Fever-range whole-body heat treatment stimulates antigen-specific T-cell responses in humans

Kobayashi, Yuki; Ito, Yusuke; Ostapenko, Valentina V.; Sakai, Mayuko; Matsushita, Norimasa; Imai, Kenichiro; Shimizu, Koïchi; Aruga, Atsushi; Tanigawa, Keishi

doi:10.1016/j.imlet.2014.09.014

Cited by 19 publications

(21 citation statements)

References 27 publications

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“…However, these differences did not influence test performance, as there was no significant difference in positive, negative and indeterminate results associated with incubation temperature. The findings are in contrast to the literature [22,23] and our previous proof-of-concept study [19]. One study explored the impact of hypothermic (35°C) incubation on QFT performance and found little impact [28], suggesting that the QFT performs consistently over a wide range of incubation temperatures (35°C-39°C).…”

Section: Discussioncontrasting

confidence: 93%

“…Fever is an essential component of normal immune function in-vivo and the immunomodulatory effects of fever and febrile-range temperatures have been well categorized and include effects on cytokine expression, antigen presentation, and lymphocyte proliferation [20][21][22][23][24]. In a whole blood model we showed that IFN-γ and IP-10 release was significantly increased at 39°C compared to 37°C incubation temperature in response to M. tuberculosis specific antigens and to mitogens in patients with TB.…”

Section: Introductionmentioning

confidence: 99%

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Thermostability of IFN-γ and IP-10 release assays for latent infection with Mycobacterium tuberculosis: A TBnet study

et al. 2016

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Section: Discussioncontrasting

confidence: 93%

Section: Introductionmentioning

confidence: 99%

Thermostability of IFN-γ and IP-10 release assays for latent infection with Mycobacterium tuberculosis: A TBnet study

et al. 2016

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“…Statistical differences from control was evaluated using paired t-test. P < 0.05 was recognized statistically significant [42] . IFN: interferon; IL: interleukin; PBMCs: peripheral blood mononuclear cells NK cells is exercised at this time to complement T-cellbased immune reactions owing to attenuated inhibitory signals between NK cells and cancer cells [61] .…”

Section: Hyperthermia Enhances Immune Systems In Response To Cancermentioning

confidence: 90%

“…Statistical differences from the control were evaluated using paired t-test. P < 0.05 was recognized as statistically significant [42] . IFN: interferon; IL: interleukin; PBMCs: peripheral blood mononuclear cells treatment.…”

Section: Hyperthermia Enhances Immune Systems In Response To Cancermentioning

confidence: 99%

Cancer immunity and therapy using hyperthermia with immunotherapy, radiotherapy, chemotherapy, and surgery

Yagawa¹,

Tanigawa²,

Kobayashi³

et al. 2017

JCMT

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Hyperthermia is a type of medical modality for cancer treatment using the biological effect of artificially induced heat. Even though the intrinsic effects of elevated body temperature in cancer tissues are poorly understood, increasing the temperature of the body has been recognized as a popular therapeutic method for tumorous lesions as well as infectious diseases since ancient times. Recently accumulated evidence has shown that hyperthermia amplifies immune responses in the body against cancer while decreasing the immune suppression and immune escape of cancer. It also shows that hyperthermia inhibits the repair of damaged cancer cells after chemotherapy or radiotherapy. These perceptions indicate that hyperthermia has potential for cancer therapy in conjunction with immunotherapy, chemotherapy, radiotherapy, and surgery. Paradoxically, the anticancer effect of hyperthermia alone has not yet been adequately exploited because deep heating techniques and devices to aggregate heat effects only in cancer tissues are difficult in practical terms. This review article focuses on the current understanding concerning cancer immunity and involvement of hyperthermia and the innate and adoptive immune system. The potential for combination therapy with hyperthermia and chemotherapy, radiotherapy, and surgery is also discussed. Key words:Hyperthermia, cancer immunity, chemosensitizer, radiosensitizer, combination cancer therapy, hyperthermic intraoperative peritoneal chemotherapy ABSTRACTArticle history:

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“…Febrile temperatures also enhance functions of dendritic cells, and their enhanced antigen-presenting function increases stimulation of T-cells [70,[79][80][81]. It is thought that the heat-mediated increase in membrane fluidity has effects on organising the response of the adaptive immune system, promoting activation of T-cells in areas where the temperature is increased [82][83][84].…”

Section: The Immune System and Hyperthermiamentioning

confidence: 99%

Improving efficacy of hyperthermia in oncology by exploiting biological mechanisms

Tempel¹,

Horsman

Kanaar³

2016

International Journal of Hyperthermia

101

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It has long been established that hyperthermia increases the therapeutic benefit of radiation and chemotherapy in cancer treatment. During the last few years there have been substantial technical improvements in the sources used to apply and measure heat, which greatly increases enthusiasm for the clinical use of hyperthermia. These advances are converging with a better understanding of the physiological and molecular effects of hyperthermia. Therefore, we are now at a juncture where the parameters that will influence the efficacy of hyperthermia in cancer treatment can be optimised in a more systematic and rational manner. In addition, the novel insights in hyperthermia's many biological effects on tumour cells will ultimately result in new treatment regimes. For example, the molecular effects of hyperthermia on the essential cellular process of DNA repair suggest novel combination therapies, with DNA damage response targeting drugs that should now be clinically explored. Here, we provide an overview of recent studies on the various macroscopic and microscopic biological effects of hyperthermia. We indicate the significance of these effects on current treatments and suggest how they will help design novel future treatments. ARTICLE HISTORY

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Fever-range whole-body heat treatment stimulates antigen-specific T-cell responses in humans

Cited by 19 publications

References 27 publications

Thermostability of IFN-γ and IP-10 release assays for latent infection with Mycobacterium tuberculosis: A TBnet study

Thermostability of IFN-γ and IP-10 release assays for latent infection with Mycobacterium tuberculosis: A TBnet study

Cancer immunity and therapy using hyperthermia with immunotherapy, radiotherapy, chemotherapy, and surgery

Improving efficacy of hyperthermia in oncology by exploiting biological mechanisms

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