Fetus-in-fetu: A rare congenital anomaly

Gupta, Saurabh Kumar; Singhal, Parul; Arya, Neera

doi:10.4103/2006-8808.73621

Cited by 8 publications

(9 citation statements)

References 12 publications

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“…FIF is a condition, commonly occurs in retroperitoneal space (80%) 2. Others rare sites like sacrococcygeal region, intracranial, thorax, pelvis, scrotum, back and oral cavity have also been described in the literature 3–5.…”

Section: Discussionmentioning

confidence: 99%

Fetus in fetu in an adult woman

Kumar¹,

Paswan

Kumar

et al. 2019

BMJ Case Rep

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Fetus in fetu (FIF) is an extremely rare condition in which malformed fetus is found most commonly in the retroperitoneum of living twin. It occurs in about 1 in 500 000 live births and less than 200 cases have been reported in medical literature. We report FIF in a 17-year-old woman unlike other cases which were usually detected in early age and in male gender. This is the eighth case of adult FIF and the first case of FIF in adult woman worldwide. Preoperative diagnosis of FIF on CT was made and planned for exploratory laparotomy. The excised malformed fetus in a sac was proven as FIF on the basis of histopathological examination. In view to avoid such late presentation, early detection of FIF with radiological imaging in clinically suspected case is recommended. Surgical excision is the ideal treatment even teratoma is the differential diagnosis.

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Section: Discussionmentioning

confidence: 99%

Fetus in fetu in an adult woman

Kumar¹,

Paswan

Kumar

et al. 2019

BMJ Case Rep

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“…DNA and chromosomal analysis indicates that the host and the defective fetus are genetically identical. The classical fusion theory, based on the pattern of the anomalies but not on embryological models of their pathogenesis, proposes that these pathologies result from the secondary union of two monozygotic embryonic discs [104]–[108]. In spite that the pathogenic mechanisms remain theoretical and are unclear, it is remarkable that the brain is always vestigial or missing in the defective twin fetus, which joins the normal twin at either ventral or dorsal locations [109].…”

Section: Discussionmentioning

confidence: 99%

An Intact Brachyury Function Is Necessary to Prevent Spurious Axial Development in Xenopus laevis

et al. 2013

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We have previously shown that the member of the HES family hairy2 induces the ectopic expression of dorsal markers when it is overexpressed in the ventral side of Xenopus embryos. Intriguingly, hairy2 represses the mesoderm transcription factor brachyury (bra) throughout its domain in the marginal zone. Here we show that in early gastrula, bra and hairy2 are expressed in complementary domains. Overexpression of bra repressed hairy2. Interference of bra function with a dominant-negative construct expanded the hairy2 domain and, like hairy2 overexpression, promoted ectopic expression of dorsal axial markers in the ventral side and induced secondary axes without head and notochord. Hairy2 depletion rescued the ectopic dorsal development induced by interference of bra function. We concluded that an intact bra function is necessary to exclude hairy2 expression from the non-organiser field, to impede the ectopic specification of dorsal axial fates and the appearance of incomplete secondary axes. This evidence supports a previously unrecognised role for bra in maintaining the dorsal fates inhibited in the ventral marginal zone, preventing the appearance of trunk duplications.

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“…This extremely rare phenomenon (overall clinical prevalence is 1:500,000 live births, with fewer than 100 cases reported worldwide) is believed to be connected with unequal division of parasitic blastocyst totipotent cells (Gangopadhyay et al, 2010;Klaus and Ericksen, 2013). It is usually a benign condition, more frequently found in infants and children (about 90% of cases are identified before 18 months of age) (Karaman et al, 2008;Gupta et al, 2010;Mohta and Khurana, 2011), although there have been reports of cases in adults (Massad et al, 2001). Symptoms occur due to the parasitic twin compressing the surrounding organs of its host (Reddy et al, 2012).…”

Section: Discussionmentioning

confidence: 99%

Ovarian teratoma: A case from 15th–18th century Lisbon, Portugal

Wasterlain

Alves

Garcia

et al. 2017

International Journal of Paleopathology

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This paper discusses the differential diagnosis of an unusual calcified mass found in the pelvic cavity of 45+-year-old female excavated from 15th-18th century Lisbon (Portugal). The mass is relatively large, irregularly shaped, and exhibits a concave base with malformed teeth embedded within its inner surface. Considering its macroscopic and radiological characteristics, several conditions were considered in the differential diagnosis, namely eccyesis, fetus in fetu, lithopaedion, and ovarian teratoma. However, the morphological features of the specimen, such as its structure, morphology, and dimensions, are diagnostic of a teratoma. Its location and the sex of the individual are more specifically compatible with a calcified ovarian teratoma. With regional and temporal variations in the frequency of tumours, the report of new cases becomes imperative, especially from geographic regions where few cases have been identified. In fact, this appears to be the first case of ovarian teratoma detected in the Portuguese archaeological record and adds to the few palaeopathological cases described in the osteoarchaeological literature worldwide.

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Fetus-in-fetu: A rare congenital anomaly

Cited by 8 publications

References 12 publications

Fetus in fetu in an adult woman

Fetus in fetu in an adult woman

An Intact Brachyury Function Is Necessary to Prevent Spurious Axial Development in Xenopus laevis

Ovarian teratoma: A case from 15th–18th century Lisbon, Portugal

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