39 degrees C or 40 degrees C). At these three temperatures, we measured the kinetics of cytokine production and the ability of DCs to induce an allogeneic mixed lymphocyte reaction. Our results show that short exposure of DCs to temperatures of 39 degrees C or 40 degrees C differentially increased the secretion of interleukin (IL)-12p70 and decreased the secretion of IL-10 and tumor necrosis factor alpha by maturing DCs. These fever-like conditions induced a regulation of cytokine production at the single-cell level. In addition, short-term exposed LPS-maturing DCs to 39 degrees C induced a stronger reaction with allogeneic CD4(+) T cells than maturing DCs incubated at 37 degrees C. These results provide evidence that temperature regulates cytokine secretion and DC functions, both of which are of particular importance in bacterial diseases.

show abstract

Section: Discussionmentioning

confidence: 99%

Fever-like thermal conditions regulate the activation of maturing dendritic cells

Tournier

Hellmann

Lesca

et al. 2003

Journal of Leukocyte Biology

View full text Add to dashboard Cite

show abstract

“…Animal models44 of bacterial sepsis indicate fever to be an adaptive host immunological defence associated with improved survival. And in humans, the cure of syphilis by inducing fever with malaria won Dr Wagner von Jauregg the 1927 Nobel Prize for medicine!45…”

Section: Is Csa–csr a Compensatory Mechanism For Severe Hf?mentioning

confidence: 99%

Cheyne–Stokes respiration: friend or foe?: Figure 1

Naughton

2012

Thorax

174

View full text Add to dashboard Cite

“…The low tolerance of spirochetes for high temperatures is well known and may explain in part the restricted distribution of B. burgdorferi to temperate latitudes and its absence in the tropics, where infected ticks may be exposed to high temperatures detrimental to spirochete survival. Interestingly, the thermal sensitivity of T. pallidum was exploited in the early 1900s prior to the discovery of penicillin by using fever therapy with malaria or relapsing fever infection to treat patients with general paresis (31).…”

Section: Phenotypic Response To Changes In Temperaturementioning

confidence: 99%