2001
DOI: 10.1172/jci12484
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Borrelia burgdorferi and Treponema pallidum: a comparison of functional genomics, environmental adaptations, and pathogenic mechanisms

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Cited by 50 publications
(39 citation statements)
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“…B burgdorferi does not produce true LPS, and genomic analysis has shown that LPS biosynthetic genes are absent (28). The recombinant proteins used in the current study contained LPS in quantities comprising 0.1-1.0% of total protein, presumably arising as a contaminant during production and purification.…”
Section: Discussionmentioning
confidence: 95%
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“…B burgdorferi does not produce true LPS, and genomic analysis has shown that LPS biosynthetic genes are absent (28). The recombinant proteins used in the current study contained LPS in quantities comprising 0.1-1.0% of total protein, presumably arising as a contaminant during production and purification.…”
Section: Discussionmentioning
confidence: 95%
“…This finding excludes more rapid elimination of OspB as an explanation for its failure to induce injury. It is also unlikely that differences in NF-B activation are involved, because all lipidated OSPs (OspA, OspB, and OspC) were able to activate this major inflammatory pathway in selected target cell populations, whereas the nonlipidated versions were not effective (6,27) (28). Expression of OSP gene products in the tick vector and the mammalian host has been studied previously (30).…”
Section: Discussionmentioning
confidence: 99%
“…Immunization of hosts against OspA protects against tick-borne infection by killing OspA-expressing spirochetes in the tick midgut during the initial stages of feeding (22). When spirochetes are transmitted to naïve hosts, they do not express OspA (24,30,40) and are therefore no longer vulnerable to OspA immunity (15). These dynamics are reflected in the sera of most patients and animals following tick-borne infection with B. burgdorferi.…”
mentioning
confidence: 99%
“…Upon transmission, the spirochetes stay in the skin at the attachment site for several days and then disseminate throughout the vertebrate host (42). Early in infection, spirochetes express OspC but not OspA (11,30,37). In addition to these two lipoproteins that seem to be involved in adaptation to different environments, there is mounting evidence that genes encoding different antigens are differentially expressed or repressed in response to a variety of environmental cues during pathogen-tick-host interactions (7,8,13,22,26,27,32,38,39,41,44,45).…”
mentioning
confidence: 99%