Thermostability of IFN-γ and IP-10 release assays for latent infection with Mycobacterium tuberculosis: A TBnet study

Blauenfeldt, Thomas; Wagner, Dirk; Aabye, Martine G.; Heyckendorf, Jan; Lange, Berit; Lange, Christoph; Ernst, Martin; Ravn, Pernille; Duarte, Raquel; Morais, Clara; Hoffmann, Matthias; Schoch, Otto D.; Domínguez, José; Latorre, Irene; Rühwald, Morten

doi:10.1016/j.tube.2015.04.013

Cited by 9 publications

(9 citation statements)

References 39 publications

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“…The main characteristics of the 18 articles, comprising 24 trials, are listed in Tables 1 and 2 [7, 13–29]. In total, 2836 participants were involved.…”

Section: Resultsmentioning

confidence: 99%

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Accumulate evidence for IP-10 in diagnosing pulmonary tuberculosis

Qiu

Xiong

et al. 2019

BMC Infect Dis

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BackgroundsPulmonary tuberculosis (PTB) is a major health and economic burden. Accurate PTB detection is an important step to eliminating TB globally. Interferon gamma-induced protein 10 (IP-10) has been reported as a potential diagnostic marker for PTB since 2007. In this study, a meta-analysis approach was used to assess diagnostic value of IP-10 for PTB.MethodsWeb of Science, PubMed, the Cochrane Library, and Embase databases were searched for studies published in English up to February 2019. The pooled sensitivity, specificity, positive likelihood ratio (PLR), negative likelihood ratio (NLR), diagnostic odds ratio (DOR), the area under the curve (AUC) and hierarchical summary receiver operating characteristic (HSROC) curve were estimated by the HSROC model and random effect model.ResultsEighteen studies including 2836 total participants met our inclusion criteria. The pooled sensitivity, specificity, PLR, and NLR of IP-10 for PTB detection were 86, 88%, 7.00, and 0.16, respectively. The pooled DOR was 43.01, indicating a very powerful discriminatory ability of IP-10. The AUC was 0.93 (95% CI: 0.91–0.95), showed the accuracy of IP-10 was good. Meta-regression showed that there was no heterogeneity with respect to TB burden, study design type, age, IP-10 assay method, IP-10 condition and HIV-infection status.ConclusionsOur results showed that IP-10 is a promising marker for differentiating PTB from non-TB.

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“…The main characteristics of the 18 articles, comprising 24 trials, are listed in Tables 1 and 2 [7, 13–29]. In total, 2836 participants were involved.…”

Section: Resultsmentioning

confidence: 99%

“…Age and gender do not affect the level of IP-10 [11, 12]. Since 2007, IP-10 has been reported as a potential parameter for PTB detection [7, 13–29].…”

Section: Introductionmentioning

confidence: 99%

Accumulate evidence for IP-10 in diagnosing pulmonary tuberculosis

Qiu

Xiong

et al. 2019

BMC Infect Dis

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“…The search for new markers for the auxiliary diagnosis of PTB is ongoing. Several studies have shown that IP-10 is a promising marker for PTB detection [7] [13][14][15][16][17][18][19][20][21][22][23][24][25][26][27][28][29].…”

Section: Discussionmentioning

confidence: 99%

Accumulate evidence for IP-10 in diagnosing pulmonary tuberculosis

Qiu

Xiong

et al. 2019

Preprint

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Backgrounds: Pulmonary tuberculosis (PTB) is a major health and economic burden. Accurate PTB detection is an important step to eliminating TB globally. I nterferon gamma-induced protein 10 (IP-10) has been reported as a potential diagnostic marker for PTB since 2007. In this study, a meta-analysis approach was used to assess diagnostic value of IP-10 for PTB. Methods: Web of Science, PubMed, the Cochrane Library, and Embase databases were searched for studies published in English up to February 2019. The pooled sensitivity, specificity, positive likelihood ratio (PLR), negative likelihood ratio (NLR), diagnostic odds ratio (DOR), the area under the curve (AUC) and hierarchical summary receiver operating characteristic (HSROC) curve were estimated by the HSROC model and random effect model. Results: Eighteen studies including 2836 total participants met our inclusion criteria. The pooled sensitivity, specificity, PLR, and NLR of IP-10 for PTB detection were 86%, 88%, 7.00, and 0.16, respectively. The pooled DOR was 43.01, indicating a very powerful discriminatory ability of IP-10. The AUC was 0.93 (95% CI: 0.91–0.95), showed the accuracy of IP-10 was good. Meta-regression showed that there was no heterogeneity with respect to TB burden, study design type, age, IP-10 assay method, IP-10 condition and HIV-infection status. Conclusions: Our results showed that IP-10 is a promising marker for differentiating PTB from non-TB.

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“…An aspect that has not been broadly experimentally addressed is the potential implications of fever on the interaction with the host with environment and the development of the infection. 6 Therefore, this study will focus on fever as an important variable to be considered in infectious diseases research, focusing especially on seasonal variation of fever cases attendance at a tertiary care centre in rural area of Himachal Pradesh.…”

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confidence: 99%

Seasonal Trend of Fever Cases Seeking Health Care Services at a Tertiary Care Centre- An Audit of Retrospective Data From Sub-Himalayan Region

Sharma¹,

Singh²,

Gandhi³

et al. 2018

jemds

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BACKGROUND Climate change is expected to alter the geographic and seasonal distributions of existing vectors and vector-borne diseases. Febrile illness is the most common presentation of these diseases and a public health problem affecting most of the people in developing world along with the prevailing burden of other communicable diseases. Aims and Objectives-To study the seasonal trend analysis (2013-15) of fever cases admitted in a tertiary centre of Himachal Pradesh. MATERIALS AND METHODS A retrospective descriptive record-based analysis of fever cases admitted in medicine and paediatrics ward from 2013-15 of Dr. Rajendra Prasad Government Medical College, Kangra at Tanda, H.P. RESULTS Among febrile illnesses, fever of unknown origin is the leading cause of illness in all the three years. There is a resurgence of scrub typhus infection with increasing trend of cases in monsoon and post-monsoon season. Fever with neurological involvement was also recorded among young and productive age group in winter season with an upward trend. CONCLUSION There are only a limited number of studies from India reporting on the aetiology of fever and reliable surveillance data are not available; hence, a better insight in the epidemiology of febrile diseases will be helpful in order to target clinical work-up and treatment.

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Thermostability of IFN-γ and IP-10 release assays for latent infection with Mycobacterium tuberculosis: A TBnet study

Abstract: The performance of IGRA and IP-10 release assays is robust despite variations in the incubation temperature between 37 °C and 39 °C.

Cited by 9 publications

References 39 publications

Accumulate evidence for IP-10 in diagnosing pulmonary tuberculosis

Accumulate evidence for IP-10 in diagnosing pulmonary tuberculosis

Accumulate evidence for IP-10 in diagnosing pulmonary tuberculosis

Seasonal Trend of Fever Cases Seeking Health Care Services at a Tertiary Care Centre- An Audit of Retrospective Data From Sub-Himalayan Region

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