Fever in children: from symptom to diagnosis

Захарова, И. Н.; Заплатников, А Л; Творогова, Т. М.; Холодова, И. Н.

doi:10.21518/2079-701x-2017-1-212-218

Cited by 4 publications

(1 citation statement)

References 3 publications

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“…Оба препарата имеют длительный опыт клинического применения. Фармакодинамика, фармакологическое действие, схемы применения, а также нежелательные реакции и органы-мишени изучены и описаны как для ПАР 2 [2][3][4][5][6][7][8][9][10], так и для ИБУ 3 [11][12][13][14][15][16].…”

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Safety Pharmacology Study of Medicines Used for Febrile Syndrome Management in Children

Kryshen¹,

Мошков²,

Демяновский³

et al. 2020

Bezopasnost' i risk farmakoterapii

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Summary. Safety pharmacology studies of paediatric medicines are an important stage in the life cycle of drugs.The purpose of the study was to analyse and compare the safety pharmacology profiles of the recommended paediatric dosage regimens of a fixed ibuprofen (IBU)/paracetamol (PAR) combination and of IBU and PAR monopreparations following repeated oral administration of these products to juvenile rats. Material and methods: safety pharmacology was assessed in both male and female outbred juvenile rats. Two dose levels were used in the study—the highest treatment dose (HTD) equivalent for juvenile rats, and the three-times-equivalent therapeutic dose (3 HTD). The animals were given the fixed IBU/PAR combination in the form of suspension from dispersible tablets (100 mg IBU + 120 mg PAR), IBU in the form of oral suspension (100 mg/5 mL), and PAR in the form of oral suspension (120 mg/5 mL). Statistical processing was performed using Statistica 10.0 software. Results: unlike monopreparations, the fixed IBU/PAR combination did not have clinically significant hepatotoxic or nephrotoxic effects when administered to juvenile rats. Administration of IBU alone resulted in an increase in blood urea nitrogen concentration in female rats (HTD) and male rats (3 HTD), and a small amount of leucocytes in the urine of female rats. Administration of PAR resulted in an increase in the amount of red blood cells in the urine of male rats. Administration of the monopreparations at the HTD dose led to a decrease in the locomotor activity of the animals. No significant effect on the cardiovascular or respiratory systems was observed for any of the products.Conclusions: the safety pharmacology profile of the fixed IBU/PAR combination after repeated oral administration to juvenile rats did not differ much from those of IBU and PAR used alone, and in some cases was even better.

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Safety Pharmacology Study of Medicines Used for Febrile Syndrome Management in Children

Kryshen¹,

Мошков²,

Демяновский³

et al. 2020

Bezopasnost' i risk farmakoterapii

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Treatment of fever in acute upper respiratory tract infections in children

et al. 2022

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Introduction. The WHO recommends using acetaminophen (paracetamol) and ibuprofen in fever treatment in children and does not recommend their use in sequence to avoid overdose. However, in recent years, preparations containing both medicinal components have appeared, which allows fever to be relieved safely and the daily dosage of the medicines to be reduced.Objective. To obtain additional data on the efficacy and safety of antipyretic drug combination in comparison with mono drugs in children with the febrile syndrome in acute upper respiratory tract infectionsMaterials and methods. Single-center non-interventional (observational) comparative study was conducted in children from 3 to 12 years of age with acute respiratory infections accompanied by fever. Children were divided into 3 groups: the treatment group (83 children) received a combined antipyretic drug in the form of dispensable tablets (100 mg ibuprofen and 125 mg paracetamol); control group 1 (42 children) received paracetamol in the form of suspension; control group 2 (43 children) received ibuprofen in the form of suspension. The clinical efficacy and safety of antipyretic therapy and also the satisfaction of the patients’ parents, were evaluated in the dynamics.Results. The results showed similar efficacy and safety of all three medications, but the daily dose of medications with the combined dispersible tablets was lower, more so for paracetamol and somewhat less so for ibuprofen. In the combined dispersible tablets group, the proportion of patients with a temperature < 37.2 °C was statistically significantly higher 1 hour after administration than in the paracetamol and ibuprofen drug groups. Ibuprofen only compared with the study drug in terms of efficacy after 2 hours, while paracetamol was already effective after 3 hours.Conclusions. The study showed that the combined drug in the form of dispersible tablets (100 mg of ibuprofen and 125 mg of paracetamol) showed statistically significant efficacy parameters, is safe and well-tolerated by patients.

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Features of diagnosis and therapy of febrile syndrome in young children

Kholodova,

Tvorogova,

Kholodov

et al. 2023

Medicinskij sovet

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In this article, the authors raise the issue of the treatment of febrile conditions in young children. At the same time, the emphasis is on the definition of feverish conditions, etiopathogenesis, and the possibilities of modern diagnostics, taking into account various types of constitution in children. The authors provide their own data, based on many years of experience in monitoring children of the main three constitutional types according to M.S. Maslov. The features of fever therapy in children, indications and contraindications to the appointment of antipyretic drugs are discussed, emphasis is placed on side effects and contraindications of these drugs for infants. In recent years, the attention of many doctors has been drawn to the theory and practice of bioregulatory medicine, which is a branch of modern medicine that uses the experience of using natural remedies. The data of Russian and international researchers proving the expediency and effectiveness of treating fever symptoms with these drugs are presented. Special attention is paid to the drug Viburcol, which can be used for children starting from birth, which is undoubtedly important, since it is for children of the first year of life that safe and effective means are needed due to increased sensitivity to the toxic effects of all medicines. It is shown that the use of Viburcol suppositories in children is advisable, allows you to achieve the desired effect without any toxic and side effects. The authors, referring to international and Russian experience, recommend Viburcol for the treatment of fever, excitability, anxiety, pathological teething, as well as in the preparation and management of children during vaccination.

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Fever in children: from symptom to diagnosis

Cited by 4 publications

References 3 publications

Safety Pharmacology Study of Medicines Used for Febrile Syndrome Management in Children

Safety Pharmacology Study of Medicines Used for Febrile Syndrome Management in Children

Treatment of fever in acute upper respiratory tract infections in children

Features of diagnosis and therapy of febrile syndrome in young children

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