FEV1 is associated with risk of asthma attacks in a pediatric population

Fuhlbrigge, Anne L.; Kitch, Barrett T.; Paltiel, A. David; Kuntz, Karen M.; Neumann, Peter J.; Dockery, Douglas W.; Weiss, Scott T.

doi:10.1067/mai.2001.111590

Cited by 259 publications

(169 citation statements)

References 39 publications

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“…Pre-FEV 1 has been validated as a measure of airway obstruction as it closely correlates with pathologic scores of airway diameter (Hogg et al 1968). Decreased measures of pre-FEV 1 were shown to be associated with the risk of future attacks and response to therapy among children with asthma (Enright et al 1994;Fuhlbrigge et al 2001). A previous study in Latino Americans showed that asthma severity might be influenced by ancestry in Mexican Americans .…”

Section: Discussionmentioning

confidence: 99%

Admixture-matched case-control study: a practical approach for genetic association studies in admixed populations

et al. 2005

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Case-control genetic association studies in admixed populations are known to be susceptible to genetic confounding due to population stratification. The transmission/disequilibrium test (TDT) approach can avoid this problem. However, the TDT is expensive and impractical for late-onset diseases. Case-control study designs, in which cases and controls are matched by admixture, can be an appealing and suitable alternative for genetic association studies in admixed populations. In this study, we applied this matching strategy when recruiting our African American participants in the Study of African American, Asthma, Genes and Environments (SAGE). Group admixture in this cohort consists of 83% African ancestry and 17% European ancestry, which was consistent with reports from other studies. By carrying out several complementary analyses, our results show that there is substructure in the cohort, but that the admixture distributions are almost identical in cases and controls, and also in cases only. We performed association tests for asthma-related traits with ancestry, and only found that FEV 1 , a measure for baseline pulmonary function, was associated with ancestry after adjusting for socio-economic and environmental risk factors (P = 0.01). We did not observe an excess of type I error rate in our association tests for ancestry informative markers (AIMs) and asthma-related phenotypes when ancestry was not adjusted in the analyses. Furthermore, using the association tests between genetic variants in a known asthma candidate gene, β 2 adrenergic receptor (β 2 AR) and ΔFEF 25-75 , an asthma-related phenotype, as an † Correspondence and reprint requests should be addressed to:

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Section: Discussionmentioning

confidence: 99%

Admixture-matched case-control study: a practical approach for genetic association studies in admixed populations

et al. 2005

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“…bations include having severe and persistent airfl ow obstruction based on spirometry and any history of intubation or admission to the ICU. [15][16][17][18][19] The strongest predictor for risk of exacerbations is a history of previous exacerbation. 8,16 The objectives of this study were (1) to assess the association of asthma symptoms with severe asthma exacerbations, and (2) to compare predictors of persistent asthma symptoms and predictors of severe exacerbations in children with asthma.…”

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Predictors of Symptoms Are Different From Predictors of Severe Exacerbations From Asthma in Children

Tantisira

et al. 2011

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“…21 Se recomienda el monitoreo del FEV 1 < 60 %, ya que en un estudio retrospectivo de cohorte se identificó el declive de FEV 1 como responsable de las crisis (FEV 1 < 60 %, razón de momio [RM] = 2.1 e intervalo de confianza de 95 % [IC 95 %] = 1.3-3, comparado con FEV 1 < 80 %, RM = 1.4 e IC 95 % = 1-2-1.6). 22 Más recientemente estos hallazgos fueron confirmados por Osborne et al 23 Los mismos investigadores sugirieron identificar la exposición al cigarro y la sensibilidad positiva al perro o gato, pues estos factores se asociaron con mayor riesgo para ser hospitalizado. 23 La obesidad debe ser considerada un factor de riesgo, pues en un estudio retrospectivo, la obesidad grados I a III fue asociada con empeoramiento de la gravedad del asma (RM = 4.23, IC 95 % = 1.61-11.06, p = 0.003; obesidad grados II y III, RM = 2.76, IC 95 % = 1.08-7.09, p = 0.03).…”

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“…Désirée Larenas-Linnemann, 1 Jorge Salas-Hernández, 2 Juan Carlos Vázquez-García, 3 Ignacio Ortiz-Aldana, 4 Margarita Fernández-Vega, 5 Blanca Estela Del Río-Navarro, 6 María del Carmen Cano-Salas, 7 Jorge Agustín Luna-Pech, 8 José Antonio Ortega-Martell, 9 Jade Romero-Lombard, 10 Erika del Carmen López-Estrada, 11 Jimena Villaverde-Rosas, 12 José Luis Mayorga-Butrón, 13 Mario Humberto Vargas-Becerra, 14 Martín BedollaBarajas, 15 Noel Rodríguez-Pérez, 16 Ambrocio Aguilar-Aranda, 17 Carlos Adrián Jiménez-González, 18 Carlos García-Bolaños, 19 Claudia GarridoGalindo, 20 David Alejandro Mendoza-Hernández, 21 Enrique Mendoza-López, 22 Gerardo López-Pérez, 21 Guillermo Hideo Wakida-Kuzonoki, 23 Héctor Hernán Ruiz-Gutiérrez, 24 Héctor León-Molina, 25 Héctor Martínez-De la Lanza, 26 Héctor Stone-Aguilar, 27 Javier Gómez-Vera, 28 Jorge…”

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Guía Mexicana del Asma: GUIMA 2017

Larenas-Linnemann¹,

Salas-Hernández²,

Vázquez-García³

et al. 2017

RAM

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Este artículo debe citarse como: Larenas-Linnemann D, Salas-Hernández J, Vázquez-García JC, Ortiz-Aldana I, Fernández-Vega M, Del Río-Navarro BE, et al. Guía Mexicana del Asma 2017. Rev Alerg Mex. 2017;64 Supl 1:s11-s128. AbstractBackground: The need for a national guideline, with a broad basis among specialists and primary care physicians was felt in Mexico, to try unifying asthma management. As several high-quality asthma guidelines exist worldwide, it was decided to select the best three for transculturation. Methods: Following the internationally recommended methodology for guideline transculturation, ADAPTE, a literature search for asthma guidelines, published 1-1-2007 through 31-12-2015 was conducted. AGREE-II evaluations yielded 3/40 most suitable for transculturation. Their compound evidence was fused with local reality, patient preference, cost and safety considerations to draft the guideline document. Subsequently, this was adjusted by physicians from 12 national medical societies in several rounds of a Delphi process and 3 face-to-face meetings to reach the final version. Results: Evidence was fused from British Thoracic Society Asthma Guideline 2014, Global Initiative on Asthma 2015, and Guía Española del Manejo del Asma 2015 (2016 updates included). After 3 Delphi-rounds we developed an evidence-based document taking into account patient characteristics, including age, treatment costs and safety and best locally available medication. Conclusion: In cooperation pulmonologists, allergists, ENT physicians, paediatricians and GPs were able to develop an evidence-based document for the prevention, diagnosis and treatment of asthma and its exacerbations in Mexico.Keywords: Clinical practice guideline; Asthma; Asthmatic exacerbation; Bronchodilator; Inhaled corticosteroid; Spirometry; Immunotherapy. IntroducciónLa presentación de este documento muestra la importancia del asma en México por su alta prevalencia, pero también por su subdiagnóstico y tratamiento deficiente, que propician un mal control de los pacientes con asma, crisis más frecuentes y sintomatología activa. En consecuencia, el asma tiene un impacto socioeconómico considerable para el paciente y la sociedad en su conjunto, al igual que afecta la calidad de vida del paciente y su familia. En México, el paciente con asma puede recibir atención médica en los ámbitos pú-blico o privado, en los diferentes niveles de salud y por múltiples especialidades. Todas estas particularidades de la situación nacional indican la necesidad de un documento guía actualizado, con base amplia en múltiples gremios médicos, tanto de primer nivel de atención como de especialidad.El objetivo de la GUIMA 2017 es facilitar la reducción de la morbimortalidad por asma en México, no solo al mejorar el conocimiento acerca de esta patología, sino también al ayudar a la parte administrativa del Sector Salud a gestionar la selección y adquisición más precisa de los medicamentos necesarios para su tratamiento a nivel de la salud pública. Para tal fin se ofrecen lineamientos par...

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FEV1 is associated with risk of asthma attacks in a pediatric population

Cited by 259 publications

References 39 publications

Admixture-matched case-control study: a practical approach for genetic association studies in admixed populations

Admixture-matched case-control study: a practical approach for genetic association studies in admixed populations

Predictors of Symptoms Are Different From Predictors of Severe Exacerbations From Asthma in Children

Guía Mexicana del Asma: GUIMA 2017

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